Anti-inflammatory activity of macrolides: a new therapeutic potential?
J Antimicrob Chemother
; 41 Suppl B: 37-46, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9579711
The important role played by macrolides in the chemotherapy of infectious diseases is well established, but there is still much speculation about their anti-inflammatory potential. A review of in-vitro and ex-vivo studies reported in the literature shows that macrolides have potentially relevant immunomodulatory effects. In-vitro data suggest that erythromycin A derivatives have a direct effect on neutrophil function and the production of cytokines involved in the inflammation cascade. The ex-vivo results indicate that short-term administration of macrolides may enhance the immune response while long-term administration results in immunosuppression. Further research is required to improve our understanding of the therapeutic activity of macrolides.
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Base de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Antiinflamatorios
/
Antibacterianos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia