Neonatal mouse immunity against group B streptococcal infection by maternal vaccination with recombinant anti-idiotypes.
Nat Med
; 4(6): 705-9, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9623980
ABSTRACT
We investigated whether immunization with recombinant anti-idiotypic antibody fragments mimicking the conformation of the capsular antigen can protect against infection by group B streptococcus, an important neonatal pathogen. Single-chain fragment-variable anti-idiotypes competed with the type III carbohydrate for binding to type-specific antibodies and elicited, in mice, the production of protective immunoglobulins reacting against the type III polysaccharide. Moreover, maternal immunization with soluble or phage-displayed fragments protected neonatal mice against streptococcal infection. These data indicate that recombinant anti-idiotypic antibodies may be useful in developing protein images of relevant carbohydrate epitopes and, ultimately, in preventing infections by encapsulated bacteria.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Infecciones Estreptocócicas
/
Streptococcus agalactiae
/
Anticuerpos Antiidiotipos
/
Vacunas de ADN
/
Inmunidad Materno-Adquirida
Límite:
Animals
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia