Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade.
Science
; 280(5372): 2121-6, 1998 Jun 26.
Article
en En
| MEDLINE
| ID: mdl-9641919
ABSTRACT
Hippocampal pyramidal cells are called place cells because each cell tends to fire only when the animal is in a particular part of the environment-the cell's firing field. Acute pharmacological blockade of N-methyl-D-aspartate (NMDA) glutamate receptors was used to investigate how NMDA-based synaptic plasticity participates in the formation and maintenance of the firing fields. The results suggest that the formation and short-term stability of firing fields in a new environment involve plasticity that is independent of NMDA receptor activation. By contrast, the long-term stabilization of newly established firing fields required normal NMDA receptor function and, therefore, may be related to other NMDA-dependent processes such as long-term potentiation and spatial learning.
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Base de datos:
MEDLINE
Asunto principal:
Percepción Espacial
/
Receptores de N-Metil-D-Aspartato
/
Células Piramidales
/
Potenciación a Largo Plazo
/
Hipocampo
/
Memoria
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos