Kinetics of bradykinin levels during and after leucocyte filtration of platelet concentrates.
Vox Sang
; 75(1): 18-25, 1998.
Article
en En
| MEDLINE
| ID: mdl-9745149
ABSTRACT
OBJECTIVE:
To measure bradykinin levels in platelet concentrates during and after leucocyte filtration.METHODS:
Platelet concentrates were leukocyte depleted using three different leucocyte-depletion filters selected to represent filters with negative, positive or neutral charge, respectively. Bradykinin levels were analysed before, during and up to 90 min post-filtration.RESULTS:
Significant levels of bradykinin were generated when negatively charged leucocyte depletion filters were used. However, we found a high variation between platelet concentrates prepared from different donors as well as within the same concentrate when this was divided into three aliquots. Generated bradykinin was rapidly degraded in the collection bag and no bradykinin was detectable 60 min post-filtration.CONCLUSION:
Bradykinin generation is more pronounced when negatively charged leucocyte removal filters are used. Due to a rapid degradation of bradykinin in the storage bag, pre-storage filtration should minimise the risk of bradykinin related adverse reactions during transfusion with some filters.
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Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Bradiquinina
/
Depleción Linfocítica
/
Filtración
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Vox Sang
Año:
1998
Tipo del documento:
Article
País de afiliación:
Suecia