Parvovirus B19 infection, hepatitis C virus infection, and mixed cryoglobulinaemia.
Ann Rheum Dis
; 57(7): 422-4, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9797569
ABSTRACT
BACKGROUND:
Infection with human parvovirus B19 (B19) has been reported in a few patients with various vasculitis syndromes. Mixed cryoglobulinaemia (MC), a model of small vessel size vasculitis, may result from numerous infectious diseases, particularly hepatitis C virus (HCV) infection.AIM:
To assess the prevalence of seric B19 infection markers in a large series of patients with MC, with or without HCV infection. PATIENTS ANDMETHODS:
Sixty-four patients were studied essential MC (EMC, n = 19), MC associated with non-infectious diseases (non-essential MC, n = 9), and patients with HCV infection with (HCV-MC, n = 18) or without MC (HCV-no-MC, n = 18). Patients were considered to have MC if two successive determinations of their serum cryoglobulin concentration were above 0.05 g/l. Serum samples were analysed for specific IgG and IgM antibodies to B19 by enzyme immunoassay. B19 DNA detection was performed by polymerase chain reaction using a set of primers located in the VP1 gene, separately in serum and in cryoprecipitates to investigate a possible capture of B19 DNA in cryoprecipitate. The study also looked for a possible enrichment for of IgG antibodies to B19 in MC.RESULTS:
The presence of specific IgG antibodies to B19 was found in 68% EMC, 56% non-essential MC, 78% HCV-MC, and 78% HCV-no-MC. No patient of either group had specific IgM antibodies to B19, or B19 DNA in serum or in cryoprecipitate. Overall, IgG antibodies to B19 were found in 46 of 64 (72%) serum samples, a prevalence quite similar to the prevalence in general adult population (> 60%). A specific enrichment of IgG antibodies to B19 in the MC was not found.CONCLUSION:
These results suggest that B19 infection is neither an aetiological factor of EMC, nor a cofactor that may lead to MC production in patients with chronic HCV infection.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Parvovirus B19 Humano
/
Hepatitis C
/
Infecciones por Parvoviridae
/
Crioglobulinemia
/
Anticuerpos Antivirales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
Ann Rheum Dis
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia