Quantitation of human immunodeficiency virus type 2 DNA in peripheral blood mononuclear cells by using a quantitative-competitive PCR assay.
J Clin Microbiol
; 37(2): 453-6, 1999 Feb.
Article
en En
| MEDLINE
| ID: mdl-9889242
ABSTRACT
A new quantitative-competitive PCR-based human immunodeficiency virus type 2 (HIV-2) proviral DNA assay (QC-PCR) was developed and used to determine the proviral load in HIV-2-infected individuals. Proviral load varied considerably, with means of 1,831 copies per 10(6) peripheral blood mononuclear cells for asymptomatic subjects (n = 19) and 2,587 for AIDS patients (n = 2). HIV-2 viral and proviral loads also varied significantly over time in asymptomatic patients. These data suggest that a high level of virus replication occurs throughout the asymptomatic phase of HIV-2 infection.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
ADN Viral
/
Leucocitos Mononucleares
/
Infecciones por VIH
/
Reacción en Cadena de la Polimerasa
/
VIH-2
/
Provirus
Límite:
Adolescent
/
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Clin Microbiol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Portugal