1.
Phys Chem Chem Phys
; 15(44): 19129-33, 2013 Nov 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24121316
RESUMO
Small amyloid-ß (Aß) oligomers have much higher membrane affinity compared to the monomers, but the structural origin of this functional change is not understood. We show that as monomers assemble into small n-mers (n < 10), Aß acquires a tertiary fold that is consistent with the mature fibrils. This is an early and defining transition for the aggregating peptide, and possibly underpins its altered bioactivity.