Detalhe da pesquisa
1.
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.
PLoS Biol
; 19(7): e3001355, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34319985
2.
A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant Neisseria gonorrhoeae and Other High-Threat Pathogens.
Antimicrob Agents Chemother
; 66(9): e0041422, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35972242
3.
Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Angew Chem Int Ed Engl
; 61(45): e202211498, 2022 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36222275
4.
Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31383669
5.
Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agents.
Bioorg Med Chem Lett
; 27(18): 4426-4430, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28827112
6.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
ACS Infect Dis
; 10(5): 1679-1695, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38581700
7.
Liquid chromatography-mass spectrometry-based protocol to measure drug accumulation in Mycobacterium tuberculosis and its host cell.
STAR Protoc
; 4(1): 101971, 2023 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36598855
8.
Distributable, Metabolic PET Reporting of Tuberculosis.
bioRxiv
; 2023 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37333343
9.
A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
Bioorg Med Chem
; 20(19): 5915-27, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22951255
10.
Rickettsia Aglow: A Fluorescence Assay and Machine Learning Model to Identify Inhibitors of Intracellular Infection.
ACS Infect Dis
; 8(7): 1280-1290, 2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35748568
11.
DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis.
ACS Infect Dis
; 8(3): 612-625, 2022 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35143160
12.
Bayesian Modeling and Intrabacterial Drug Metabolism Applied to Drug-Resistant Staphylococcus aureus.
ACS Infect Dis
; 7(8): 2508-2521, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342426
13.
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Cell Chem Biol
; 27(5): 560-570.e10, 2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32197094
14.
Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
Cell Chem Biol
; 27(2): 172-185.e11, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31711854
15.
Elevation of Fumarate Levels Compromise Redox Control and Viability in Mycobacterium tuberculosis.
Cell Chem Biol
; 24(3): 243-245, 2017 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28306498
16.
Kinetic and structural consequences of the leaving group in substrates of a class C beta-lactamase.
Bioorg Med Chem
; 12(6): 1537-42, 2004 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15018927