MHD flow of nanofluid over moving slender needle with nanoparticles aggregation and viscous dissipation effects.

The study of boundary layer flows over an irregularly shaped needle with small horizontal and vertical dimensions is popular among academics because it seems to have a lot of uses in fields as different as bioinformatics, medicine, engineering, and aerodynamics. With nanoparticle aggregation, magnetohydrodynamics, and viscous dissipation all playing a role in the flow and heat transmission of an axisymmetric TiO2-C2H6O2 nanofluid via a moving thin needle, this article provides guidance on how to employ a boundary layer for this purpose. In this case, we utilized the similarity transformation to change the dimensional partial differential equation into the dimensionless ordinary differential equation. We utilize MATHEMATICA to include shooting using RK-IV methods after identifying the numerical issue. Several characteristics were measured, leading to the discovery of a broad variety of values for things like skin friction coefficients, Nusselt numbers, velocity profiles, and temperature distributions. Velocity profile decreases with increasing values of ϕ,M,e and increases against ε. Temperature profiles enhances with increasing values of ϕ,M,e,ε, and Ec. The reduction in skin friction between a needle and a fluid can be observed when the values of M and ϕ are boosted. Furthermore, it was also noticed an increase in heat transfer on needle surface dramatically when ϕ,e, and M were raised, whereas Ec displayed the opposite effect. The findings of the current study are compared with prior findings for a particular instance in order to confirm the findings. Excellent agreement between the two sets of results is found.

Erratum to "Next-generation and further transgenerational effects of bisphenol A on zebrafish reproductive tissues" [Heliyon 4, (9), (September 2018), Article e00788].

[This corrects the article DOI: 10.1016/j.heliyon.2018.e00788.].

Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: A global health emergency.

According to data compiled by researchers at Johns Hopkins University in Baltimore, Maryland, more than two and half million cases of coronavirus disease 2019 (COVID-19), caused by a newly discovered virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been confirmed on April 20, 2020 (Nature, 2020b). Since the emergence of this infectious disease in Asia (Wuhan, China) late last year, it has been subsequently span to every continent of the world except Antarctica (Rodríguez-Morales et al., 2020). Along with a foothold in every country, the current disease pandemic is disrupting practically every aspect of life all over the world. As the outbreak are continuing to evolve, several research activities have been conducted for better understanding the origin, functions, treatments, and preventions of this novel coronavirus. This review will be a summa of the key features of novel coronavirus (nCoV), the virus causing disease 2019 and the present epidemic situation worldwide up to April 20, 2020. It is expected that this record will play an important role to take more preventive measures for overcoming the challenges faced during this current pandemic.

Next-generation and further transgenerational effects of bisphenol A on zebrafish reproductive tissues.

Next-generation effects and further transgenerational effects of an endocrine disruptor, bisphenol A (BPA), were investigated in zebrafish. The effects of BPA treatment through dietary administration in male and female zebrafish on reproductive factors, such as gonadal activity, fertility, hatching rate and malformation in subsequent generations, were examined through the third filial (F3) generation. BPA treatment of initial generation (F0) not only caused retraction of the ovaries and testes but also lowered the survival rate and increased the rate of malformation of the offspring. Although the overall phenotypes of the surviving first filial (F1) generation offspring of treated fish initially appeared to be normal, we found abnormalities in their reproductive tissues after they matured to adulthood. Although the juveniles were fed a normal diet, the ovaries of 40% of the F1 generation fish remained small and did not develop vitellogenic oocytes. Moreover, sterile male fish appeared at a higher percentage (48%) than control (10%). Adverse transgenerational effects on the fecundity of the second filial (F2) and F3 generation fish were also observed. In each generation, survival rate of embryos were significantly low and abnormal embryos were appeared in offspring from BPA treated ancestral. These results demonstrate that the effects of BPA are transferred to subsequent generations not only through oocytes but also through sperm.

Generation of Transparent Zebrafish with Fluorescent Ovaries: A Living Visible Model for Reproductive Biology.

The transparent zebrafish enables researchers to study the morphology and distribution of cells and tissues in vivo. To capture the dynamic processes of germ cell proliferation and juvenile ovarian development in zebrafish in vivo, we established transgenic (TG) lines to allow us to monitor the changes in the ovaries of living fish. The original transgenic line with ovarian fluorescence was occasionally established. Although the cDNA integrated in the strain was constructed for the expression of enhanced green fluorescent protein (EGFP) driven by the medaka ß-actin promoter, expression of EGFP is restricted to the oocytes and gills in adult fish. Mutant strains with transparent bodies, roy and ruby, were isolated in zebrafish. In this study, we crossed the TG strain with fluorescent ovary with transparent strains and established the TG (ß-actin:EGFP);ruby strain. The strain is highly transparent, and the oocytes are easily observed in living fish. We identified a fluorescent tissue that might contain the undifferentiated germ cells close to the cloaca in the strain. This strain can be used for analysis of ovarian development in vivo.

Simple risk score to detect rural Asian Indian (Bangladeshi) adults at high risk for type 2 diabetes.

AIMS/INTRODUCTION: To develop and evaluate a simple, non-invasive, diabetes risk score for detecting individuals at high risk for type 2 diabetes in rural Bangladesh. MATERIALS AND METHODS: Data from 2,293 randomly selected individuals aged ≥20 years from a cross-sectional study in a rural community of Bangladesh (2009 Chandra Rural Study) was used for model development. The validity of the model was assessed in another rural cross-sectional study (2009 Thakurgaon Rural Study). The logistic regression model used included age, sex, body mass index, waist-to-hip ratio and hypertension status to predict individuals who were at high risk for type 2 diabetes. RESULTS: On applying the developed model to both cohorts, the area under the receiver operating characteristic curve was 0.70 (95% confidence interval 0.68-0.72) for the Chandra cohort and 0.71 (95% confidence interval 0.68-0.74) for the Thakurgaon cohort. The risk score of >9 was shown to have the optimal cut-point to detect diabetes. This score had a sensitivity of 62.4 and 75.7%, and specificity of 67.4 and 61.6% in the two cohorts, respectively. This risk score was shown to have improved sensitivity and specificity to detect type 2 diabetes cases compared with the Thai, Indian, Omani, UK, Dutch, Portuguese and Pakistani diabetes risk scores. CONCLUSIONS: This simple, non-invasive risk score can be used to detect individuals at high risk for type 2 diabetes in rural Bangladesh. Subjects with a score of 9 or above (out of 15) should undergo an oral glucose tolerance test for definitive diagnosis of diabetes.

Prevalence and associated risk indicators of retinopathy in a rural Bangladeshi population with and without diabetes.

PURPOSE: To determine the prevalence of retinopathy among people with normal and abnormal glucose metabolism in a remote rural community of Bangladesh, and to identify the associated risk indicators for developing retinopathy in this population. METHODS: A population-based cross-sectional study was conducted through screening in camp settings, which included a total of 836 participants (468 male and 368 female) aged 30 years or over. Retinopathy was determined by fundus photography. Anthropometric measures (body mass index and waist-to-hip ratio), oral glucose tolerance, glycosylated hemoglobin (HbA1c), blood pressure, lipid profile, serum creatinine and urine albumin creatinine ratio (UACR) were measured. Logistic regression analysis was used with adjustment for potential confounders. RESULTS: The overall prevalence of retinopathy was 5.4% (95% confidence interval, CI, 3.9-6.9). The prevalence rates of retinopathy among diabetic, impaired glucose regulation and non-diabetic subjects were 21.6%, 13% and 3.5%, respectively. Adjusted odds ratios for retinopathy were 2.53 (95% CI 1.52-5.41) for abnormal glucose metabolism and 1.98 (95% CI 1.17-5.63), 1.74 (95% CI 1.09-3.02) and 1.63 (95% CI 1.08-3.12) for hypertension, HbA1c and UACR, respectively. Additionally, age, body mass index, triglyceride and total cholesterol were also found to be significant independent risk indicators for the occurrence of retinopathy in this population. CONCLUSION: A high prevalence of retinopathy was observed in this rural Bangladeshi population. In addition to blood glucose control for diabetes, screening for hypertension, obesity, hyperlipidemia and proteinuria as well as adequate treatment of these risk indicators may prevent retinopathy in rural Bangladeshi populations.

Quality of life of arsenicosis patients in an arsenic-affected rural area in Bangladesh.

The objective of this cross-sectional comparative study was to assess quality of life (QOL) of arsenicosis patients. A total of 104 arsenicosis patients, 104 arsenic-exposed individuals without arsenicosis (nonpatients), and 104 individuals not exposed to arsenic (controls) were interviewed based on a questionnaire constructed based on the WHOQOL-BREF instrument. The facets of life considered for assessing QOL were physical health domain, psychological domain, social relationships domain, and environment domain. All the domain-wise QOL scores of the arsenicosis patients were significantly smaller than those of the controls as well as of the nonpatients. The findings of the study assessing QOL of arsenicosis patients might be helpful to understand the condition and justify for the policy makers to adopt adequate measures to alleviate the sufferings through prevention, treatment, and rehabilitation.