[Postmortem diagnosis of ventricular fibrillation in acute coronary insufficiency]. / Posmertnaia diagnostika fibrilliatsii zheludochkov pri ostroi koronarnoi nedostatochnosti.

Occlusion of coronary artery in dogs has revealed differences in K and Na postmortal distributions in the heart and skeletal muscles after ventricular fibrillation and acute coronary insufficiency. A more dramatic reduction of K and Na content in the heart and skeletal muscles was noted in death caused by heart failure than death caused by ventricular fibrillation. The analysis of autopsy samples showed a more marked reduction in K content in a possible ischemic area (the middle third of anterior wall of the left ventricle) during slow death with short agonal periods as compared to sudden death and a significant reduction of K content in skeletal muscle during slow death in contrast to the absence of changes in sudden death. K and Na measurements in the myocardium and skeletal muscle can be used in addition to catamnesis data for determining the cause of sudden death.

[Prevention of ventricular fibrillation during the acute phase of experimentally induced myocardial infarction by affecting the ion and acid-base balance of the heart]. / Profilaktika fibrilliatsii zheludochkov v ostroi stadii eksperimental'nogo infarkta miokarda putem vozdeistviia na ionnoe i kislotno-osnovnoe ravnovesie v serdtse

For the purpose of prevention of ventricular fibrillation in acute coronary insufficiency a multi-component solution was developed that produces a normalizing effect on the acid-base and ion balance disorders in the heart under ischaemia. The injection of this solution into the left atrium sharply elevated the ventricular fibrillation threshold in cats with an occluded coronary artery. The administration of the solution into the left atrium of dogs following an occlusion of the descending left coronary artery prevented the development of fibrillation in all the experiments, while in the control series of experiments it developed in 62% of cases (p less than 0.001). The solution was decided to posses a high antifibrillation activity that manifests itself when the solution is introduced into the left atrium, and the mechanisms of the beneficial effects of the solution are discussed

[Alcohol consumption and its connection with mortality from cardiovascular diseases in 40-59 years old men (data from 21.5 year prospective study)]. / Potreblenie alkogolia i ego sviaz' so smertnost'iu ot serdechno-sosudistykh zabolevanii muzhchin 40-59 let (dannye prospektivnogo nabliudeniia za 21,5 goda).

AIM: To study contribution of alcohol consumption (AC) to mortality of coronary heart disease (CHD), cerebral stroke (CS), cardiovascular diseases (CVD), overall mortality (OM) in a random population of working males. MATERIAL AND METHODS: The results are available of a 21.5 year cohort study of mortality in a random population of 7,815 male citizens of Moscow and St-Petersburg aged 40-59 years. RESULTS: The attributive risk of AC for mortality of CHD, CS, CVD and OM was 16.6, 14.8, 7.7 and 11.9%, respectively. The lowest relative risk to die of CHD, CVD and OM among the cohort studied was observed in males taking alcohol 168.0 ml per week maximum. CONCLUSION: It is necessary to approach differentially to assessment of AC effects on development of many diseases and further investigations are needed to reveal fine mechanisms of action of different alcohol drinks on human organism.