Detalhe da pesquisa
1.
Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR.
Cell Mol Life Sci
; 76(5): 977-994, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30547226
2.
Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
J Biol Chem
; 293(46): 17685-17704, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29903914
3.
Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.
Biochemistry
; 57(43): 6234-6246, 2018 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30281975
4.
Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.
J Biol Chem
; 292(34): 14147-14164, 2017 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655774
5.
Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.
Biochim Biophys Acta Biomembr
; 1860(5): 1193-1204, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425673
6.
Transmembrane helical interactions in the CFTR channel pore.
PLoS Comput Biol
; 13(6): e1005594, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28640808
7.
Personalised medicine for non-classic cystic fibrosis resulting from rare CFTR mutations.
Eur Respir J
; 56(1)2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32265312
8.
Thermal stability of purified and reconstituted CFTR in a locked open channel conformation.
Protein Expr Purif
; 116: 159-66, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26384709
9.
Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.
FASEB J
; 27(2): 536-45, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23104983
10.
Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration.
FASEB J
; 26(2): 533-45, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21990373
11.
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.
Proc Natl Acad Sci U S A
; 105(9): 3256-61, 2008 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18305154
12.
Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.
J Physiol
; 587(Pt 12): 2875-86, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19403599
13.
Rational Coupled Dynamics Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator.
Chem Sci
; 6(2): 1237-1246, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25685315
14.
Restoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assembly.
J Mol Biol
; 427(1): 106-20, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25083918
15.
A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface.
Mol Biotechnol
; 57(5): 391-405, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25577540
16.
Nucleoside triphosphate pentose ring impact on CFTR gating and hydrolysis.
FEBS Lett
; 518(1-3): 183-8, 2002 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11997043
17.
Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.
J Mol Biol
; 419(1-2): 41-60, 2012 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22406676
18.
Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.
J Mol Biol
; 401(2): 194-210, 2010 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20561529
19.
Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface.
Mol Biotechnol
; 57(5): 406, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25808031
20.
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.
J Biol Chem
; 283(39): 26383-90, 2008 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18658148