Photobiomodulation associated with lipid nanoparticles and hyaluronic acid accelerate the healing of excisional wounds.

Objectives: This article aimed to investigate the effects of the association between photobiomodulation and hyaluronic acid incorporated in lipid nanoparticles in an epithelial lesion model in inflammatory parameters and oxidative stress. Methods: Eighty Wistar rats were randomly assigned to the following groups: epithelial lesion group (EL); EL+PBM; EL+HA; EL+SLNs; EL+SLNs-HA; EL+PBM+HA; EL+PBM+SLNs; EL+PBM+SLNs-HA. The animals were anesthetized with 4% isofluorane after shaving and induced to an epithelial lesion. Topical treatment with a gel containing HA (0.9%) and/or SLNs (10 mg/mL) and with laser irradiation occurred daily for 1 week. Results: The results showed an increase in wound contraction on the seventh day in the LE + LBM + AH-NPL group, a reduction in pro-inflammatory cytokines (IL-6, IL-1ß, and TNF-α), an increase in anti-inflammatory cytokines (IL- 4 and IL-10) and TGF-ß. The levels of pro-inflammatory cytokine IL-4 and TGF-ß also showed an increase in the LE + NPL-AH, LE + FBM + AH, LE + FBM + NPL and LE + FBM + NPL-AH groups. Regarding oxidative stress parameters, the levels of DCF and nitrite decreased in the combined therapy group when compared to the control group, as well as oxidative damage (carbonyl and sulfhydryl). In the antioxidant defense, there was an increase in GSH and SOD in the combination therapy group. Histological analysis showed a reduction in inflammatory infiltrate in the combination therapy group. The number of fibroblasts and the compaction of collagen fibers did not obtain significant responses. Conclusions: Results analyzed together showed that the combined therapy favored the repair process, and that studies can be carried out to enhance the histological analysis therapy favored the tissue repair process and that studies can be carried out to enhance the histological analysis.

Intra-articular treatment with hyaluronic acid associated with gold nanoparticles in a mechanical osteoarthritis model in Wistar rats.

This study aimed to evaluate the effects of intra-articular treatment with hyaluronic acid (HA) associated with GNPs in a mechanical model of osteoarthritis induced by median meniscectomy (MM). Fifty Wistar rats (2 months weighing between 250 and 300 g) were used, divided into five groups of 10 animals each: Sham, osteoarthritis (OA), OA + HA, OA + gold nanoparticles (GNPs), and OA + HA + GNPs. Intra-articular treatment was started 30 days after the model was induced, with a frequency of 2 weeks for 60 days. Fifteen days after the last application, the animals were euthanized with the removal of the joint tissue for biochemical and histological analysis. The model used was able to mimic osteoarthritis, characterized by the presence of high levels of proinflammatory cytokines, oxidative stress, and degeneration of joint surfaces (Grade III, according to SCORE OARSI). The isolated use of HA or GNPs provided beneficial results to the joint; however, only the group subjected to the association between HA and GNPs showed the attenuation of oxidative stress and reduced proinflammatory markers, with a simultaneous increase in levels of anti-inflammatory cytokines and growth factors. Upon histological analysis, only the OA + HA + GNPs group achieved the restoration of the thickness of the joint cartilage with reduced damage and return to the intact joint surface. The results found demonstrated that the association of GNPs with HA was able to reverse the deleterious effects caused by the model by inhibiting the progressive degeneration of joint surfaces, representing a promising treatment for osteoarthritis.

Atuação do enfermeiro na prevenção do câncer do colo de útero em Unidades de Saúde / Performance of the nurse in the prevention of cervical cancer in Health Units

Objetivo: investigar a atuação do Enfermeiro na prevenção do câncer do colo de útero nas Unidades de Saúde da Atenção Básica de município de Espinosa, Minas Gerais. Metodologia: trata-se de um estudo descritivo, exploratório, de natureza qualitativa. Os dados foram coletados no período de setembro a outubro de 2019, com nove enfermeiros submetidos a uma entrevista semiestruturada. Resultados: as ações assistenciais de enfermagem direcionadas para prevenção do câncer de colo do útero são, essencialmente, a educação em saúde e a coleta de material citopatológico para realização do exame. As ações são programadas e organizadas dentro de um fluxo de trabalho previamente estabelecido na rotina das equipes. Conclusão: é importante resignificar as ações de prevenção, tanto para os profissionais como para as mulheres, para romper os estigmas de uma cultura curativista que dificulta a adesão das mulheres ao exame preventivo.

Objective: To investigate the role of nurses in the prevention of cervical cancer in Primary Care Health Units in the municipality of Espinosa, Minas Gerais. Methodology: This is a descriptive, exploratory, qualitative study. Data were collected in the period from September to October 2019, with 09 nurses undergoing a semi-structured interview. Results: the nursing care actions aimed at preventing cervical cancer are essentially health education and the collection of cytopathological material for the examination. The actions are scheduled and organized within a workflow previously established in the teams' routine. Conclusion: it is important to reframe the preventive actions, both for professionals and women, to break the stigmas of a curative culture that makes it difficult for women to adhere to the preventive exam.

Percepção de gestores de escolas públicas e privadas do ensino fundamental sobre programas de saúde bucal nas escolas do distrito Cabula-beirú de Salvador / Manager's perception of public and private school of elementary school about oral health programs in the Cabula- beirú district in Salvador

Objetivo: Descrever a percepção dos gestores de escolas públicas e privadas de ensino fundamental, localizadas no Distrito Sanitário Cabula-Beirú em Salvador, acerca do desenvolvimento de programas de prevenção em saúde bucal em suas unidades escolares. Material e Método: Após a obtenção da relação das escolas, foram sorteadas 30% de cada categoria: estadual, municipal e privada. Os gestores que participaram da pesquisa responderam a um questionário com questões abertas e fechadas. Foi feita uma análise descritiva dos dados quantitativos e uma abordagem qualitativa com base na técnica ?analise de conteúdo?, proposta por Laurence Bardin. A importância atribuída a tais programas relaciona-se a três categorias: educação em saúde bucal, dificuldade de acesso aos serviços odontológicos e evitar problemas odontológicos. Resultados: Identificou-se que 33,3% e 27,2% das escolas estaduais e municipais, respectivamente, desenvolvem programas de promoção de saúde bucal, enquanto que 78,1% das escolas privadas possuem essa atividade. Conclusão: É necessário o estabelecimento de parcerias entre as secretarias de saúde e educação visando a implantação de programas de promoção de saúde bucal nas escolas públicas.

Objective: Describe the perceptions of public and private elementary school principals? from the Cabula- Beirú Health District in Salvador, regarding the development of Oral Health Preventions Programs in school units. Material and methods: A list containing all schools in the area was obtained from state and municipal departments of education, with 30% of each category (state, municipal and private schools) being selected for the survey. The principals from public and private schools answered a questionnaire with both subjective and objective questions. Descriptive analysis of the quantitative data was used, with subjective questions being assayed by Laurence Bardin?s qualitative ?content analysis? technique. The importance assigned to such programs is related to three categories: promoting dental health education, decreasing access difficulties for dental treatments and preventing dental problems. Results: The Results shown that 33,3% and 27,2% of State and Municipal schools maintained Oral Health Programs, respectively, whereas 78,12% of the Private schools take the same action. Conclusion: Therefore, there was concluded that is necessary to the establishment of partnerships between departments of health and education to the implementation of programs to promote oral health in public schools.