Detalhe da pesquisa
1.
Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy.
Antimicrob Agents Chemother
; 67(7): e0048123, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37338374
2.
Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy.
Am J Respir Crit Care Med
; 205(5): 570-579, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34939891
3.
Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment.
Clin Infect Dis
; 75(Suppl 4): S510-S516, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36410384
4.
In Vitro Activity of Bedaquiline and Imipenem against Actively Growing, Nutrient-Starved, and Intracellular Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(12): e0154521, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516254
5.
Comparative Efficacy of Rifapentine Alone and in Combination with Isoniazid for Latent Tuberculosis Infection: a Translational Pharmacokinetic-Pharmacodynamic Modeling Study.
Antimicrob Agents Chemother
; 65(12): e0170521, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606336
6.
New ß-Lactamase Inhibitors Nacubactam and Zidebactam Improve the In Vitro Activity of ß-Lactam Antibiotics against Mycobacterium abscessus Complex Clinical Isolates.
Antimicrob Agents Chemother
; 63(9)2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31209013
7.
In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962331
8.
Treatment-Shortening Effect of a Novel Regimen Combining Clofazimine and High-Dose Rifapentine in Pathologically Distinct Mouse Models of Tuberculosis.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30936097
9.
In Vitro Activity of the New ß-Lactamase Inhibitors Relebactam and Vaborbactam in Combination with ß-Lactams against Mycobacterium abscessus Complex Clinical Isolates.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30642943
10.
Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30745396
11.
Non-classical transpeptidases yield insight into new antibacterials.
Nat Chem Biol
; 13(1): 54-61, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27820797
12.
Impact of Clofazimine Dosing on Treatment Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 62(7)2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29735562
13.
Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.
Proc Natl Acad Sci U S A
; 112(3): 869-74, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25561537
14.
In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis.
J Antimicrob Chemother
; 72(8): 2320-2325, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28575382
15.
Clofazimine has delayed antimicrobial activity against Mycobacterium tuberculosis both in vitro and in vivo.
J Antimicrob Chemother
; 72(2): 455-461, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27798204
16.
Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.
J Infect Dis
; 213(4): 618-27, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416658
17.
Clofazimine Contributes Sustained Antimicrobial Activity after Treatment Cessation in a Mouse Model of Tuberculosis Chemotherapy.
Antimicrob Agents Chemother
; 60(5): 2864-9, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26926638
18.
Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.
J Pathol
; 235(3): 431-44, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25186281
19.
Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations.
Antimicrob Agents Chemother
; 59(4): 2129-35, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25624335
20.
Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 59(6): 3042-51, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25753644