Detalhe da pesquisa
1.
Bioequivalence of rimegepant, a small molecule CGRP receptor antagonist, administered as an oral tablet, a sublingual orally disintegrating tablet, and a supralingual orally disintegrating tablet: two phase 1 randomized studies in healthy adults.
Cephalalgia
; 44(2): 3331024231219505, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38366390
2.
Doravirine and the Potential for CYP3A-Mediated Drug-Drug Interactions.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30783000
3.
Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans.
Xenobiotica
; 49(4): 422-432, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29557716
4.
Concentration-QTc and cardiac safety analysis of single and multiple zavegepant nasal spray doses in healthy participants to support approval.
CPT Pharmacometrics Syst Pharmacol
; 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38812357
5.
Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib.
J Lipid Res
; 53(3): 540-547, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22180633
6.
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
Bioorg Med Chem Lett
; 22(1): 199-203, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22142541
7.
Human Milk and Plasma Pharmacokinetics of Single-Dose Rimegepant 75 mg in Healthy Lactating Women.
Breastfeed Med
; 17(3): 277-282, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35049333
8.
P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(7): 889-897, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35304977
9.
The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease.
Sci Transl Med
; 14(627): eabg3684, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35020407
10.
Effect of raltegravir on estradiol and norgestimate plasma pharmacokinetics following oral contraceptive administration in healthy women.
Br J Clin Pharmacol
; 71(4): 616-20, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21395656
11.
2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: attenuation of hERG binding and improved HDLc-raising efficacy.
Bioorg Med Chem Lett
; 21(9): 2597-600, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21398121
12.
2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.
Bioorg Med Chem Lett
; 21(6): 1890-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21147531
13.
2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.
Bioorg Med Chem Lett
; 21(1): 558-61, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21094047
14.
2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.
Bioorg Med Chem Lett
; 20(1): 346-9, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19914065
15.
2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety.
Bioorg Med Chem Lett
; 20(3): 1019-22, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20036121
16.
Design of a novel class of biphenyl CETP inhibitors.
Bioorg Med Chem Lett
; 20(24): 7469-72, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21041082
17.
A Pharmacokinetic Bioequivalence Study Comparing Sublingual Riluzole (BHV-0223) and Oral Tablet Formulation of Riluzole in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 9(4): 476-485, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31610101
18.
No meaningful drug interactions with doravirine, lamivudine and tenofovir disoproxil fumarate coadministration.
Antivir Ther
; 24(6): 443-450, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31433304
19.
Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects.
Antimicrob Agents Chemother
; 52(12): 4228-32, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18838586
20.
Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies.
Lancet
; 370(9603): 1907-14, 2007 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18068514