Structural growth of zinc oxide nanograins on carbon cloth as flexible electrochemical platform for hydroxychloroquine detection.

Pharmaceutical pollution that imposes a health threat worldwide is making accurate and rapid detection crucial to prevent adverse effects. Herein, binder-free zinc oxide nanograins on carbon cloth (ZnO NGs@CC) have been synthesized hydrothermally and employed to fabricate a flexible electrochemical sensor for the quantification of hydroxychloroquine (HCQ) that is typical pharmaceutical pollution. The characteristics of ZnO NGs@CC were investigated by various in-depth electron microscopic, spectroscopic and electroanalytical approaches. Compared with the pristine CC platform, the ZnO NGs@CC platform exhibits superior electrochemical performance in detecting HCQ with a large oxidation current at a low over-potential of +0.92 V with respect to the Ag/AgCl (Sat. KCl) reference electrode. With the support of desirable characteristics, the fabricated ZnO NGs@CC-based electrochemical sensor for HCQ detection displays good performances in terms of wide sensing range (0.5-116 µM), low detection limit (0.09 µM), high sensitivity (0.279 µA µM-1 cm-2), and strong selectivity. By the resulting 3D hierarchical nanoarchitecture, ZnO NGs@CC has progressive structural advantages that led to its excellent electrochemical performance in sensing applications. Furthermore, the electrochemical sensor is employed to detect HCQ in biological and environmental samples and also achieves good recovery rates. Thus, the designed ZnO NGs@CC demonstrates admirable electrochemical activity toward HCQ real-time monitoring and would be an excellent electrochemical platform for HCQ sensing.

Amine-functionalized diatom frustules: a platform for specific and sensitive detection of nitroaromatic explosive derivative.

In the present study, an attempt was made to develop a proof of concept for the detection of nitroaromatic explosive derivatives through the photoluminescence (PL) quenching process using functionalized diatom frustules as a sensing platform. The diatom frustules are composed of nanostructured, highly porous biogenic silica material and emit strong, visible blue PL upon UV excitation. PL-active biosilica was isolated from the marine diatom Nitzschia sp. and was amine-functionalized to develop a sensing platform. Functionalized diatom frustules were further characterized using field emission scanning electron microscope and a series of spectroscopic methods. When nitroaromatic compounds were bound to the functionalized diatom frustules biosilica, the PL intensity from the functionalized biosilica was partially quenched due to the electrophilic nature of the nitro (-NO) groups. The quenching process confirmed the Meisenheimer complex formation and was investigated by using Fourier transform infrared spectroscopy and time-resolved photoluminescence studies. The developed platform was further evaluated for its sensitivity and specificity, and the limit of detection (LOD) of the assay was determined as 1 µM for a series of nitroaromatic explosive compounds. In conclusion, the developed sensing platform will have great utility in the development of on-site detection platforms for sensitive detection of warfare explosive nitroaromatic compounds from the environment.