1.
Chem Commun (Camb)
; 57(63): 7778-7781, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34263896
RESUMO
Cyclative cleavage of an amine-carbamate self-immolative spacer to deliver a hydroxyl cargo was inhibited by spacer derivatisation with a phosphate monoester handle. This trifunctional spacer was installed in a model anticancer prodrug that showed fast drug release only when incubated with both a protease and a phosphatase enzyme.