The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S.

Caenorhabditis elegans represents a favorite non-mammalian animal model, which is often used to study the effect of foreign substances on living organisms. Its epidermal barrier is a primary biological barrier that protects nematodes from the toxicity of chemicals. In this study, we investigated the effect of Bisphenol A (BPA), an endocrine disrupting chemical, and its structural analog Bisphenol S (BPS), which is often used as a substitute for BPA in some products, on the behavior of C. elegans wild type (N2) and C. elegans bli-1 mutant strain, which is characterized by the production of abnormal cuticle blisters. We found that exposure of C. elegans wild type (N2), as well as its mutant strain bli-1, to selected concentrations of BPA (0.1, 0.5, 1 and 5 µM) and BPS (0.1, 0.5, 1 and 5 µM) resulted in significant changes in reproduction, habituation behavior, and body length of nematodes. Based on our findings, we can conclude that BPS, which was supposed to be a safer alternative to BPA, caused almost identical detrimental effects on C. elegans behavior. Furthermore, compared to the wild type of C. elegans, these effects were more pronounced in the bli-1 strain, which is characterized by a mutation in an individual collagen gene responsible for proper cuticle formation, underlying the role of the epidermal barrier in bisphenol toxicity. Taken together, our data indicate the potential risks of using BPS as a BPA alternative.

CURRENT TRENDS OF RADIATION PROTECTION EQUIPMENT IN INTERVENTIONAL RADIOLOGY.

Interventional radiology represents subspecialty of radiology, which does not use imaging modalities only for diagnostics, but mostly for therapeutic purposes. Realisation of interventional procedures is done through X-rays, which replaces direct visual control done by interventional radiologist or cardiologist. For the targeted reduction of the radiation exposure, the interventional radiology staff use personal protective equipment. Usually, aprons with lead-equivalent are used, which provide protection for 75% of the radiosensitive organs. As the eye lens and thyroid gland belong to the radiosensitive organs, lead eyeglasses and thyroid collar are commonly used for their protection. Cap and gloves with lead-equivalent can be utilised as an additional personal protective equipment, that is commercially available. Innovative protection systems, such as mobile radiation protection cabin and suspended radiation protection, have been designed to ensure better radiation protection and safety. These systems provide the comfort for the interventional radiologists at work, while offering better protection against ionising radiation.

THE IMPORTANCE OF FEEDBACK IN MONITORING PATIENTS' RADIATION DOSES IN MAMMOGRAPHY.

The majority of medical facilities in the Slovak Republic archive diagnostic images of their patients in a picture archiving and communicating system (PACS). Data from the PACS system can be used to analyse patient radiation dose and perform internal and external quality control through dose monitoring software systems. However, appropriate use of such systems requires the provision of feedback and the ability of staff to identify causes of diagnostic reference level exceedances. The present pilot study evaluated the use of a Dose quality control system (DQC) for monitoring the radiation dose of the patients in the ongoing mammography screening, with subsequent identification of alerts triggered by the system.

PRECAUTION IN THE USE OF EFFECTIVE DOSE IN CORONARY CT ANGIOGRAPHY.

The effective dose is a quantity used in clinical practice for statistical evaluation of the radiation dose of patients undergoing different types of examinations. Coronary computed tomography angiography (CCTA) is a specific examination whose calculated effective dose may be subject to several biases. For this reason, it is important to consider factors (different examination techniques, heart rate and patient habitus) that may influence its resulting value. Another critical factor is the methodological procedure for calculating the effective dose and cardiac-specific coefficient used to estimate effective dose from the dose-length product in computed tomography. Because CCTA is increasingly used in cardiology, it is recommended that the chest coefficient be replaced with a new cardiac coefficient when calculating the effective dose.

The importance of public health in radiology and radiation protection.

The ionizing radiation belongs to the basic physical factors that can be measured. We forget often about its risks and the possible damage to our health. The imaging methods which use the ionizing radiation increase the diagnostics quality and they have become a certainty for many medical workers. Therefore, they are being used without rational thinking many times. With this is related to increasing the cumulative dose of patients. Next problem can be radiation safety knowledge of medical workers. The enormous increase in the use of sources ionizing radiation in medicine and rapid development, there may be a disproportionate acquisition of radiation safety knowledge of healthcare workers. At the same time, constant attention must be paid to the biological effects of radiation and realize epidemiology studies. In all the areas mentioned the public health has space. However, it is sad that presently, the radiation safety is not considered important enough in Public Health.  Based on many sources, it is safe to say that this is a major problem, because the public health itself can play an important role in radiation safety. It is important to point out, that safety and effectivity of using the source of ionizing radiation is one of the main components of Good Medical Practice.

ESTIMATION OF DIAGNOSTIC REFERENCE LEVELS FOR CT CORONAROGRAPHY IN SLOVAKIA.

The coronary CT angiography (CCTA) is a frequent diagnostic method connected with large variability of effective dose. Therefore, it is the type of examination where optimization is very important and the use of a national diagnostic reference level (DRL) recommended. In Slovakia the DRL for interventional radiology examinations until now fails. The objective of our study was to propose the national DRL for CCTA examinations in Slovak Republic, on the basis of a cross-sectional multicenter study, performed in four departments of radiology. The study was realized in 2014-16 in a sample of 1725 patients undergoing CCTA examination. The proposed DRL expressed by CTDIVOL is 45 mGy and of DLP is 510 mGy cm.