Detalhe da pesquisa
1.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-ß pathology.
Cell Mol Life Sci
; 80(7): 178, 2023 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306762
2.
Revisiting the roles of cAMP signalling in the progression of prostate cancer.
Biochem J
; 480(20): 1599-1614, 2023 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37830741
3.
Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation and alterations in DNA repair: implications for therapeutic strategies.
Br J Cancer
; 129(9): 1462-1476, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37740039
4.
Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme.
Proc Natl Acad Sci U S A
; 117(1): 677-688, 2020 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31871190
5.
Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.
J Mol Cell Cardiol
; 165: 86-102, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34999055
6.
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Proc Natl Acad Sci U S A
; 116(27): 13320-13329, 2019 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31209056
7.
Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A.
J Biol Chem
; 295(13): 4303-4315, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32098872
8.
Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function.
Clin Sci (Lond)
; 134(15): 2019-2035, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32706027
9.
A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins.
J Biol Chem
; 293(44): 16964-16983, 2018 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30194280
10.
Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes.
Biochem Soc Trans
; 47(5): 1405-1414, 2019 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31506329
11.
Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches.
Biochem Soc Trans
; 47(5): 1557-1565, 2019 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31642904
12.
Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.
BMC Cancer
; 19(1): 266, 2019 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30909892
13.
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Mol Cell
; 42(1): 84-95, 2011 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21474070
14.
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.
Proc Natl Acad Sci U S A
; 113(28): 7786-91, 2016 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357676
15.
Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.
J Biol Chem
; 292(42): 17190-17202, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28882895
16.
Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.
Biochem J
; 474(4): 597-609, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27993970
17.
A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase.
Int J Mol Sci
; 19(12)2018 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30563079
18.
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
J Neurosci
; 36(34): 8936-46, 2016 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559174
19.
Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.
J Gen Virol
; 98(2): 251-265, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284242
20.
Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
Circ Res
; 117(8): 707-19, 2015 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26243800