COVID-19 and working from home-related changes in physical activity in Sydney, Australia.

ISSUES ADDRESSED: Evidence on how COVID-19 lockdowns impacted physical activity (PA) is mixed. This study explores changes in PA following initial mobility restrictions, and their subsequent relaxation, in a sample of Sydney (Australia) residents using a natural experiment methodology. METHODS: Participants' health and travel behaviours were collected pre-pandemic in late 2019 (n = 1937), with follow-up waves during the pandemic in 2020 (n = 1706) and 2021 (n = 1514). Linear mixed-effects models were used to analyse changes in weekly duration of PA between the three waves. RESULTS: Compared with pre-pandemic, average weekly PA increased in 2021 by 42.6 min total PA (p = .001), 16 min walking PA (p = .02), and 26.4 min moderate-vigorous PA (MVPA) (p = .003). However, average weekly sessions of PA decreased in 2020 and remained lower in 2021. For participants who were sufficiently active in 2019, weekly total PA (-66.3 min) MVPA (-43.8 min) decreased in 2020 compared to pre-pandemic. Conversely, among participants who were insufficiently active in 2019, average weekly PA increased in both 2020 (total PA, +99.1 min; walking PA, +46.4 min; MVPA +52.8 min) and 2021 (total PA, +117.8 min; walking PA, +58.4 min; MVPA +59.2 min), compared to 2019. Participants who did more work from home increased their average weekly total PA in 2021 compared to pre-pandemic (+45.3 min). CONCLUSION: These findings reveal the complex variability in PA behaviour brought about by the pandemic. SO WHAT?: Strategies to support the population in achieving sufficient PA must focus on maintaining an appetite for PA as we move out of the pandemic and on promoting more frequent PA sessions.

Protamine dose to neutralize heparin at the completion of cardiopulmonary bypass can be reduced significantly without affecting post-operative bleeding.

BACKGROUND: Systemic anticoagulation with heparin during cardiopulmonary bypass (CPB) should be neutralized by protamine administration to restore normal hemostasis. Our previous study showed the protamine-to-heparin ratio (P-to-H) of 1:1 (1 mg protamine:100 IU circulating heparin; 1.0 Ratio) is likely an overestimation. Thus, we reduced the P-to-H in the HMS Plus Hemostasis Management System to 0.9:1 (0.9 Ratio) for 5 months and then to 0.8:1 (0.8 Ratio). We monitored post-operative (post-op) bleeding in the setting of reduced protamine dose (PD). METHODS: We performed a retrospective study of 632 patients (209 for the 1.0 Ratio, 211 for 0.9 Ratio, 212 for 0.8 Ratio group) who underwent cardiac surgery to measure the reduction of PD and how it affects 24-hour (24 h) post-op chest tube output. We also analyzed the entire data set to explore whether further reduction of P-to-H is warranted. RESULTS: While there was no difference in the indexed heparin dose among the three groups, we achieved a significant reduction in the indexed actual protamine dose (APDi) by 24% (0.9 Ratio) and 31% (0.8 Ratio) reductions compared to the 1.0 Ratio group. On average, APDi was 88 ± 22, 67 ± 18, and 61 ± 15 mg/m2 in the 1.0, 0.9, and 0.8 Ratio groups, respectively. We found no significant difference in 24 h post-op bleeding among the three groups. CONCLUSION: 1.0 Ratio at the completion of CPB is likely an excessive administration of protamine. With the stepwise reduction of PD, we observed no increase in post-op bleeding, which may indicate that no meaningful increase in heparin rebound occurred. In addition, further analysis of the entire data set demonstrates that a 0.75 Ratio is likely sufficient to neutralize the heparin completely.

Mandibular condylar hyperplasia and its correlation with vascular endothelial growth factor.

BACKGROUND: Condylar hyperplasia (CH) is a rare condition characterised by excessive unilateral growth of the mandibular condyle after cessation of growth on the contralateral side causing facial asymmetry, being more prevalent in the second and third decades. OBJECTIVE: The aim of this study was to determine the utility of vascular endothelial growth factor (VEGF-A) as a diagnostic and prognostic factor in condylar hyperplasia, and to determine its potential viability as a therapeutic target. METHODS: This is a case-control study, where 17 mandibular condyles specimens were collected from 17 patients treated for active mandibular condyle hyperplasia and three unaffected human mandibular condyles from cadavers will serve as the control group. The samples were immunostained with VEGF-A antibody and evaluated on both quantity and intensity of staining. RESULTS: VEGF-A was qualitatively found to be greatly upregulated in patients with condylar hyperplasia. CONCLUSION: VEGF-A was qualitatively found to be upregulated in patients affected by CH, validating VEGF-A as a potential diagnostic, prognostic and therapeutic target.

Exploring how worthwhile the things that you do in life are during COVID-19 and links to well-being and working from home.

The COVID-19 pandemic has had a significant impact on the way we work and live, with working from home becoming more than the occasional desire but a regular feature of work and life. While an increasing number of research studies have promoted the virtues of what is often described as the positive unintended consequences of the pandemic, there are also downsides, especially during periods of imposed restrictions on the ability to get out and about, that have broadly been described as impacting mental health and life's worth. In this paper we use data collected in New South Wales during September 2020 and June 2021, seven and 16 months after the pandemic began, to obtain an understanding of the extent to which the pandemic has impacted on how worthwhile things done in life are for workers. We investigate whether there is a systematic behavioural link with working from home, reduced commuting linked to distance to work, and various socio-economic characteristics. The evidence suggests that the opportunity to have reduced commuting activity linked to working from home and increased perceived work-related productivity have contributed in a positive way to improving the worth status of life, offsetting some of the negative consequences of the pandemic.

The impact of COVID-19 and working from home on the workspace retained at the main location office space and the future use of satellite offices.

There exists a substantial amount of research on the impact that the COVID-19 pandemic has had on significant changes in the location at which work takes place, especially working from home (WFH). There has been, however, very little systematic consideration given to the relationship between the substantial increase in WFH and the responses taken by organisations in reviewing their office (workspace) capacity needs in the future, including a switch of the mix of utilising workspace in the main office(s) and satellite office locations. The main aim of this paper is to explore the extent to which levels of working from home and increased use of rented satellite office space will be linked to changes in the amount of workspace required at the main office that was used pre-COVID-19. Using data from 459 businesses for three periods for pre-COVID-19, April 2022 (25 months after the outbreak of the pandemic) and stated intentions for 2023, we develop a random effects regression model for the Greater Sydney Metropolitan Area in which we identify some of the influences on the downsizing or not of the main office(s) work space, and comment on what we see as the most likely scenario for WFH and work space in the main office and rented satellite office space under the 'next normal'. The findings can be used to inform future commuting travel as well as changes in land use activity at specific locations, including possible reallocation of existing office space to other activity uses.

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.

Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-mediated PrP suppression extends survival and delays disease onset in intracerebrally prion-infected mice in both prophylactic and delayed dosing paradigms. Here, we examine the efficacy of this therapeutic approach across diverse paradigms, varying the dose and dosing regimen, prion strain, treatment timepoint, and examining symptomatic, survival, and biomarker readouts. We recapitulate our previous findings with additional PrP-targeting ASOs, and demonstrate therapeutic benefit against four additional prion strains. We demonstrate that <25% PrP suppression is sufficient to extend survival and delay symptoms in a prophylactic paradigm. Rise in both neuroinflammation and neuronal injury markers can be reversed by a single dose of PrP-lowering ASO administered after the detection of pathological change. Chronic ASO-mediated suppression of PrP beginning at any time up to early signs of neuropathology confers benefit similar to constitutive heterozygous PrP knockout. Remarkably, even after emergence of frank symptoms including weight loss, a single treatment prolongs survival by months in a subset of animals. These results support ASO-mediated PrP lowering, and PrP-lowering therapeutics in general, as a promising path forward against prion disease.

Working from home in Australia in 2020: Positives, negatives and the potential for future benefits to transport and society.

The year 2020 has been marked by the most extraordinary event we have witnessed since World War II. While other health threats and geographical disasters have occurred, none have been on the global scale of COVID-19. Although many countries have experienced more than one wave of the pandemic throughout 2020, Australia has been largely able to contain the impact of the virus. While there are many reasons for this, a key component of reducing transmission has been restrictions on movement, and the widespread adoption of working from home (WFH) by those who can. In describing the experience Australian's have had with working from home across 2020, via three waves of data collection, we find that WFH become a positive unintended consequence in contributing to the future management of the transport network, especially in larger metropolitan areas. Evidence suggests that support for WFH will be continuing in the form of a hybrid work model with more flexible working times and locations, linked to largely positive experiences of WFH during 2020, an improved wellbeing of employees, and no loss of productivity to the economy. We highlight potential future benefits of WFH to society, including significant implications for congestion and crowding, concluding that WFH is a formidable transport policy lever that must become embedded in the psyche of transport planners and decision makers so that we can gain some benefit from the pandemic.

The impact of working from home on modal commuting choice response during COVID-19: Implications for two metropolitan areas in Australia.

The need to recognise and account for the influence of working from home on commuting activity has never been so real as a result of the COVID-19 pandemic. Not only does this change the performance of the transport network, it also means that the way in which transport modellers and planners use models estimated on a typical weekday of travel and expand it up to the week and the year must be questioned and appropriately revised to adjust for the quantum of working from home. Although teleworking is not a new phenomenon, what is new is the ferocity by which it has been imposed on individuals throughout the world, and the expectation that working from home is no longer a temporary phenomenon but one that is likely to continue to some non-marginal extent given its acceptance and revealed preferences from both many employees and employ where working from home makes good sense. This paper formalises the relationship between working from home and commuting by day of the week and time of day for two large metropolitan areas in Australia, Brisbane and Sydney, using a mixed logit choice model, identifying the influences on such choices together with a mapping model between the probability of working from home and socioeconomic and other contextual influences that are commonly used in strategic transport models to predict demand for various modes by location. The findings, based on Wave 3 (approximately 6 months from the initial outbreak of the pandemic) of an ongoing data collection exercise, provide the first formal evidence for Australia in enabling transport planners to adjust their predicted modal shares and overall modal travel activity for the presence of working from home.

Characterising public transport shifting to active and private modes in South American capitals during the COVID-19 pandemic.

During the year 2020, the COVID-19 pandemic affected mobility around the world, significantly reducing the number of trips by public transport. In this paper, we study its impact in five South American capitals (i.e., Bogotá, Buenos Aires, Lima, Quito and Santiago). A decline in public transport patronage could be very bad news for these cities in the long term, particularly if users change to less sustainable modes, such as cars or motorbikes. Notwithstanding, it could be even beneficial if users selected more sustainable modes, such as active transport (e.g., bicycles and walking). To better understand this phenomenon in the short term, we conducted surveys in these five cities looking for the main explanation for changes from public transport to active and private modes in terms of user perceptions, activity patterns and sociodemographic information. To forecast people's mode shifts in each city, we integrated both objective and subjective information collected in this study using a SEM-MIMIC model. We found five latent variables (i.e., COVID-19 impact, Entities response, Health risk, Life related activities comfort and Subjective well-being), two COVID-19 related attributes (i.e., new cases and deaths), two trip attributes (i.e., cost savings and time), and six socio-demographic attributes (i.e., age, civil status, household characteristics, income level, occupation and gender) influencing the shift from public transport to other modes. Furthermore, both the number of cases and the number of deaths caused by COVID-19 increased the probability of moving from public transport to other modes but, in general, we found a smaller probability of moving to active modes than to private modes. The paper proposes a novel way for understanding geographical and contextual similarities in the pandemic scenario for these metropolises from a transportation perspective.

Australia 6 months after COVID-19 restrictions part 2: The impact of working from home.

This paper (Part 2 in the paper series), building on earlier studies examining the Australian response, extends on findings related to travel activity, commuting, and attitudes towards COVID-19 measures (Part 1 in the paper series). In this paper we focus in detail on the impact of, and experiences with, working from home (WFH), perhaps the largest of the positive unintended consequence of the pandemic, with respect to transport, and a key lens through which the changing patterns in travel activity and attitudes discussed in Part 1 need to be understood. We conclude that through the widespread adoption of WFH as a result of nationwide public health orders, there is evidence emerging that WFH is now seen as an appealing instrument of change by employees and employers, there is growing support to continue to support WFH into the future. This represents a significant potential contribution to the future management of the transport network, especially in larger metropolitan areas. We also discuss policy implications of this result and what the international community may take from the Australian experience.

Australia 6 months after COVID-19 restrictions- part 1: Changes to travel activity and attitude to measures.

While many countries have experienced more than one wave of the pandemic throughout 2020, Australia has been able to contain the virus in a way that makes it a stand out (with New Zealand) in the way that it has been contained, with an exception in Victoria linked to failed quarantine procedures for travellers returning from overseas. Through descriptive analysis, this paper builds on earlier papers by the authors on the Australian response, with a focus on the changing dynamics of travel activity, concern with public transport, and attitudes surrounding activity given the perception of risk of COVID-19 and the level of public support for regulatory intervention and restrictions on movement. We find that Australia continues to suppress travel, particularly that for commuting, that comfort in completing day-to-day activities continues to rise (with the exception of Victoria where confidence feel significantly), and while support for intervention measures remains high, there has been an erosion in sentiment. As with previous work, we discuss what this might mean for future transport policy, and attempt to draw lessons from the Australian experience.

Targeted ordering of investigations reduces costs of treatment for surgical inpatients.

BACKGROUND: Laboratory testing forms an important part of diagnostic investigation in modern medicine; however, the overuse of 'routine blood tests' can result in significant potential harm and financial cost to the patient and the healthcare system. In 2018, a new protocol targeting the ordering of investigations was implemented within the General Surgical Teams of Wollongong Hospital in New South Wales, an Australian tertiary referral hospital, to reduce the number of 'routine blood tests' as a quality improvement initiative. OBJECTIVE: To identify whether there was a reduction in the number of 'routine blood tests' and associated costs following implementation of the new protocol. METHODS: The protocol involved regular review of the laboratory investigations being ordered for the following day with a senior team member. The medical records of all patients admitted under the general surgery service at Wollongong Hospital were retrospectively reviewed over two 10-week periods in 2017 and 2018 (control and study, respectively). The casemix was categorized into Minor, Intermediate, Major or Unscored, depending on case complexity coding. RESULTS: A total of 838 patients were identified during the control period (2017) and 805 patients were identified during the study period (2018). Ten thousand and thirty tests were included in the control period, compared to 8610 over the study period, resulting in a 16% (or greater) reduction in 'routine blood tests' per patient, per day of admission and a 6% reduction in costs in the study group (P < 0.001). CONCLUSION: Targeted ordering of investigations with personalized education and feedback to junior staff during review of clinical status of each patient as a part of normal workflow can reduce inappropriate ordering of 'routine blood tests' and associated costs to the patient and the healthcare system.

Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis.

Aberrant accumulation of misfolded Cu, Zn superoxide dismutase (SOD1) is a hallmark of SOD1-associated amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative disease. While recent discovery of nonnative trimeric SOD1-associated neurotoxicity has suggested a potential pathway for motor neuron impairment, it is yet unknown whether large, insoluble aggregates are cytotoxic. Here we designed SOD1 mutations that specifically stabilize either the fibrillar form or the trimeric state of SOD1. The designed mutants display elevated populations of fibrils or trimers correspondingly, as demonstrated by gel filtration chromatography and electron microscopy. The trimer-stabilizing mutant, G147P, promoted cell death, even more potently in comparison with the aggressive ALS-associated mutants A4V and G93A. In contrast, the fibril-stabilizing mutants, N53I and D101I, positively impacted the survival of motor neuron-like cells. Hence, we conclude the SOD1 oligomer and not the mature form of aggregated fibril is critical for the neurotoxic effects in the model of ALS. The formation of large aggregates is in competition with trimer formation, suggesting that aggregation may be a protective mechanism against formation of toxic oligomeric intermediates.

The value of lateral glenohumeral offset in predicting construct failure in proximal humerus fractures following internal fixation.

BACKGROUND: Proximal humerus fractures are the third most common osteoporosis defining injury in the United States, yet operative fixation of these injuries remains technically challenging. Although several modifiable and nonmodifiable risk factors are correlated with failure of proximal humerus fixation, no study has investigated whether failure to restore glenohumeral offset plays a part in fixation failure. The goals of this study are: (1) to determine if lateral glenohumeral offset (LGHO) and humeral head diameter (HHD) can be measured radiographically with accuracy between observers, (2) to observe whether there is a correlation between failure to operatively restore an anatomic LGHO:HHD ratio and failure of fixation, and (3) if there is a correlation, can any recommendations be made in regard to the ideal LGHO:HHD ratio. METHODS: Retrospective review found 183 patients meeting inclusion criteria who underwent operative fixation for proximal humerus fractures between 2005 and 2018. Patients suffering construct failure requiring reoperation were compared with clinically successful surgeries on the basis of age, sex, fracture morphology, head-shaft angle, smoking history, presence or absence of a calcar screw, and LGHO:HHD ratio. The groups were compared using a combination of Student t-tests, χ2, and bivariate and multivariate logistic regression analyses where appropriate. The Student t-test and intraclass correlation coefficient were both used to assess interobserver reliability. RESULTS: We found that LGHO and HHD can be measured by independent observers accurately (intraclass correlation coefficient = 0.80, 95% confidence interval: 0.65-0.89). Patients suffering implant failure had a significantly lower LGHO:HHD ratios compared with those who did not (0.94 vs. 1.03, P ≤ .001). The LGHO:HHD ratio was an independent predictor of implant failure even after controlling for other potential risk factors. Patients with an LGHO:HHD of 1.0 or above have a <10% chance of failure compared with a 20% risk with a ratio of 0.9 and a 40% risk at 0.8. CONCLUSION: We found the LGHO:HHD ratio to be an independent predictor for construct failure after plate and screw fixation of proximal humerus fractures. Efforts should be made to restore an anatomic ratio of at least 1.0 to minimize the risk of failure.

Union rate, complication rate, and opioid usage after Vancouver B periprosthetic femur fractures: a comparison of fracture types.

INTRODUCTION: Periprosthetic femur fractures are complex injuries that can be difficult to treat and recover from. With a growing number of total hip arthroplasties (THA) and revision arthroplasties being performed in an aging population, the incidence of these injuries is on the rise. Multiple studies exist detailing outcomes associated with periprosthetic femur fractures after THA, but no study has directly compared the post-operative course between fracture types as classified by the Vancouver classification system. This study compares the three Vancouver B fracture types to see if any type is associated with an increase in post-operative complications than others. MATERIALS AND METHODS: This retrospective chart review was conducted at a suburban orthopedic surgery department. Overall, 122 patients who presented to our hospital with periprosthetic proximal femur fractures after hip arthroplasty over the past 13 years were reviewed. Patients were included if they underwent surgical stabilization of their femur fracture. Patients were excluded if they underwent non-operative treatment or had missing chart information. For each patient, demographic information, fracture information, surgical information, post-operative course, and post-operative opioid usage were recorded and compared among groups. RESULTS: Overall, 88 fractures were included. Fifty-five (62.5%) were Vancouver type B1, 27 (30.7%) were Vancouver type B2, and 6 (6.8%) were Vancouver type B3. Most of our patients were female (n = 62, 70.5%) and older than 81 years of age (n = 53, 60.2%) with uncemented prosthesis (n = 83, 94.3%). All three fracture groups had statistically similar union rates (p = 0.77), infection rates (p = 0.32), subsequent fractures (p = 0.63), repeat surgeries (p = 0.64), and post-operative opioid use (measured in milli-morphine equivalents) after surgical stabilization (p = 0.96). CONCLUSIONS: While periprosthetic femur fractures after hip arthroplasty are associated with high complication rates and poor outcomes, there is no difference in union rate, infection rate, subsequent fractures, repeat surgery rate, and opioid usage between the different Vancouver B fracture types. LEVEL OF EVIDENCE: Prognostic level III.

Working from home and its implications for strategic transport modelling based on the early days of the COVID-19 pandemic.

The COVID-19 pandemic has changed the way we go about our daily lives in ways that are unlikely to return to the pre-COVID-19 levels. A key feature of the COVID-19 era is likely to be a rethink of the way we work and the implications this may have on commuting activity. Working from home (WFH) has been the 'new normal' during the period of lockdown, except for essential services that require commuting. In recognition of the new normal as represented by an increasing amount of WFH, this paper develops a model to identify the incidence of WFH and what impact this could have on the amount of weekly one-way commuting trips by car and public transport. Using Wave 1 of an ongoing data collection effort done at the height of the restrictions in March and April 2020 in Australia, we develop a number of days WFH ordered logit model and link it to a zero-inflated Poisson (ZIP) regression model for the number of weekly one-way commuting trips by car and public transport. Scenario analysis is undertaken to highlight the way in which WFH might change the amount of commuting activity when restrictions are relaxed to enable changing patterns of WFH and commuting. The findings will provide one reference point as we continue to undertake similar analysis at different points through time during the pandemic and after when restrictions are effectively removed.

Public transport trends in Australia during the COVID-19 pandemic: An investigation of the influence of bio-security concerns on trip behaviour.

This paper draws on findings from an Australia-wide survey with data collected in three waves throughout 2020 to explore the impact of COVID-19 on public transport trends in metropolitan areas of Australia. Following consideration of the public transport sector response to the pandemic and the emerging literature context, we explore three principal questions: (i) How has weekly travel composition changed across the waves? (ii) How has level of concern with using public transport changed over the course of the pandemic given new bio-security concerns? and (iii) How has attitudes to risk been associated with the changes in PT use? A key finding is that concerns over bio-security issues around public transport are enduring, that concern about hygiene is significantly negatively related to public transport use and that those with higher concern about the hygiene of public transport also held higher concern about COVID-19 at work. Even as COVID-19 restrictions are eased, both concern about crowds and hygiene have a significant and negative correlation with public transport use. Concluding remarks are offered on what might need to happen for public transport patronage to start returning.

Impact of COVID-19 on the number of days working from home and commuting travel: A cross-cultural comparison between Australia, South America and South Africa.

The COVID-19 pandemic has changed the way we go about our daily lives in ways that are unlikely to return to the pre-COVID-19 levels. A key feature of the COVID-19 era is likely to be a rethink of the way we work and the implications on commuting activity. Working from home (WFH) has been the 'new normal' during the period of lockdown, except for essential services that require commuting. In recognition of the new normal as represented by an increasing amount of WFH, this paper develops a model to identify the incidence of WFH and what impact this could have on the number of weekly commuting trips. Using data collected in eight countries (Argentina, Australia, Brazil, Chile, Colombia, Ecuador, Peru and South Africa), we developed a Poisson regression model for the number of days individuals worked from home during the pandemic. Simulated scenarios quantify the impact of the different variables on the probability of WFH by country. The findings provide a reference point as we continue to undertake similar analysis at different points through time during the pandemic and after when restrictions are effectively removed.

Slowly coming out of COVID-19 restrictions in Australia: Implications for working from home and commuting trips by car and public transport.

With the onset of COVID-19 restrictions and the slow relaxing of many restrictions, it is imperative that we understand what this means for the performance of the transport network. In going from almost no commuting, except for essential workers, to a slow increase in travel activity with working from home (WFH) continuing to be both popular and preferred, this paper draws on two surveys, one in late March at the height of restrictions and one in late May as restrictions are starting to be partially relaxed, to develop models for WFH and weekly one-way commuting travel by car and public transport. We compare the findings as one way to inform us of the extent to which a sample of Australian residents have responded through changes in WFH and commuting. While it is early days to claim any sense of a new stable pattern of commuting activity, this paper sets the context for ongoing monitoring of adjustments in travel activity and WFH, which can inform changes required in the revision of strategic metropolitan transport models as well as more general perspectives on future transport and land use policy and planning.

Insights into the impact of COVID-19 on household travel and activities in Australia - The early days under restrictions.

When 2020 began, we had no idea what was to unfold globally as we learnt about the Novel-Coronavirus in Wuhan, in the Hubei province of China. As this virus spread rapidly, it became a matter of time before many countries began to implement measures to try and contain the spread of the disease. COVID-19 as it is referred to, resulted in two main approaches to fighting the viral pandemic, either through a progressive set of measures to slow down the number of identified cases designed to 'flatten the curve' over time (anticipated to be at least six months), or to attack it by the severest of measures including a total lock-down and/or herding exposure to fast track 'immunisation' while we await a vaccine. The paper reports the findings from the first phase of an ongoing survey designed to identify the changing patterns in travel activity of Australian residents as a result of the stage 2 restrictions imposed by the Australian government. The main restrictions, in addition to social distancing of at least 1.5 m, are closure of entry to Australia (except residents returning), and closure of non-essential venues such as night clubs, restaurants, mass attendee sporting events, churches, weddings, and all social gatherings in any circumstance. With some employers encouraging working from home and others requiring it, in addition to job losses, and many children attending school online from home, the implications on travel activity is extreme. We identify the initial impacts associated with the first month of stricter social distancing measures introduced in Australia.