Pesquisa | Portal de Pesquisa da BVS

1.

DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.

Cobo, Isidoro; Tanaka, Tiffany N; Chandra Mangalhara, Kailash; Lana, Addison; Yeang, Calvin; Han, Claudia; Schlachetzki, Johannes; Challcombe, Jean; Fixsen, Bethany R; Sakai, Mashito; Li, Rick Z; Fields, Hannah; Mokry, Michal; Tsai, Randy G; Bejar, Rafael; Prange, Koen; de Winther, Menno; Shadel, Gerald S; Glass, Christopher K.

Immunity ; 55(8): 1386-1401.e10, 2022 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-35931086

2.

Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.

Duncavage, Eric J; Bagg, Adam; Hasserjian, Robert P; DiNardo, Courtney D; Godley, Lucy A; Iacobucci, Ilaria; Jaiswal, Siddhartha; Malcovati, Luca; Vannucchi, Alessandro M; Patel, Keyur P; Arber, Daniel A; Arcila, Maria E; Bejar, Rafael; Berliner, Nancy; Borowitz, Michael J; Branford, Susan; Brown, Anna L; Cargo, Catherine A; Döhner, Hartmut; Falini, Brunangelo; Garcia-Manero, Guillermo; Haferlach, Torsten; Hellström-Lindberg, Eva; Kim, Annette S; Klco, Jeffery M; Komrokji, Rami; Lee-Cheun Loh, Mignon; Loghavi, Sanam; Mullighan, Charles G; Ogawa, Seishi; Orazi, Attilio; Papaemmanuil, Elli; Reiter, Andreas; Ross, David M; Savona, Michael; Shimamura, Akiko; Skoda, Radek C; Solé, Francesc; Stone, Richard M; Tefferi, Ayalew; Walter, Matthew J; Wu, David; Ebert, Benjamin L; Cazzola, Mario.

Blood ; 140(21): 2228-2247, 2022 11 24.

Artigo em Inglês | MEDLINE | ID: mdl-36130297

3.

SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.

Malcovati, Luca; Stevenson, Kristen; Papaemmanuil, Elli; Neuberg, Donna; Bejar, Rafael; Boultwood, Jacqueline; Bowen, David T; Campbell, Peter J; Ebert, Benjamin L; Fenaux, Pierre; Haferlach, Torsten; Heuser, Michael; Jansen, Joop H; Komrokji, Rami S; Maciejewski, Jaroslaw P; Walter, Matthew J; Fontenay, Michaela; Garcia-Manero, Guillermo; Graubert, Timothy A; Karsan, Aly; Meggendorfer, Manja; Pellagatti, Andrea; Sallman, David A; Savona, Michael R; Sekeres, Mikkael A; Steensma, David P; Tauro, Sudhir; Thol, Felicitas; Vyas, Paresh; Van de Loosdrecht, Arjan A; Haase, Detlef; Tüchler, Heinz; Greenberg, Peter L; Ogawa, Seishi; Hellstrom-Lindberg, Eva; Cazzola, Mario.

Blood ; 136(2): 157-170, 2020 07 09.

Artigo em Inglês | MEDLINE | ID: mdl-32347921

4.

Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies.

Mughal, Tariq I; Pemmaraju, Naveen; Bejar, Rafael; Gale, Robert P; Bose, Prithviraj; Kiladjian, Jean-Jacques; Prchal, Josef; Royston, Daniel; Pollyea, Daniel; Valent, Peter; Brümmendorf, Tim H; Skorski, Tomasz; Patnaik, Mrinal; Santini, Valeria; Fenaux, Pierre; Kucine, Nicole; Verstovsek, Srdan; Mesa, Ruben; Barbui, Tiziano; Saglio, Guiseppe; Van Etten, Richard A.

Hematol Oncol ; 40(4): 491-504, 2022 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-35368098

5.

MDS overlap disorders and diagnostic boundaries.

Tanaka, Tiffany N; Bejar, Rafael.

Blood ; 133(10): 1086-1095, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30670443

6.

Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation.

Stoner, Samuel A; Yan, Ming; Liu, Katherine Tin Heng; Arimoto, Kei-Ichiro; Shima, Takahiro; Wang, Huan-You; Johnson, Daniel T; Bejar, Rafael; Jamieson, Catriona; Guan, Kun-Liang; Zhang, Dong-Er.

Blood ; 134(20): 1730-1744, 2019 11 14.

Artigo em Inglês | MEDLINE | ID: mdl-31434702

7.

Adoptive transfer of neoantigen-specific T-cell therapy is feasible in older patients with higher-risk myelodysplastic syndrome.

Tanaka, Tiffany N; Ferrari, Valentina; Tarke, Alison; Fields, Hannah; Ferrari, Luca; Ferrari, Franco; McCarthy, Colin L; Sanchez, Amber P; Vitiello, Antonella; Lane, Thomas A; Bejar, Rafael.

Cytotherapy ; 23(3): 236-241, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33279399

8.

In vitro induction of neoantigen-specific T cells in myelodysplastic syndrome, a disease with low mutational burden.

Ferrari, Valentina; Tarke, Alison; Fields, Hannah; Ferrari, Luca; Conley, Trevor; Ferrari, Franco; Kosaloglu-Yalçin, Zeynep; Sette, Alessandro; Peters, Bjoern; McCarthy, Colin L; Bashey, Asad; Tzachanis, Dimitrios; Ball, Edward D; Tanaka, Tiffany N; Bejar, Rafael; Lane, Thomas A; Vitiello, Antonella.

Cytotherapy ; 23(4): 320-328, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33262074

9.

Newly revised 2023 MDS response criteria.

Bejar, Rafael.

Blood ; 141(17): 2035-2036, 2023 04 27.

Artigo em Inglês | MEDLINE | ID: mdl-37103953

10.

Advances in Personalized Therapeutic Approaches in Myelodysplastic Syndromes.

Bejar, Rafael.

J Natl Compr Canc Netw ; 17(11.5): 1444-1447, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31766023

11.

Leveraging premalignant biology for immune-based cancer prevention.

Spira, Avrum; Disis, Mary L; Schiller, John T; Vilar, Eduardo; Rebbeck, Timothy R; Bejar, Rafael; Ideker, Trey; Arts, Janine; Yurgelun, Matthew B; Mesirov, Jill P; Rao, Anjana; Garber, Judy; Jaffee, Elizabeth M; Lippman, Scott M.

Proc Natl Acad Sci U S A ; 113(39): 10750-8, 2016 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-27638202

12.

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.

Qiu, Jinsong; Zhou, Bing; Thol, Felicitas; Zhou, Yu; Chen, Liang; Shao, Changwei; DeBoever, Christopher; Hou, Jiayi; Li, Hairi; Chaturvedi, Anuhar; Ganser, Arnold; Bejar, Rafael; Zhang, Dong-Er; Fu, Xiang-Dong; Heuser, Michael.

RNA ; 22(10): 1535-49, 2016 10.

Artigo em Inglês | MEDLINE | ID: mdl-27492256

13.

Implications of molecular genetic diversity in myelodysplastic syndromes.

Bejar, Rafael.

Curr Opin Hematol ; 24(2): 73-78, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-27875374

14.

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.

Steensma, David P; Bejar, Rafael; Jaiswal, Siddhartha; Lindsley, R Coleman; Sekeres, Mikkael A; Hasserjian, Robert P; Ebert, Benjamin L.

Blood ; 126(1): 9-16, 2015 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-25931582

15.

MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance.

Kwok, Brian; Hall, Jeff M; Witte, John S; Xu, Yin; Reddy, Prashanti; Lin, Keming; Flamholz, Rachel; Dabbas, Bashar; Yung, Aine; Al-Hafidh, Jenan; Balmert, Emily; Vaupel, Christine; El Hader, Carlos; McGinniss, Matthew J; Nahas, Shareef A; Kines, Julie; Bejar, Rafael.

Blood ; 126(21): 2355-61, 2015 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-26429975

16.

Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

Greenberg, Peter L; Stone, Richard M; Al-Kali, Aref; Barta, Stefan K; Bejar, Rafael; Bennett, John M; Carraway, Hetty; De Castro, Carlos M; Deeg, H Joachim; DeZern, Amy E; Fathi, Amir T; Frankfurt, Olga; Gaensler, Karin; Garcia-Manero, Guillermo; Griffiths, Elizabeth A; Head, David; Horsfall, Ruth; Johnson, Robert A; Juckett, Mark; Klimek, Virginia M; Komrokji, Rami; Kujawski, Lisa A; Maness, Lori J; O'Donnell, Margaret R; Pollyea, Daniel A; Shami, Paul J; Stein, Brady L; Walker, Alison R; Westervelt, Peter; Zeidan, Amer; Shead, Dorothy A; Smith, Courtney.

J Natl Compr Canc Netw ; 15(1): 60-87, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-28040720

17.

Recent developments in myelodysplastic syndromes.

Bejar, Rafael; Steensma, David P.

Blood ; 124(18): 2793-803, 2014 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-25237199

18.

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.

Bejar, Rafael; Lord, Allegra; Stevenson, Kristen; Bar-Natan, Michal; Pérez-Ladaga, Albert; Zaneveld, Jacques; Wang, Hui; Caughey, Bennett; Stojanov, Petar; Getz, Gad; Garcia-Manero, Guillermo; Kantarjian, Hagop; Chen, Rui; Stone, Richard M; Neuberg, Donna; Steensma, David P; Ebert, Benjamin L.

Blood ; 124(17): 2705-12, 2014 Oct 23.

Artigo em Inglês | MEDLINE | ID: mdl-25224413

19.

Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study.

Steensma, David P; Abedi, Medrdad; Bejar, Rafael; Cogle, Christopher R; Foucar, Kathryn; Garcia-Manero, Guillermo; George, Tracy I; Grinblatt, David; Komrokji, Rami; Ma, Xiaomei; Maciejewski, Jaroslaw; Pollyea, Daniel A; Savona, Michael R; Scott, Bart; Sekeres, Mikkael A; Thompson, Michael A; Swern, Arlene S; Nifenecker, Melissa; Sugrue, Mary M; Erba, Harry.

BMC Cancer ; 16: 652, 2016 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-27538433

20.

Splicing Factor Mutations in Cancer.

Bejar, Rafael.

Adv Exp Med Biol ; 907: 215-28, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27256388

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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.

Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.

SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.

Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies.

MDS overlap disorders and diagnostic boundaries.

Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation.

Adoptive transfer of neoantigen-specific T-cell therapy is feasible in older patients with higher-risk myelodysplastic syndrome.

In vitro induction of neoantigen-specific T cells in myelodysplastic syndrome, a disease with low mutational burden.

Newly revised 2023 MDS response criteria.

Advances in Personalized Therapeutic Approaches in Myelodysplastic Syndromes.

Leveraging premalignant biology for immune-based cancer prevention.

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.

Implications of molecular genetic diversity in myelodysplastic syndromes.

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.

MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance.

Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

Recent developments in myelodysplastic syndromes.

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.

Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study.

Splicing Factor Mutations in Cancer.