RESUMO
The co-occurrence of microcephaly and Legg-Calvè-Perthes disease (LCPD) in members of the same family has been previously recorded only in two Hungarian brothers. To study the clinical and radiological phenotype in a (second) family with LCPD and microcephaly, clinical, X-ray and MRI follow-up study of two Albanian siblings aged 8 and 11 years, were made. Both siblings had primary microcephaly, seizures and mild-to-moderate mental retardation. At head imaging the boy was found to have skull asymmetry, partial lack of frontal lobe development and partial agenesis of corpus callosum and the girl had a complex brain malformation consisting in thickening of the fronto-temporal cortex, colpocephaly, increased curvature of the Sylvian fissure, elevated tentorium with mild hypoplasia of the cerebellar vermis and dilated cisterna magna. In addition, the brother had ADHD and the sister minor eye anomalies mainly consisting in epicanthic folds and pale bilateral (temporal) optic disk. We recorded (and documented for the first time by brain MRI) a second family with familial co-occurrence of LCPD and microcephaly and the first occurrence of complex brain anomalies in the context of a small head circumference. The present report could encourage the observation of similar cases.
Assuntos
Doença de Legg-Calve-Perthes/complicações , Doença de Legg-Calve-Perthes/diagnóstico , Microcefalia/complicações , Microcefalia/diagnóstico , Irmãos , Criança , Feminino , Humanos , MasculinoRESUMO
Central venous catheters are important in the care for prematurely born children in the neonatal intensive care unit. The purpose of this pictorial essay is to illustrate correct positioning, malpositioning and possible complications of such devices.
Assuntos
Cateterismo Cardíaco/efeitos adversos , Cateterismo Venoso Central/efeitos adversos , Recém-Nascido Prematuro , Radiografia Torácica , Cateterismo Cardíaco/instrumentação , Cateterismo Venoso Central/instrumentação , Meios de Contraste , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , Iopamidol , Masculino , PoliuretanosRESUMO
Autoptic samples of human bones (from 8 weeks of gestation to 12 years of age) and a second group of serial, skeletal x-rays (required for pathologies not related to bone dysplasia in children from 4 months to 17 years of age) provided the material for the analysis of the physes normal growth mechanism presented in this review. Before the appearance of the ossification centers epiphyseal growth rests exclusively on chondrocytes proliferation (interstitial growth), without any detectable differentiated cellular organization. When endochondral ossification starts a defined spatial disposition of chondrocytes and a corresponding organization of the intercellular matrix is set up, so that it is possible to identify a growth vector corresponding to the columns of piled chondrocytes with direction from hypertrophic toward the proliferative cell layers. The complexity of the tubular bones growth process is well represented by the spatial arrangement of the growth vectors. In the late epiphyseal growth another mechanism is active in addition to endochondral ossification, namely, articular cartilage interstitial growth and subchondral remodelling. The knowledge of the normal mode of organization of the physis and its temporal sequence can help to better understand of the deviaton from the normal development of metaphyseal and epiphyseal dysplasias.
Assuntos
Desenvolvimento Ósseo/fisiologia , Adolescente , Osso e Ossos/embriologia , Criança , Pré-Escolar , Condrócitos/citologia , Condrogênese/fisiologia , Epífises/crescimento & desenvolvimento , Desenvolvimento Fetal/fisiologia , Humanos , Lactente , Recém-Nascido , Modelos Anatômicos , Osteogênese/fisiologia , Valores de ReferênciaRESUMO
In children < 2 years of age, cutaneous involvement is the most frequent presentation of Langerhans cell histiocytosis (LCH). Cutaneous LCH can be localized or associated with dissemination and organ dysfunction. The clinical course is variable, ranging from spontaneous regression to a fatal outcome. We describe a female newborn presenting with congenital cutaneous lesions who rapidly developed pulmonary infiltrates and multiple osteolytic lesions. Skin biopsy showed a dermal infiltrate of medium to large cells morphologically and phenotypically consistent with LCH. The clinical course was rapidly fatal in spite of chemotherapy. No strict correlation between morphology and prognosis has been documented in LCH, but, in our case, distinct morphological and immunohistochemical features (CD56 expression and no E-Cadherin expression) may have contributed to an aggressive clinical course.
Assuntos
Antígeno CD56 , Caderinas , Histiocitose de Células de Langerhans/patologia , Forma Celular , Evolução Fatal , Feminino , Histiocitose de Células de Langerhans/congênito , Humanos , Recém-Nascido , Fenótipo , PrognósticoRESUMO
Systemic air embolism in neonates, either premature or full term, necessitating mechanical ventilation is a devastating and usually fatal condition. We describe three cases of this complication, two in mechanically assisted preterm babies, and one in a full-term dysmorphic patient. Causes and possible management are described.
Assuntos
Embolia Aérea/etiologia , Terapia Intensiva Neonatal/métodos , Respiração Artificial/efeitos adversos , Embolia Aérea/diagnóstico , Evolução Fatal , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro , MasculinoAssuntos
Clavícula/diagnóstico por imagem , Clavícula/lesões , Luxação Congênita de Quadril/diagnóstico por imagem , Luxação Congênita de Quadril/etiologia , Complicações do Trabalho de Parto/diagnóstico por imagem , Articulação Esternoclavicular/diagnóstico por imagem , Articulação Esternoclavicular/lesões , Feminino , Humanos , Recém-Nascido , Masculino , Gravidez , RadiografiaRESUMO
We present a child with irregular ossification of tubular bone epiphyses, short bones, and spine. The radiographic evolution of bones undergoing endochondral ossification was followed from the age of 1 year 9 months to 6 years. The unusual features demonstrated in this child made classification difficult: pseudoachondroplasia was excluded because no mutations of the COMP gene were found. Considering the evolution of the radiographic appearances, the most likely diagnosis would seem to be an unusual form of spondyloepiphyseal dysplasia, mimicking some aspects of multiple epiphyseal dysplasia. Endochondral ossification was diffusely altered with a mixture of epiphyseal ossification delay associated with acceleration and early fusion. This case was a unique presentation within the family, suggesting a mutation in the affected child.
Assuntos
Ossos do Carpo/diagnóstico por imagem , Ossificação Heterotópica/diagnóstico por imagem , Osteocondrodisplasias/diagnóstico por imagem , Coluna Vertebral/diagnóstico por imagem , Ossos do Carpo/anormalidades , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Osteocondrodisplasias/congênito , Radiografia , Coluna Vertebral/anormalidadesRESUMO
We report the case of a child affected by acute myeloid leukaemia who was treated with allogeneic haematopoietic stem cell transplantation and developed cervicothoracic spinal osteomyelitis due to Aspergillus flavus. The diagnosis was difficult on a clinical basis, but made possible by conventional radiography and MRI.
Assuntos
Aspergilose/complicações , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Osteomielite/microbiologia , Doenças da Coluna Vertebral/microbiologia , Aspergilose/tratamento farmacológico , Aspergilose/cirurgia , Aspergillus flavus/isolamento & purificação , Lavagem Broncoalveolar , Diagnóstico Diferencial , Evolução Fatal , Febre/etiologia , Humanos , Hidrocefalia/etiologia , Lactente , Leucemia Mieloide Aguda/cirurgia , Imageamento por Ressonância Magnética , Masculino , Osteomielite/tratamento farmacológico , Osteomielite/cirurgia , Radiografia , Doenças Raras , Recidiva , Doenças da Coluna Vertebral/tratamento farmacológico , Doenças da Coluna Vertebral/cirurgia , Coluna Vertebral/diagnóstico por imagem , Coluna Vertebral/patologiaRESUMO
The radiographic follow-up of a patient with Proteus syndrome is presented. Review of radiographs obtained at 3 years 10 months, 10 years, and 17 years 8 months indicated that the rate of growth in length of the oversized tubular bones of the hands was similar to that of the normal bones of the same hand. This observation supports the view that the primary lesion occurs in the early embryonic period, when the limb bud mesenchyme cells condense and cartilage differentiates producing oversized cartilage anlages, rather than being a defect of bone cell-mediated apposition and modelling processes of bone. Additional radiographs of the pelvis and spine were obtained at age 4 years 10 months and head CT at 8 years 10 months. This pathogenetic mechanism fits well with the hypothesis of somatic mosaicism, which is at present the most credible explanation for the aetiology of Proteus syndrome. Other skeletal malformations recognized as typical of the syndrome can be interpreted as secondary adaptations to the altered mechanical conditions induced by overgrowth of bones.
Assuntos
Síndrome de Proteu/diagnóstico por imagem , Adolescente , Humanos , Masculino , RadiografiaRESUMO
A skeletal dysplasia with previously unreported features is presented. Its evolution was characterized by growth abnormalities of bones without involvement of other organs. Advanced bone age, increased stature and irregular epiphyseal ossification with stippling of the main long bones were documented. Physeal overgrowth was massive in the left proximal humerus and femur. Furthermore, the hip joint appeared fused with an abundant mass of pathological calcific tissue extending from the femur to the ilium. Pathological epiphyses were characterized by anarchic cartilaginous proliferation with multiple ossification centres, while lamellar bone apposition and remodelling were normal. The observed bone changes were different from those in any previously reported syndrome, metabolic defect or bone dysplasia. However, they clearly indicated a defect of endochondral ossification with some resemblance to phenotypes observed in dysplasia epiphysealis hemimelica.
Assuntos
Anormalidades Múltiplas/classificação , Anormalidades Múltiplas/diagnóstico por imagem , Doenças do Desenvolvimento Ósseo/classificação , Doenças do Desenvolvimento Ósseo/diagnóstico por imagem , Criança , Pré-Escolar , Humanos , Lactente , Masculino , Radiografia , SíndromeRESUMO
We describe a woman and her daughter affected by brachydactyly type C. The unusual feature in the child included the striking 'angel-shaped' appearance of the proximal phalanges of the index and middle fingers of one hand, whereas more typical triangular epiphyses with elongation of their radial side were present at the same location in the opposite hand. It is suggested that this peculiar phalangeal configuration occurs as a transitory event in early or mid childhood in phalanges that are marked by severe ossification delay, which is most prominent at the level of the primary ossification centre.
Assuntos
Dedos/anormalidades , Deformidades Congênitas da Mão/genética , Adulto , Doenças do Desenvolvimento Ósseo/congênito , Epífises/anormalidades , Feminino , Seguimentos , Humanos , Recém-Nascido , Metacarpo/anormalidades , Polegar/anormalidadesRESUMO
Urethral polyps are a rare finding in children, particularly in the very young. They are suspected by the presence of various clinical signs such as obstruction, voiding dysfunction and haematuria. There is an association with other urinary tract congenital anomalies. They are usually benign fibro-epithelial lesions with no tendency to recur and are treated by surgical ablation, fulguration or laser therapy. We report a 1-month-old boy with an antenatally diagnosed left ectopic pelvic kidney, postnatal urinary tract infection and no clinical signs of obstruction. Voiding cystourethrography to exclude vesico-ureteric reflux showed a trabeculated bladder and a mobile filling defect in the posterior urethra. Owing to its large size, cystotomy was necessary to remove the polyp successfully.
Assuntos
Cistos/diagnóstico por imagem , Doenças Uretrais/diagnóstico por imagem , Humanos , Lactente , Rim/anormalidades , Masculino , Radiografia , Bexiga Urinária/diagnóstico por imagem , Infecções Urinárias/diagnósticoRESUMO
A case of acute appendicitis in a premature baby in whom diagnosis was suggested on plain films of the abdomen is presented. In this baby air in a hollow viscus suspected of being an enlarged appendix was the clue to diagnosis. The diagnostic dilemma of this rare and life-threatening condition in premature babies and newborns is underlined. The relevance of different imaging modalities and of different findings in this age group is discussed. Awareness of this rare condition and possible differential diagnosis in newborns and premature babies is stressed.
Assuntos
Apendicite/congênito , Recém-Nascido Prematuro , Doença Aguda , Apendicite/diagnóstico por imagem , Apêndice/diagnóstico por imagem , Apêndice/patologia , Diagnóstico Diferencial , Feminino , Humanos , Recém-Nascido , Perfuração Intestinal/congênito , Perfuração Intestinal/diagnóstico por imagem , Intensificação de Imagem RadiográficaRESUMO
Jejunal intussusception in a Chinese 10-year-old boy affected by the blue rubber bleb nevus syndrome is presented and discussed. The syndrome is rare, sporadically found with possible dominant inheritance, and due to a gene mutation mapped on the short arm of chromosome 9. It presents with distinctive cutaneous and gastrointestinal malformations together with possible other organ involvement. Gastrointestinal malformations tend to bleed and lead to anaemia. Infrequent complications of the gastrointestinal malformations are volvulus, intestinal infarction and intussusception. The age of the patient and the jejunal intussusception precipitated by a vascular malformation containing calcifications (which were also found in different gut segments) make this case remarkable.
Assuntos
Diagnóstico por Imagem , Intussuscepção/diagnóstico , Intussuscepção/etiologia , Doenças do Jejuno/diagnóstico , Doenças do Jejuno/etiologia , Nevo Azul/complicações , Neoplasias Cutâneas/complicações , Criança , Humanos , Masculino , SíndromeRESUMO
Stratton and Parker [1989] described a 17-month-old boy with the previously unreported combination of growth hormone (GH) deficiency, Wormian bones, mild developmental delay, brachycamptodactyly, heart defects, kidney hypoplasia, imperforate anus, bilateral cryptorchidism, and facial anomalies. A similar case was later reported by Gabrielli et al. [1994], who suggested the existence of a "Stratton-Parker syndrome." Here, we describe a boy with isolated GH deficiency, body asymmetry, and brachycamptodactyly. At birth, complete anorectal agenesis and cryptorchidism were detected, which required surgical treatment. Radiographic examination showed the presence of bilateral proximal radioulnar subluxation and Kirner anomaly. Brain MRI showed asymmetry of the posterior horns of the lateral ventricles and enlarged cisterna magna. Psychomotor development had been mildly delayed during the first years of life. Due to the unique association of GH deficiency with intestinal, genital, and limbs abnormalities, we believe that our patient may represent a further case of Stratton-Parker syndrome. All patients reported, till date, are sporadic males born to healthy nonconsanguineous parents. X-linked recessive inheritance is a possibility to consider.
Assuntos
Canal Anal/anormalidades , Hormônio do Crescimento/deficiência , Deformidades da Mão/genética , Reto/anormalidades , Anormalidades Múltiplas , Adolescente , Criptorquidismo/genética , Deficiências do Desenvolvimento , Humanos , Hipopituitarismo , Masculino , Fenótipo , SíndromeRESUMO
We report a child with a de novo interstitial deletion, 46,XY, int del(9)(9q22.31-q31.2). Cytogenetic and molecular analysis defined the boundaries of the lost region, of paternal origin, from D9S1796 to D9S938. The clinical picture included macrocephaly, frontal bossing, bilateral epicanthus, down-slanted palpebral fissures, low-set ears, hypoplastic nostrils, micrognathia, scoliosis, right single palmar crease, small nails, slender fingers, bilaterally flexed 5th finger, delayed bone age, abnormal metacarpophalangeal pattern (MCPP) profile and sole pits. No major malformation was recorded. The deleted region includes, among others, the PTCH and ROR2 genes. Mutations of the former cause the nevoid basal cell carcinoma syndrome (NBCCS) while mutations in the ROR2 gene have been found both in Robinow syndrome and in brachydactyly type 1B (BDB1). As the patient shows some clinical manifestation of both syndromes, we conclude that phenotypic changes related to haploinsufficiency of PTCH and ROR2 are recognisable in our patient even at a young age and in the presence of the more complex phenotype due to the deletion's large size. Thus the efforts to identify the genes included in a deletion are worthy as they may result in better care of the patient as, in this case, monitoring the possible development of tumours associated with NBCCS.
Assuntos
Anormalidades Múltiplas/genética , Síndrome do Nevo Basocelular/genética , Deleção Cromossômica , Cromossomos Humanos Par 9 , Dedos/anormalidades , Deformidades Congênitas dos Membros/genética , Pré-Escolar , Fácies , Humanos , Masculino , Linhagem , SíndromeRESUMO
OBJECTIVE: To investigate the rate of radiographic progression and identify prognostic factors of radiographic progression, radiographic damage, and physical disability in juvenile idiopathic arthritis (JIA). METHODS: Ninety-four JIA patients with a median disease duration of 1.1 years were followed up prospectively for a median of 4.5 years. Bilateral wrist radiographs were obtained at baseline, at 1 year, and at the last followup visit. Radiographic damage was assessed by the carpal length (Poznanski score), and physical disability by the Childhood Health Assessment Questionnaire (C-HAQ). Yearly radiographic progression, the Poznanski score at the final visit, and the C-HAQ score at the final visit were used as outcome measures. Baseline parameters included demographic, clinical, laboratory, and radiographic data. RESULTS: The mean +/- SD Poznanski score was -1.2 +/- 1.3 at baseline, -1.7 +/- 1.8 at the 1-year visit, and -1.9 +/- 2.2 at the final visit (P < 0.0001). Radiographic progression was greater during the first year (mean +/- SD -0.5 +/- 1.1) than between the 1-year visit and the final visit (-0.2 +/- 1.3). The mean yearly radiographic progression during the entire study period was -0.1 +/- 0.4. Logistic regression analysis revealed that radiographic progression during the first year was the only baseline parameter that was predictive of all 3 study outcomes. The final Poznanski score was also predicted by the baseline Poznanski score, whereas female sex was protective against radiographic progression. CONCLUSION: We identified the prognostic factors for poorer outcome in polyarticular-course JIA. The changes in the early Poznanski score can be used to predict long-term joint damage and physical disability.