RESUMO
MOTIVATION: The evaluation of chemicals for their carcinogenic hazard requires the analysis of a wide range of data and the characterization of these results relative to the key characteristics of carcinogens. The workflow used historically requires many manual steps that are labor-intensive and can introduce errors, bias and inconsistencies. RESULTS: The automation of parts of the evaluation workflow using the kc-hits software has led to significant improvements in process efficiency, as well as more consistent and comprehensive results. AVAILABILITY AND IMPLEMENTATION: https://gitlab.com/i1650/kc-hits.git. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Assuntos
Carcinógenos , Software , Automação , Carcinógenos/toxicidade , Fluxo de TrabalhoAssuntos
Cobalto , Tungstênio , Ligas/toxicidade , Antimônio/toxicidade , Cobalto/toxicidade , Humanos , Tungstênio/toxicidadeAssuntos
Neoplasias da Mama/diagnóstico , Autoexame de Mama , Detecção Precoce de Câncer , Mamografia , Guias de Prática Clínica como Assunto , Adulto , Comitês Consultivos , Idoso , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/genética , Neoplasias da Mama/mortalidade , Análise Custo-Benefício , Detecção Precoce de Câncer/métodos , Feminino , Humanos , Imageamento Tridimensional , Pessoa de Meia-Idade , UltrassonografiaAssuntos
Benzeno/toxicidade , Carcinogênese/induzido quimicamente , Carcinógenos Ambientais/toxicidade , Neoplasias Hematológicas/induzido quimicamente , Leucemia Mieloide Aguda/induzido quimicamente , Animais , Benzeno/administração & dosagem , Testes de Carcinogenicidade , Consenso , Modelos Animais de Doenças , Feminino , França , Neoplasias Hematológicas/epidemiologia , Neoplasias Hematológicas/fisiopatologia , Humanos , Incidência , Internacionalidade , Leucemia Mieloide Aguda/fisiopatologia , Masculino , Exposição Ocupacional/efeitos adversos , Distribuição Aleatória , Ratos , Medição de Risco , Taxa de SobrevidaAssuntos
Carcinógenos Ambientais/efeitos adversos , Molibdênio/efeitos adversos , Neoplasias/induzido quimicamente , Exposição Ocupacional/efeitos adversos , Saúde Ocupacional , Óxidos/efeitos adversos , Compostos de Estanho/efeitos adversos , Soldagem , Animais , Carcinógenos Ambientais/classificação , Humanos , Molibdênio/classificação , Neoplasias/diagnóstico , Neoplasias/epidemiologia , Óxidos/classificação , Medição de Risco , Compostos de Estanho/classificaçãoRESUMO
BACKGROUND: Through extensive review of the published literature, two independent expert panels convened by the International Agency for Research on Cancer (IARC) Monographs Programme have classified crystalline silica as carcinogenic to humans while amorphous silica was not classifiable as to its carcinogenicity in humans. The panel remarked that crystalline silica in the form of quartz or cristobalite dust causes lung cancer in humans. OBJECTIVES: We discuss the literature and rationale used to support the IARC evaluations of silica. METHODS: A critical review, with a focus on lung tumors, was conducted of the pertinent literature on the carcinogenic effects of crystalline silica in humans and experimental animals as well as supportive mechanistic evidence. RESULTS: The strongest supportive evidence comes from pooled and meta-analyses that employed quantitative exposure assessment, focused on silicotics, accounted for potential confounding and demonstrated exposure-response trends. Consistency of the effect was observed despite some heterogeneity between individual studies. Tumor site concordance was observed with rodents and further supported by mechanistic data. CONCLUSIONS: Several million workers worldwide are exposed to crystalline silica. Silicosis and lung cancer in these workers are completely preventable diseases. The IARC evaluations are critical to supporting public health interventions to protect persons at high-risk.