Detalhe da pesquisa
1.
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Nature
; 609(7928): 829-834, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36104565
2.
Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity and function in the Wnt signaling pathway.
J Biol Chem
; : 107407, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38796065
3.
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Proc Natl Acad Sci U S A
; 118(46)2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34750265
4.
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.
Angew Chem Int Ed Engl
; 62(11): e202217532, 2023 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625768
5.
Conformational plasticity of the ULK3 kinase domain.
Biochem J
; 478(14): 2811-2823, 2021 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34190988
6.
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
Int J Mol Sci
; 23(2)2022 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35054947
7.
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light.
Angew Chem Int Ed Engl
; 60(37): 20178-20183, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081840
8.
Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
Int J Cancer
; 147(10): 2847-2861, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32599645
9.
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Angew Chem Int Ed Engl
; 58(4): 1062-1066, 2019 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30569600
10.
Binding Kinetics Survey of the Drugged Kinome.
J Am Chem Soc
; 140(46): 15774-15782, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362749
11.
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
J Med Chem
; 67(1): 674-690, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38126712
12.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
ACS Chem Biol
; 19(2): 266-279, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38291964
13.
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.
J Med Chem
; 67(5): 3813-3842, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38422480
14.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
bioRxiv
; 2024 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38405908
15.
Death by a Thousand Cuts â" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology.
bioRxiv
; 2023 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711619
16.
Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting.
Elife
; 122023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38047771
17.
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.
ACS Med Chem Lett
; 14(6): 833-840, 2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37312836
18.
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.
J Med Chem
; 66(1): 837-854, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36516476
19.
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.
ACS Chem Biol
; 18(4): 822-836, 2023 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36944371
20.
Resistance to kinase inhibition through shortened target engagement.
Mol Cell Oncol
; 9(1): 2029999, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35252553