Detalhe da pesquisa
1.
Helicase-primase inhibitor pritelivir for HSV-2 infection.
N Engl J Med
; 370(3): 201-10, 2014 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24428466
2.
No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.
J Infect Dis
; 214(2): 258-64, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056950
3.
Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
JAMA
; 316(23): 2495-2503, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27997653
4.
Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
Antimicrob Agents Chemother
; 58(7): 3843-52, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752278
5.
Mass Balance and Metabolite Profile after Single and Multiple Oral Doses of Pritelivir in Healthy Subjects.
Clin Pharmacol Drug Dev
; 13(4): 389-403, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38189209
6.
Evaluation of the Clinical Drug-Drug Interaction Potential of Pritelivir on Transporters and CYP450 Enzymes Using a Cocktail Approach.
Clin Pharmacol Drug Dev
; 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38752475
7.
First-in-Human, Single- and Multiple-Ascending-Dose, Food-Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase-Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects.
Clin Pharmacol Drug Dev
; 12(7): 749-760, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36860173
8.
Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections.
J Med Chem
; 65(20): 13614-13628, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202389
9.
Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor.
J Antimicrob Chemother
; 65(7): 1347-52, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453068
10.
Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export and interaction with cellular receptors.
J Virol
; 83(1): 396-407, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18945775
11.
Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity.
Antiviral Res
; 80(1): 81-5, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18539344
12.
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro.
Antiviral Res
; 158: 135-142, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30031759
13.
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.
Antiviral Res
; 149: 1-6, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29113740
14.
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.
J Med Chem
; 60(7): 3154-3164, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28272885
15.
HSV antivirals - current and future treatment options.
Curr Opin Virol
; 18: 9-13, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26897058
16.
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.
Sci Transl Med
; 8(324): 324ra15, 2016 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26843190
17.
Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.
Antiviral Res
; 100(2): 297-9, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24021190
18.
Effects of therapy using a helicase-primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant.
Antiviral Res
; 87(1): 67-73, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20420855