Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 42
Filtrar
1.
NMR Biomed ; 35(5): e4656, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-34962689

RESUMO

In this study, the performance of an integrated body-imaging array for 7 T with 32 radiofrequency (RF) channels under consideration of local specific absorption rate (SAR), tissue temperature, and thermal dose limits was evaluated and the imaging performance was compared with a clinical 3 T body coil. Thirty-two transmit elements were placed in three rings between the bore liner and RF shield of the gradient coil. Slice-selective RF pulse optimizations for B1 shimming and spokes were performed for differently oriented slices in the body under consideration of realistic constraints for power and local SAR. To improve the B1+ homogeneity, safety assessments based on temperature and thermal dose were performed to possibly allow for higher input power for the pulse optimization than permissible with SAR limits. The results showed that using two spokes, the 7 T array outperformed the 3 T birdcage in all the considered regions of interest. However, a significantly higher SAR or lower duty cycle at 7 T is necessary in some cases to achieve similar B1+ homogeneity as at 3 T. The homogeneity in up to 50 cm-long coronal slices can particularly benefit from the high RF shim performance provided by the 32 RF channels. The thermal dose approach increases the allowable input power and the corresponding local SAR, in one example up to 100 W/kg, without limiting the exposure time necessary for an MR examination. In conclusion, the integrated antenna array at 7 T enables a clinical workflow for body imaging and comparable imaging performance to a conventional 3 T clinical body coil.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Imageamento por Ressonância Magnética/métodos , Imagens de Fantasmas , Temperatura
2.
NMR Biomed ; 34(7): e4515, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33942938

RESUMO

The aim of the current study was to investigate the performance of integrated RF transmit arrays with high channel count consisting of meander microstrip antennas for body imaging at 7 T and to optimize the position and number of transmit elements. RF simulations using multiring antenna arrays placed behind the bore liner were performed for realistic exposure conditions for body imaging. Simulations were performed for arrays with as few as eight elements and for arrays with high channel counts of up to 48 elements. The B1+ field was evaluated regarding the degrees of freedom for RF shimming in the abdomen. Worst-case specific absorption rate (SARwc ), SAR overestimation in the matrix compression, the number of virtual observation points (VOPs) and SAR efficiency were evaluated. Constrained RF shimming was performed in differently oriented regions of interest in the body, and the deviation from a target B1+ field was evaluated. Results show that integrated multiring arrays are able to generate homogeneous B1+ field distributions for large FOVs, especially for coronal/sagittal slices, and thus enable body imaging at 7 T with a clinical workflow; however, a low duty cycle or a high SAR is required to achieve homogeneous B1+ distributions and to exploit the full potential. In conclusion, integrated arrays allow for high element counts that have high degrees of freedom for the pulse optimization but also produce high SARwc , which reduces the SAR accuracy in the VOP compression for low-SAR protocols, leading to a potential reduction in array performance. Smaller SAR overestimations can increase SAR accuracy, but lead to a high number of VOPs, which increases the computational cost for VOP evaluation and makes online SAR monitoring or pulse optimization challenging. Arrays with interleaved rings showed the best results in the study.


Assuntos
Imageamento por Ressonância Magnética/instrumentação , Ondas de Rádio , Simulação por Computador , Humanos , Masculino , Modelos Biológicos
3.
J Magn Reson Imaging ; 53(2): 333-346, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32830900

RESUMO

Magnetic resonance imaging and spectroscopy (MRI/MRS) at 7T represents an exciting advance in MR technology, with intriguing possibilities to enhance image spatial, spectral, and contrast resolution. To ensure the safe use of this technology while still harnessing its potential, clinical staff and researchers need to be cognizant of some safety concerns arising from the increased magnetic field strength and higher Larmor frequency. The higher static magnetic fields give rise to enhanced transient bioeffects and an increased risk of adverse incidents related to electrically conductive implants. Many technical challenges remain and the continuing rapid pace of development of 7T MRI/MRS is likely to present further challenges to ensuring safety of this technology in the years ahead. The recent regulatory clearance for clinical diagnostic imaging at 7T will likely increase the installed base of 7T systems, particularly in hospital environments with little prior ultrahigh-field MR experience. Informed risk/benefit analyses will be required, particularly where implant manufacturer-published 7T safety guidelines for implants are unavailable. On behalf of the International Society for Magnetic Resonance in Medicine, the aim of this article is to provide a reference document to assist institutions developing local institutional policies and procedures that are specific to the safe operation of 7T MRI/MRS. Details of current 7T technology and the physics underpinning its functionality are reviewed, with the aim of supporting efforts to expand the use of 7T MRI/MRS in both research and clinical environments. Current gaps in knowledge are also identified, where additional research and development are required. Level of Evidence 5 Technical Efficacy 2 J. MAGN. RESON. IMAGING 2021;53:333-346.


Assuntos
Campos Magnéticos , Imageamento por Ressonância Magnética , Humanos , Imageamento por Ressonância Magnética/efeitos adversos , Espectroscopia de Ressonância Magnética , Física
4.
MAGMA ; 34(1): 153-163, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32964299

RESUMO

OBJECTIVE: In local SAR compression algorithms, the overestimation is generally not linearly dependent on actual local SAR. This can lead to large relative overestimation at low actual SAR values, unnecessarily constraining transmit array performance. METHOD: Two strategies are proposed to reduce maximum relative overestimation for a given number of VOPs. The first strategy uses an overestimation matrix that roughly approximates actual local SAR; the second strategy uses a small set of pre-calculated VOPs as the overestimation term for the compression. RESULT: Comparison with a previous method shows that for a given maximum relative overestimation the number of VOPs can be reduced by around 20% at the cost of a higher absolute overestimation at high actual local SAR values. CONCLUSION: The proposed strategies outperform a previously published strategy and can improve the SAR compression where maximum relative overestimation constrains the performance of parallel transmission.


Assuntos
Compressão de Dados , Algoritmos , Simulação por Computador , Imageamento por Ressonância Magnética , Imagens de Fantasmas
5.
Magn Reson Med ; 82(5): 1859-1875, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31199013

RESUMO

PURPOSE: To evaluate radiofrequency (RF) induced tissue heating around aneurysm clips during a 7T head MR examination and to determine the decoupling distance between multiple implanted clips. METHODS: A total of 120 RF exposure scenarios of clinical relevance were studied using specific absorption rate and temperature simulations. Variations between scenarios included 2 clips (18.8 and 51.5 mm length), 2 MR-operating modes, 2 head models, and 3 thermoregulation models. Furthermore, a conservative approach was developed to allow for safe scans of patients with aneurysm clips even if detailed information on the implanted clip is unknown. A dedicated simulation-based approach was applied to determine the decoupling distance between multiple implanted clips. RESULTS: For all 60 clinical scenarios with the 18.8-mm-long clip, the absolute tissue temperature remained below regulatory limits. For 15 of 60 scenarios with the 51.5-mm-long clip, limits were slightly exceeded (less than 1°C). The conservative approach led to a maximum time-averaged input power of the RF coil of 3.3W. The corresponding B1+ is 1.32 µT. A decoupling distance of 35 mm allows the aneurysm clips to be treated as uncoupled from one other. CONCLUSION: Safe scanning conditions with respect to RF-induced heating can be applied for single or decoupled aneurysm clips in a 7T ultra-high field MRI setting. Multiple aneurysm clips separated by less than 35 mm need further investigations.


Assuntos
Imageamento por Ressonância Magnética/instrumentação , Instrumentos Cirúrgicos/efeitos adversos , Segurança de Equipamentos , Temperatura Alta , Humanos , Aneurisma Intracraniano/cirurgia , Imagens de Fantasmas , Desenho de Prótese , Ondas de Rádio
6.
Magn Reson Med ; 82(2): 796-810, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30924181

RESUMO

PURPOSE: A 16-channel receive (16Rx) radiofrequency (RF) array for 7T ultra-high field body MR imaging is presented. The coil is evaluated in conjunction with a 16-channel transmit/receive (16TxRx) coil and additionally with a 32-channel transmit/receive (32TxRx) remote body coil for RF transmit and serving as receive references. METHODS: The 16Rx array consists of 16 octagonal overlapping loops connected to custom-built detuning boards with preamplifiers. Performance metrics like noise correlation, g-factors, and signal-to-noise ratio gain were compared between 4 different RF coil configurations. In vivo body imaging was performed in volunteers using radiofrequency shimming, time interleaved acquisition of modes (TIAMO), and 2D spatially selective excitation using parallel transmit (pTx) in the spine. RESULTS: Lower g-factors were obtained when using the 16Rx coil in addition to the 16TxRx array coil configuration versus the 16TxRx array alone. Distinct signal-to-noise ratio gain using the 16Rx coil could be demonstrated in the spine region both for a comparison with the 16TxRx coil (>50% gain) in vivo and the 32TxRx coil (>240% gain) in a phantom. The 16Rx coil was successfully applied to improve anatomical imaging in the abdomen and 2D spatially selective excitation in the spine of volunteers. CONCLUSION: The novel 16-channel Rx-array as an add-on to multichannel TxRx RF coil configurations provides increased signal-to-noise ratio, lower g-factors, and thus improves 7T ultra-high field body MR imaging.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Coluna Vertebral/diagnóstico por imagem , Adulto , Desenho de Equipamento , Humanos , Masculino , Imagens de Fantasmas
7.
Neuroimage ; 168: 33-58, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-28336426

RESUMO

At ultra-high fields, the assessment of radiofrequency (RF) safety presents several new challenges compared to low-field systems. Multi-channel RF transmit coils in combination with parallel transmit techniques produce time-dependent and spatially varying power loss densities in the tissue. Further, in ultra-high-field systems, localized field effects can be more pronounced due to a transition from the quasi stationary to the electromagnetic field regime. Consequently, local information on the RF field is required for reliable RF safety assessment as well as for monitoring of RF exposure during MR examinations. Numerical RF and thermal simulations for realistic exposure scenarios with anatomical body models are currently the only practical way to obtain the requisite local information on magnetic and electric field distributions as well as tissue temperature. In this article, safety regulations and the fundamental characteristics of RF field distributions in ultra-high-field systems are reviewed. Numerical methods for computation of RF fields as well as typical requirements for the analysis of realistic multi-channel RF exposure scenarios including anatomical body models are highlighted. In recent years, computation of the local tissue temperature has become of increasing interest, since a more accurate safety assessment is expected because temperature is directly related to tissue damage. Regarding thermal simulation, bio-heat transfer models and approaches for taking into account the physiological response of the human body to RF exposure are discussed. In addition, suitable methods are presented to validate calculated RF and thermal results with measurements. Finally, the concept of generalized simulation-based specific absorption rate (SAR) matrix models is discussed. These models can be incorporated into local SAR monitoring in multi-channel MR systems and allow the design of RF pulses under constraints for local SAR.


Assuntos
Absorção de Radiação , Radiação Eletromagnética , Temperatura Alta , Imageamento por Ressonância Magnética/normas , Modelos Anatômicos , Modelos Teóricos , Ondas de Rádio , Segurança/normas , Absorção de Radiação/fisiologia , Adulto , Feminino , Temperatura Alta/efeitos adversos , Humanos , Imageamento por Ressonância Magnética/efeitos adversos , Masculino , Ondas de Rádio/efeitos adversos
8.
Magn Reson Med ; 79(5): 2652-2664, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-28994132

RESUMO

PURPOSE: Current methods for mitigation of transmit field B1+ inhomogeneities at ultrahigh field (UHF) MRI by multi-channel radiofrequency (RF) shimming rely on accurate B1+ mapping. This can be time consuming when many RF channels have to be mapped for in vivo body MRI, where the B1 maps should ideally be acquired within a single breath-hold. Therefore, a new B1+ mapping technique (B1TIAMO) is proposed. METHODS: The performance of this technique is validated against an established method (DREAM) in phantom measurements for a cylindrical head phantom with an 8-channel transmit/receive (Tx/Rx) array. Furthermore, measurements for a 32-channel Tx/Rx remote array are conducted in a large body phantom and the |B1+| map reliability is validated against simulations of the transmit RF field distribution. Finally, in vivo results of this new mapping technique for human abdomen are presented. RESULTS: For the head phantom (8-channel Tx/Rx coil), the single |B1+| comparison between B1 TIAMO, the direct DREAM measurements, and simulation data showed good agreement with 10-19% difference. For the large body phantom (32-channel Tx/Rx coil), B1TIAMO matched the RF field simulations well. CONCLUSION: The results demonstrate the potential to acquire 32 accurate single-channel B1+ maps for large field-of-view body imaging within only a single breath-hold of 16 s at 7T UHF MRI. Magn Reson Med 79:2652-2664, 2018. © 2017 International Society for Magnetic Resonance in Medicine.


Assuntos
Interpretação de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Desenho de Equipamento , Cabeça/diagnóstico por imagem , Humanos , Rim/diagnóstico por imagem , Masculino , Imagens de Fantasmas , Reprodutibilidade dos Testes , Imagem Corporal Total
9.
Magn Reson Med ; 79(2): 1116-1126, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28394080

RESUMO

PURPOSE: In this work, 22 configurations for remote radiofrequency (RF) coil arrays consisting of different transmit element designs for 7 Tesla (T) ultrahigh-field MRI are compared by numerical simulations. METHODS: Investigated transmit RF element types are rectangular loops, micro striplines, micro striplines with meanders, 250-mm shielded dipoles with meanders, and lambda over two dipoles with and without shield. These elements are combined in four different configurations of circumferential RF body arrays with four or eight transmit elements each. Comparisons included coupling behavior, degrees of freedom offered by the individual transmit patterns, and metrics like power and specific absorption rate efficiency. RESULTS: Coupling between neighboring RF elements is elevated (up to -7 dB) for all arrays with eight elements, whereas it is below -25 dB for arrays with only four elements. The cumulative sum of singular values points out highest degrees of freedom for the central transversal, reduced values in the central coronal, and minimum values in the sagittal slice. Concerning power and SAR efficiency, eight lambda over two dipoles are most advantageous. CONCLUSIONS: Among the investigated remote arrays and parameters, a combination of eight dipoles appears to be most favorable for potential use in 7T body MRI. Magn Reson Med 79:1116-1126, 2018. © 2017 International Society for Magnetic Resonance in Medicine.


Assuntos
Imageamento por Ressonância Magnética/instrumentação , Simulação por Computador , Desenho de Equipamento , Humanos , Ondas de Rádio
10.
Magn Reson Med ; 79(1): 568-581, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28266079

RESUMO

PURPOSE: To examine radiofrequency-induced tissue heating around intracranial aneurysm clips during a 7 Tesla (T) head MR examination. METHODS: Radiofrequency (RF), temperature simulations, and RF measurements were employed to investigate the effects of polarization and clip length on the electric field (E-field) and temperature. Heating in body models was studied using both a conservative approach and realistic exposure scenarios. RESULTS: Worst-case orientation was found for clips aligned parallel to the E-field polarization. Absolute tissue temperature remained below International Electrotechnical Commission regulatory limits for 44 of 50 clinical scenarios. No significant effect on heating was determined for clip lengths below 18.8 mm, and worst-case heating was found for clip length 51.5 mm. The conservative approach led to a maximum permissible E-field of 72 V/m corresponding to B1+ of 1.2 µT, and an accepted power of 4.6 W for the considered RF head coil instead of 38.5 W without clip. CONCLUSION: Safe scanning conditions with respect to RF-induced heating can be applied depending on the information about the clip gained during screening interviews. However, force and torque measurements in the MR system shall be conducted to give a final statement on the MR safety of aneurysm clips at 7T. Magn Reson Med 79:568-581, 2018. © 2017 International Society for Magnetic Resonance in Medicine.


Assuntos
Hipertermia Induzida , Aneurisma Intracraniano/diagnóstico por imagem , Imageamento por Ressonância Magnética , Instrumentos Cirúrgicos , Simulação por Computador , Temperatura Alta , Humanos , Lactente , Imagens de Fantasmas , Ondas de Rádio , Estresse Mecânico , Torque
11.
Magn Reson Med ; 78(2): 805-811, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-27604749

RESUMO

PURPOSE: To calculate local specific absorption rate (SAR) correctly, both the amplitude and phase of the signal in each transmit channel have to be known. In this work, we propose a method to derive a conservative upper bound for the local SAR, with a reasonable safety margin without knowledge of the transmit phases of the channels. METHODS: The proposed method uses virtual observation points (VOPs). Correction factors are calculated for each set of VOPs that prevent underestimation of local SAR when the VOPs are applied with the correct amplitudes but fixed phases. RESULTS: The proposed method proved to be superior to the worst-case calculation based on the maximum eigenvalue of the VOPs. The mean overestimation for six coil setups could be reduced, whereas no underestimation of the maximum local SAR occurred. In the best investigated case, the overestimation could be reduced from a factor of 3.3 to a factor of 1.7. CONCLUSION: The upper bound for the local SAR calculated with the proposed method allows a fast estimation of the local SAR based on power measurements in the transmit channels and facilitates SAR monitoring in systems that do not have the capability to monitor transmit phases. Magn Reson Med 78:805-811, 2017. © 2016 International Society for Magnetic Resonance in Medicine.


Assuntos
Imageamento por Ressonância Magnética , Modelos Teóricos , Absorção de Radiação , Razão Sinal-Ruído
12.
Magn Reson Med ; 75(3): 933-45, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25943445

RESUMO

PURPOSE: To assess the feasibility of prostate (1)H MR spectroscopic imaging (MRSI) using low-power spectral-spatial (SPSP) pulses at 7T, exploiting accurate spectral selection and spatial selectivity simultaneously. METHODS: A double spin-echo sequence was equipped with SPSP refocusing pulses with a spectral selectivity of 1 ppm. Three-dimensional prostate (1)H-MRSI at 7T was performed with the SPSP-MRSI sequence using an 8-channel transmit array coil and an endorectal receive coil in three patients with prostate cancer and in one healthy subject. No additional water or lipid suppression pulses were used. RESULTS: Prostate (1)H-MRSI could be obtained well within specific absorption rate (SAR) limits in a clinically feasible time (10 min). Next to the common citrate signals, the prostate spectra exhibited high spermine signals concealing creatine and sometimes also choline. Residual lipid signals were observed at the edges of the prostate because of limitations in spectral and spatial selectivity. CONCLUSION: It is possible to perform prostate (1)H-MRSI at 7T with a SPSP-MRSI sequence while using separate transmit and receive coils. This low-SAR MRSI concept provides the opportunity to increase spatial resolution of MRSI within reasonable scan times.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Espectroscopia de Ressonância Magnética/métodos , Adulto , Idoso , Aminas/química , Ácido Cítrico/química , Humanos , Masculino , Imagens de Fantasmas , Próstata/química , Próstata/metabolismo , Próstata/fisiologia , Processamento de Sinais Assistido por Computador
13.
MAGMA ; 29(3): 389-98, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27026243

RESUMO

OBJECTIVE: This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. MATERIALS AND METHODS: The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T1-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T2-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. RESULTS: Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. CONCLUSION: Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI.


Assuntos
Placas Ósseas , Encéfalo/diagnóstico por imagem , Craniotomia/métodos , Imageamento por Ressonância Magnética , Adulto , Artefatos , Encéfalo/patologia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/cirurgia , Desenho de Equipamento , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Neurocirurgia , Período Pós-Operatório , Período Pré-Operatório , Estudos Prospectivos , Crânio/diagnóstico por imagem , Titânio/química , Adulto Jovem
14.
Magn Reson Med ; 73(3): 909-20, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24677408

RESUMO

PURPOSE: Optimization of phosphorus ((31) P) MR spectroscopic imaging (MRSI) of the human prostate at 7 T by the evaluation of T1 relaxation times and the Nuclear Overhauser Effect (NOE) of phosphorus-containing metabolites. METHODS: Twelve patients with prostate cancer and one healthy volunteer were scanned on a 7 T whole-body system using a (31) P endorectal coil combined with an eight-channel (1) H body array coil. T1 relaxation times were measured using progressive saturation in a two-dimensional localization sequence. (31) P MRSI was performed twice: once without NOE and once with NOE using low-power continuous wave (1) H irradiation to determine NOE enhancements. RESULTS: T1 relaxation times of (31) P metabolites in the human prostate at 7 T varied between 3.0 and 8.3 s. Positive but variable NOE enhancements were measured for most metabolites. Remarkably, the (31) P MR spectra showed two peaks in chemical shift range of inorganic phosphate. CONCLUSION: Knowledge of T1 relaxation times and NOE enhancements enables protocol optimization for (31) P MRSI of the prostate at 7 T. With a strongly reduced (31) P flip angle (≤ 45°), a (31) P MRSI dataset with optimal signal-to-noise ratio per unit time can be obtained within 15 minutes. The NOE enhancement can improve fitting accuracy, but its variability requires further investigation.


Assuntos
Algoritmos , Imageamento Tridimensional/métodos , Espectroscopia de Ressonância Magnética/métodos , Imagem Molecular/métodos , Compostos de Fósforo/metabolismo , Neoplasias da Próstata/metabolismo , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Isótopos de Fósforo/farmacocinética , Próstata , Neoplasias da Próstata/patologia , Compostos Radiofarmacêuticos/farmacocinética , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Distribuição Tecidual
15.
NMR Biomed ; 28(11): 1570-8, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26492089

RESUMO

The design and construction of a dedicated RF coil setup for human brain imaging ((1)H) and spectroscopy ((31)P) at ultra-high magnetic field strength (7 T) is presented. The setup is optimized for signal handling at the resonance frequencies for (1)H (297.2 MHz) and (31)P (120.3 MHz). It consists of an eight-channel (1)H transmit-receive head coil with multi-transmit capabilities, and an insertable, actively detunable (31)P birdcage (transmit-receive and transmit only), which can be combined with a seven-channel receive-only (31)P array. The setup enables anatomical imaging and (31)P studies without removal of the coil or the patient. By separating transmit and receive channels and by optimized addition of array signals with whitened singular value decomposition we can obtain a sevenfold increase in SNR of (31)P signals in the occipital lobe of the human brain compared with the birdcage alone. These signals can be further enhanced by 30 ± 9% using the nuclear Overhauser effect by B1-shimmed low-power irradiation of water protons. Together, these features enable acquisition of (31)P MRSI at high spatial resolutions (3.0 cm(3) voxel) in the occipital lobe of the human brain in clinically acceptable scan times (~15 min).


Assuntos
Aumento da Imagem/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Lobo Occipital/metabolismo , Compostos de Fósforo/metabolismo , Espectroscopia de Prótons por Ressonância Magnética/instrumentação , Espectroscopia de Prótons por Ressonância Magnética/métodos , Adulto , Desenho de Equipamento , Análise de Falha de Equipamento , Humanos , Magnetismo/instrumentação , Masculino , Imagem Molecular/instrumentação , Lobo Occipital/anatomia & histologia , Fósforo/farmacocinética , Ondas de Rádio , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Distribuição Tecidual , Transdutores
16.
MAGMA ; 28(6): 577-90, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26410044

RESUMO

OBJECT: Over the last decade, the number of clinical MRI studies at 7 T has increased dramatically. Since only limited information about the safety of implants/tattoos is available at 7 T, many centers either conservatively exclude all subjects with implants/tattoos or have started to perform dedicated tests for selected implants. This work presents our experience in imaging volunteers with implants/tattoos at 7 T over the last seven and a half years. MATERIALS AND METHODS: 1796 questionnaires were analyzed retrospectively to identify subjects with implants/tattoos imaged at 7 T. For a total of 230 subjects, the type of local transmit/receive RF coil used for examination, imaging sequences, acquisition time, and the type of implants/tattoos and their location with respect to the field of view were documented. These subjects had undergone examination after careful consideration by an internal safety panel consisting of three experts in MR safety and physics. RESULTS: None of the subjects reported sensations of heat or force before, during, or after the examination. None expressed any discomfort related to implants/tattoos. Artifacts were reported in 52% of subjects with dental implants; all artifacts were restricted to the mouth area and did not affect image quality in the brain parenchyma. CONCLUSION: Our initial experience at 7 T indicates that a strict rejection of subjects with tattoos and/or implants is not justified. Imaging can be conditionally performed in carefully selected subjects after collection of substantial safety information and evaluation of the detailed exposure scenario (RF coil/type and position of implant). Among the assessed subjects with tattoos, no side effects from the exposure to 7 T MRI were reported.


Assuntos
Imageamento por Ressonância Magnética/métodos , Próteses e Implantes , Tatuagem , Artefatos , Contraindicações , Segurança de Equipamentos , Feminino , Voluntários Saudáveis , Humanos , Masculino , Segurança do Paciente , Ondas de Rádio , Estudos Retrospectivos , Inquéritos e Questionários
17.
Magn Reson Med ; 71(5): 1711-9, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-23798333

RESUMO

PURPOSE: To demonstrate that high quality T2 -weighted (T2w) turbo spin-echo (TSE) imaging of the complete prostate can be achieved routinely and within safety limits at 7 T, using an external transceive body array coil only. METHODS: Nine healthy volunteers and 12 prostate cancer patients were scanned on a 7 T whole-body system. Preparation consisted of B0 and radiofrequency shimming and localized flip angle calibration. T1 and T2 relaxation times were measured and used to define the T2w-TSE protocol. T2w imaging was performed using a TSE sequence (pulse repetition time/echo time 3000-3640/71 ms) with prolonged excitation and refocusing pulses to reduce specific absorption rate. RESULTS: High quality T2w TSE imaging was performed in less than 2 min in all subjects. Tumors of patients with gold-standard tumor localization (MR-guided biopsy or prostatectomy) were well visualized on 7 T imaging (n = 3). The number of consecutive slices achievable within a 10-g averaged specific absorption rate limit of 10 W/kg was ≥28 in all subjects, sufficient for full prostate coverage with 3-mm slices in at least one direction. CONCLUSION: High quality T2w TSE prostate imaging can be performed routinely and within specific absorption rate limits at 7 T with an external transceive body array.


Assuntos
Algoritmos , Imagem Ecoplanar/métodos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Próstata/patologia , Neoplasias da Próstata/patologia , Adulto , Idoso , Estudos de Viabilidade , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Marcadores de Spin , Adulto Jovem
18.
Magn Reson Med ; 70(1): 290-4, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22886695

RESUMO

In magnetic resonance imaging, there has been a constant drive to higher static magnetic field strengths (B0) to achieve a higher signal-to-noise ratio and new or enhanced contrasts. In today's high-field systems, severe problems regarding the homogeneity of the transmission field are encountered. Recently, an acquisition scheme called Time-Interleaved Acquisition of Modes has been proposed to tackle the inhomogeneity problems in high-field magnetic resonance imaging. The basic premise is to excite two (or more) different B1(+) modes using static radiofrequency shimming in an interleaved acquisition, where the complementary radiofrequency patterns of the two modes can be exploited to improve overall signal homogeneity. In its usual implementation, a multichannel transmit system is required. In this work, the goal is to present a simple and inexpensive hardware setup which makes it possible to use time-interleaved acquisition of modes on any single-channel transmit system while making use of the vendor-provided single-channel radiofrequency safety system. To demonstrate the efficacy of this setup, spin echo images from the pelvis are acquired at 7 T exhibiting no complete signal dropouts.


Assuntos
Artefatos , Aumento da Imagem/instrumentação , Interpretação de Imagem Assistida por Computador/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Pelve/anatomia & histologia , Transdutores , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
20.
Eur Radiol ; 23(9): 2364-73, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23645332

RESUMO

OBJECTIVES: The aim of this study was to investigate the feasibility of 7-T contrast-enhanced MR imaging of the female pelvis. METHODS: Ten healthy female volunteers were examined on a 7-T whole-body MR system utilising a custom-built eight-channel transmit/receive radiofrequency body coil. The examination protocol included (1) T1-weighted fat-saturated 2D spoiled gradient echo (FLASH), (2) dynamic T1-weighted fat-saturated 3D FLASH, and (3) T2-weighted TSE sequences. For qualitative image analysis pelvic anatomy, uterine zonal anatomy and image impairment due to artefacts was assessed using a five-point scale. For quantitative analysis contrast ratios between the junctional zone and myometrium were obtained for T2-weighted MRI. RESULTS: Two-dimensional FLASH MRI offered the best overall image quality (meancontrast-enhanced 4.9) and highest tissue contrast (meancontrast-enhanced 4.7). T2-weighted TSE imaging provided a moderate to high conspicuity of the uterine zonal anatomy with mean scores ranging from 3.5 for endometrium to 4.65 for myometrium. Overall image impairment was rated strongest for T2-weighted MRI (2.9) and least for 2D FLASH MRI (mean 4.2). CONCLUSION: This study demonstrated the feasibility of 7-T T1-weighted MRI of the female pelvis and current constraints associated with T2-weighted MRI. KEY POINTS: • Dynamic contrast-enhanced female pelvis MR imaging at 7 T is feasible. • Unenhanced T1-weighted MRI offers inherent hyperintense delineation of pelvic arterial vasculature. • Two-dimensional FLASH MRI provided best overall image quality and least artefact impairment.


Assuntos
Imageamento por Ressonância Magnética/métodos , Pelve/patologia , Adulto , Artefatos , Gráficos por Computador , Meios de Contraste/farmacologia , Desenho de Equipamento , Feminino , Voluntários Saudáveis , Humanos , Processamento de Imagem Assistida por Computador , Movimento (Física) , Reprodutibilidade dos Testes , Interface Usuário-Computador
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA