Detalhe da pesquisa
1.
Renal and Multiorgan Safety of 177Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer in the VISION Dosimetry Substudy.
J Nucl Med
; 65(1): 71-78, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38050121
2.
Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives.
Bioorg Med Chem Lett
; 23(6): 1846-52, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23395656
3.
Pharmacokinetics and Safety of Multiple-Dose Alpelisib in Participants with Moderate or Severe Hepatic Impairment: A Phase 1, Open-Label, Parallel Group Study.
J Cancer
; 14(9): 1571-1578, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37325049
4.
A Phase 1b/2 Study of Alpelisib in Combination with Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Target Oncol
; 18(6): 853-868, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875771
5.
Physiologically Based Biopharmaceutics Modeling to Demonstrate Virtual Bioequivalence and Bioequivalence Safe-space for Ribociclib which has Permeation Rate-controlled Absorption.
J Pharm Sci
; 111(1): 274-284, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34678270
6.
Alpelisib in combination with everolimus ± exemestane in solid tumours: Phase Ib randomised, open-label, multicentre study.
Eur J Cancer
; 151: 49-62, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33964572
7.
Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection.
AAPS J
; 22(6): 134, 2020 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33070288
8.
Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer: A Phase 1b Clinical Trial.
JAMA Oncol
; 5(2): e184475, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30543347
9.
Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study.
J Clin Oncol
; 36(13): 1291-1299, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29401002
10.
Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b.
Methods Enzymol
; 406: 1-11, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16472645
11.
Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers.
Cancer Chemother Pharmacol
; 76(4): 751-60, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26254025
12.
Crystal structure of Rnd3/RhoE: functional implications.
FEBS Lett
; 525(1-3): 100-4, 2002 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-12163169
13.
Comparative functional analysis of the Rac GTPases.
FEBS Lett
; 555(3): 556-60, 2003 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-14675773
14.
Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate.
Chembiochem
; 9(7): 1024-8, 2008 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18351684
15.
BetaQ114N and betaT110V mutations reveal a critically important role of the substrate alpha-carboxylate site in the reaction specificity of tryptophan synthase.
Biochemistry
; 46(49): 14100-16, 2007 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18004874
16.
Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding.
Biochemistry
; 46(26): 7728-39, 2007 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17559231
17.
Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands.
Biochemistry
; 46(26): 7740-53, 2007 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17559232
18.
Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex.
Biochemistry
; 46(26): 7713-27, 2007 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17559195
19.
Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.
J Biol Chem
; 279(51): 53419-26, 2004 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15475352
20.
Inactivation and activation of Ras by the neurotrophin receptor p75.
Eur J Neurosci
; 20(9): 2321-35, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15525274