Detalhe da pesquisa
1.
DNA glycosylases provide antiviral defence in prokaryotes.
Nature
; 629(8011): 410-416, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38632404
2.
Bacterial cGAS senses a viral RNA to initiate immunity.
Nature
; 623(7989): 1001-1008, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37968393
3.
A naturally inspired antibiotic to target multidrug-resistant pathogens.
Nature
; 601(7894): 606-611, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34987225
4.
Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity.
Nature
; 625(7993): E3, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38052939
5.
Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules.
Nature
; 556(7699): 135, 2018 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29620727
6.
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics.
Angew Chem Int Ed Engl
; 63(17): e202317187, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38231130
7.
Commensal bacteria make GPCR ligands that mimic human signalling molecules.
Nature
; 549(7670): 48-53, 2017 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28854168
8.
Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics.
Bioorg Med Chem Lett
; 57: 128484, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34861348
9.
Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against Mycobacterium tuberculosis.
J Nat Prod
; 84(4): 1056-1066, 2021 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33621083
10.
Metagenome-Guided Analogue Synthesis Yields Improved Gram-Negative-Active Albicidin- and Cystobactamid-Type Antibiotics.
Angew Chem Int Ed Engl
; 60(41): 22172-22177, 2021 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355488
11.
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.
J Am Chem Soc
; 142(33): 14158-14168, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32697091
12.
Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.
Proc Natl Acad Sci U S A
; 114(44): 11615-11620, 2017 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29078342
13.
Total Synthesis of Malacidin A by ß-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment.
Angew Chem Int Ed Engl
; 59(45): 19868-19872, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32725837
14.
Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome.
J Am Chem Soc
; 141(40): 15737-15741, 2019 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31545899
15.
Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.
J Am Chem Soc
; 141(9): 3910-3919, 2019 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30735616
16.
Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.
Proc Natl Acad Sci U S A
; 113(51): 14811-14816, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27911822
17.
Discovery of MRSA active antibiotics using primary sequence from the human microbiome.
Nat Chem Biol
; 12(12): 1004-1006, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748750
18.
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.
Proc Natl Acad Sci U S A
; 112(29): 8953-8, 2015 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26150486
19.
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.
Proc Natl Acad Sci U S A
; 112(35): E4825-34, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26283367
20.
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.
Proc Natl Acad Sci U S A
; 112(14): 4221-6, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25831524