Simulations of high permittivity materials for 7 T neuroimaging and evaluation of a new barium titanate-based dielectric.

High permittivity "dielectric pads" have been shown to increase image quality at high magnetic fields in regions of low radiofrequency transmit efficiency. This article presents a series of electromagnetic simulations to determine the effects of pad size and geometry, relative permittivity value, as well as thickness on the transmit radiofrequency fields for neuroimaging at 7 T. For a 5-mm thick pad, there is virtually no effect on the transmit field for relative permittivity values lower than ∼90. Significant improvements are found for values between 90 and ∼180. If the relative permittivity is increased above ∼180 then areas of very low transmit efficiency are produced. For a 1-cm thick pad, the corresponding numbers are ∼60 and ∼120, respectively. Based upon the findings, a new material (barium titanate, relative permittivity ∼150) is used to produce thin (∼5 mm) dielectric pads which can easily be placed within a standard receive head array. Experimental measurements of transmit sensitivities, as well as acquisition of T(2) - and T 2*-weighted images show the promise of this approach.

Increasing signal homogeneity and image quality in abdominal imaging at 3 T with very high permittivity materials.

The appearance of severe signal drop-outs in abdominal imaging at 3 T arises primarily from areas of very low B1+ transmit field in the body, and is problematic in both obese as well as very thin subjects. In this study, we show how thin patient-friendly pads containing new high permittivity materials can be designed and optimized, and when placed around the subject increase substantially the B1+ uniformity and the image quality. Results from nine healthy volunteers show that inclusion of these dielectric pads results in statistically significant decreases in the coefficient of variance of the B1+ field, with stronger and more uniform fields being produced. In addition there are statistically significant decreases in time-averaged power required for scanning. These differences are present in both quadrature-mode operation (coefficient of variance decrease, P<0.0001, mean 25.4±10%: power decrease, P=0.005, mean 14±14%) and also for the RF-shimmed case (coefficient of variance decrease, P=0.01, mean 16±13%: power decrease, P=0.005, mean 22±11%) of a dual-transmit system.

High-Permittivity Pad Design for Dielectric Shimming in Magnetic Resonance Imaging Using Projection-Based Model Reduction and a Nonlinear Optimization Scheme.

Inhomogeneities in the transmit radio frequency magnetic field ( ) reduce the quality of magnetic resonance (MR) images. This quality can be improved by using high-permittivity pads that tailor the fields. The design of an optimal pad is application-specific and not straightforward and would therefore benefit from a systematic optimization approach. In this paper, we propose such a method to efficiently design dielectric pads. To this end, a projection-based model order reduction technique is used that significantly decreases the dimension of the design problem. Subsequently, the resulting reduced-order model is incorporated in an optimization method in which a desired field in a region of interest can be set. The method is validated by designing a pad for imaging the cerebellum at 7 T. The optimal pad that is found is used in an MR measurement to demonstrate its effectiveness in improving the image quality.

Practical improvements in the design of high permittivity pads for dielectric shimming in neuroimaging at 7T.

Improvements are proposed for practical design and use of high permittivity materials in high field neuroimaging in three different areas: (i) a simple formula to predict the permittivity of tri-component aqueous-based perovskite suspensions with relative permittivities between 110 and 300, (ii) characterization of addition of a hydroxyethyl-cellulose gelling agent to improve the long-term stability and material properties of "dielectric pads", and (iii) investigation of the integration of, for example, headphones into the dielectric pads to increase patient comfort within tightly-fitting receive coil arrays.

Visualization of human inner ear anatomy with high-resolution MR imaging at 7T: initial clinical assessment.

BACKGROUND AND PURPOSE: In many centers, MR imaging of the inner ear and auditory pathway performed on 1.5T or 3T systems is part of the preoperative work-up of cochlear implants. We investigated the applicability of clinical inner ear MR imaging at 7T and compared the visibility of inner ear structures and nerves within the internal auditory canal with images acquired at 3T. MATERIALS AND METHODS: Thirteen patients with sensorineural hearing loss eligible for cochlear implantation underwent examinations on 3T and 7T scanners. Two experienced head and neck radiologists evaluated the 52 inner ear datasets. Twenty-four anatomic structures of the inner ear and 1 overall score for image quality were assessed by using a 4-point grading scale for the degree of visibility. RESULTS: The visibility of 11 of the 24 anatomic structures was rated higher on the 7T images. There was no significant difference in the visibility of 13 anatomic structures and the overall quality rating. A higher incidence of artifacts was observed in the 7T images. CONCLUSIONS: The gain in SNR at 7T yielded a more detailed visualization of many anatomic structures, especially delicate ones, despite the challenges accompanying MR imaging at a high magnetic field.

Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma.

OBJECTIVE: This study was performed to evaluate the effect of prolonged treatment with the dopamine agonist quinagolide on serum gonadotropin and alpha-subunit concentrations and tumor volume in patients with clinically non-functioning pituitary adenomas (CNPA). DESIGN: Ten patients with CNPA were treated with quinagolide (0.3 mg daily). The median duration of treatment was 57 months (range 36-93 months). Blood samples for measurement of serum gonadotropin and alpha-subunit concentrations were drawn before treatment, after 5 days, and at each outpatient visit. Computerized tomography or magnetic resonance imaging of the pituitary region and Goldmann perimetry were done before and at regular intervals during treatment. RESULTS: A significant decrease of serum FSH, LH or alpha-subunit concentrations was found in nine patients. The levels remained low during the entire treatment period. In two out of three patients with pre-existing visual field defects a slight improvement was shown during the first months of treatment, but eventually deterioration occurred in all three patients. A fourth patient developed unilateral ophthalmoplegia during treatment. During the first year tumor volume decreased in three patients, but in two of them regrowth occurred after a few months. In six patients progressive tumor growth occurred despite sustained suppression of gonadotropin or alpha-subunit levels. CONCLUSIONS: Long-term treatment of patients with CNPA with high doses of the dopamine agonist quinagolide could not prevent progressive increase in tumor size in most patients. It remains unproven whether quinagolide retards CNPA growth. Additional studies are needed to investigate whether subgroups of patients, e.g. those with positive dopamine receptor scintigraphy or those with marked hypersecretion of intact gonadotropins or subunits, will respond more favorably to treatment with dopamine agonists.