RESUMO
Probability of treatment-free remission (TFR) in CML patients with additional chromosomal abnormalities (ACA) in the Philadelphia-positive clone or variant Philadelphia translocations (ACA/Var-Ph group, blue panel), in those with no cytogenetic abnormality other than the classical Philadelphia translocation (c-Ph group, green panel) and in the subgroups of CML patients with high-risk ACA (HR-ACA, yellow panel) and Var-Ph (red panel).
Assuntos
Leucemia Mielogênica Crônica BCR-ABL Positiva , Cromossomo Filadélfia , Indução de Remissão , Translocação Genética , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/genética , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Aberrações Cromossômicas , Idoso , AdolescenteAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Transtornos da Coagulação Sanguínea , Cromossomos Humanos Par 16 , Cromossomos Humanos Par 8 , Leucemia Mieloide Aguda , Translocação Genética , Adulto , Transtornos da Coagulação Sanguínea/tratamento farmacológico , Transtornos da Coagulação Sanguínea/genética , Transtornos da Coagulação Sanguínea/metabolismo , Transtornos da Coagulação Sanguínea/patologia , Cromossomos Humanos Par 16/genética , Cromossomos Humanos Par 16/metabolismo , Cromossomos Humanos Par 8/genética , Cromossomos Humanos Par 8/metabolismo , Citarabina/administração & dosagem , Daunorrubicina/administração & dosagem , Dexametasona/administração & dosagem , Gemtuzumab/administração & dosagem , Humanos , Leucemia Mieloide Aguda/tratamento farmacológico , Leucemia Mieloide Aguda/genética , Leucemia Mieloide Aguda/metabolismo , Leucemia Mieloide Aguda/patologia , Masculino , Tretinoína/administração & dosagemAssuntos
Autoantígenos/genética , Proteínas de Ciclo Celular/genética , Síndrome Hipereosinofílica/genética , Leucemia Mielomonocítica Crônica/genética , Proteínas de Fusão Oncogênica/genética , Receptor beta de Fator de Crescimento Derivado de Plaquetas/genética , Antineoplásicos/uso terapêutico , Autoantígenos/química , Proteínas de Ciclo Celular/química , Cromossomos Humanos Par 5/genética , Cromossomos Humanos Par 8/genética , Humanos , Síndrome Hipereosinofílica/tratamento farmacológico , Mesilato de Imatinib/uso terapêutico , Leucemia Mielomonocítica Crônica/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Mutagênese Insercional , Proteínas de Fusão Oncogênica/química , Inibidores de Proteínas Quinases/uso terapêutico , RNA Neoplásico/genética , Receptor beta de Fator de Crescimento Derivado de Plaquetas/químicaRESUMO
African Americans experience a disproportionately greater burden of chronic kidney disease (CKD) Stage 5 than Caucasians and other minority groups. Precursors to CKD may also be components of metabolic syndrome. This study identified modifiable risk factors for CKD in an African-American metabolic syndrome cohort and compared results by gender. Both men and women (52%) had blood pressure values of 130/80 or higher, impaired fasting glucose levels of 100 to 125 mg/dL (25.5%), and body mass index greater than 25 (98.9%). There was no significant difference between genders. Appropriate clinical management of these factors may prevent or delay the onset of CKD.
Assuntos
Negro ou Afro-Americano , Falência Renal Crônica , Síndrome Metabólica , Medição de Risco/organização & administração , Negro ou Afro-Americano/etnologia , Negro ou Afro-Americano/estatística & dados numéricos , Distribuição de Qui-Quadrado , Estudos Transversais , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/etnologia , Feminino , Georgia/epidemiologia , Humanos , Hiperlipidemias/complicações , Hiperlipidemias/etnologia , Hipertensão/complicações , Hipertensão/etnologia , Falência Renal Crônica/etnologia , Falência Renal Crônica/etiologia , Falência Renal Crônica/prevenção & controle , Estilo de Vida/etnologia , Masculino , Síndrome Metabólica/etnologia , Síndrome Metabólica/etiologia , Síndrome Metabólica/prevenção & controle , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/etnologia , Comportamento de Redução do Risco , Distribuição por Sexo , Fumar/efeitos adversos , Fumar/etnologia , Estatísticas não ParamétricasRESUMO
The Eastside Illicit Drinkers Group for Education has been supportive of research dedicated to establishing the effectiveness of Managed Alcohol Programs since its inception. Dedicated funding for MAPs in Vancouver, British Columbia is contingent on the research demonstrating that alcohol-related harms are reduced while participating in a Managed Alcohol Program. The Eastside Illicit Drinkers Group for Education understands the need for evidence-based research but we are critical of how much research is needed before sustainable funding can be established for these innovative programs.
Assuntos
Álcoois , Redução do Dano , Educação em Saúde , Drogas Ilícitas , Canadá , Prática Clínica Baseada em Evidências , HumanosRESUMO
Food security is a challenge facing many African-American low-income communities nationally. Community and university partners have established urban agriculture programs to improve access to high quality affordable fruits and vegetables by growing, distributing, and selling food in urban neighborhoods. While the challenge of food security is within communities of color, few studies have described these urban agriculture programs and documented their impact on the crew members who work in the programs and live in the low-income communities. More information is needed on the program impact for crew and community health promotion. Using a survey and focus group discussion from the crew and staff we describe the program and activities of four Chicago Urban Agriculture programs. We summarized the impact these programs have on crew members' perception of urban agriculture, health habits, community engagement, and community health promotion in low-income African-American neighborhoods.
Assuntos
Agricultura , Abastecimento de Alimentos , Promoção da Saúde/métodos , População Urbana , Adolescente , Adulto , Negro ou Afro-Americano , Chicago , Relações Comunidade-Instituição , Feminino , Grupos Focais , Alimentos , Humanos , Masculino , Avaliação de Programas e Projetos de Saúde , Universidades , Adulto JovemRESUMO
OBJECTIVE: To provide a more comprehensive view than previously available of US physician preparedness for public health emergencies, this study examined physicians' assessments of their preparedness, training, participation in institutional activities, information practices, and experiences with patient education. Four kinds of public health emergencies were considered: natural disasters, major airborne infections, major foodborne illness outbreaks, and chemical, biological, radiological, nuclear, or explosives (CBRNE) incidents. METHODS: Between October 19, 2011, and January 11, 2012, researchers conducted a national poll among 1603 practicing physicians in a range of specialties in hospital and nonhospital settings. RESULTS: More than one-half of physicians felt prepared to handle a natural disaster, a major outbreak of an airborne infection, or a major foodborne illness outbreak, whereas one-third (34%) felt prepared to handle a CBRNE incident. About one-half of physicians (55%) had participated in training or a conference related to emergencies in the past 2 years. Sizable fractions of physicians were unaware of emergency response tools in their care setting. For example, nearly one-half in hospitals (44%) did not know whether their care setting had an emergency response plan, and less than one-quarter had participated in a drill using such a plan in the past 2 years. Less than one-third (31%) of physicians had signed up to receive alerts in the case of future emergencies. One in 10 reported sharing emergency information with patients at least "sometimes." CONCLUSIONS: Significant gaps remain in physician preparedness for public health emergencies, as well as in related training and participation in institutional activities. New efforts, with a focus on possible collaborations between public health institutions and health system leaders combined with effective use of online resources, are needed to bring more physicians on board and to develop relevant and useful key tools. New approaches, including those that rely on different types of care providers, may be needed to enhance patient education regarding emergency preparedness.