Detalhe da pesquisa
1.
An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase.
Chemistry
; 30(8): e202303335, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37971151
2.
Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum.
Arch Biochem Biophys
; 754: 109950, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38430969
3.
Escherichia coli YgiC and YjfC Possess PeptideâSpermidine Ligase Activity.
Biochemistry
; 62(4): 899-911, 2023 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36745518
4.
Discovery of an Ê-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism.
J Biol Chem
; 298(10): 102392, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35988643
5.
Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.
J Am Chem Soc
; 145(16): 9207-9222, 2023 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37042073
6.
The Oxidation of Oxygen and Sulfur-Containing Heterocycles by Cytochrome P450 Enzymes.
Chemistry
; 29(50): e202301371, 2023 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37338048
7.
The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.
Arch Biochem Biophys
; 737: 109554, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36842492
8.
Structure-guided design and synthesis of ATP-competitive N-acyl-substituted sulfamide d-alanine-d-alanine ligase inhibitors.
Bioorg Med Chem
; 96: 117509, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37948922
9.
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.
Biochem J
; 479(13): 1441-1454, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35730699
10.
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes.
J Biol Chem
; 297(3): 101030, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34339734
11.
Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA.
J Biol Chem
; 296: 100773, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33984330
12.
A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.
Proteins
; 90(8): 1509-1520, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247004
13.
Investigating the Active Oxidants Involved in Cytochrome P450 Catalyzed Sulfoxidation Reactions.
Chemistry
; 28(72): e202202428, 2022 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36169207
14.
Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering.
Chemistry
; 28(67): e202201895, 2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36043399
15.
To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme.
Inorg Chem
; 61(1): 236-245, 2022 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910500
16.
TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.
Cell Mol Life Sci
; 78(8): 4035-4052, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33834258
17.
Engineering potassium activation into biosynthetic thiolase.
Biochem J
; 478(15): 3047-3062, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34338286
18.
Mechanisms Governing Precise Protein Biotinylation.
Trends Biochem Sci
; 42(5): 383-394, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268045
19.
d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.
J Biol Chem
; 295(23): 7894-7904, 2020 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32335509
20.
Approaches to Introduce Helical Structure in Cysteine-Containing Peptides with a Bimane Group.
Chembiochem
; 22(17): 2711-2720, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34107164