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1.
J Pediatr Nurs ; 72: e210-e216, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37385940

RESUMO

BACKGROUND AND PURPOSE: This study was designed to determine the perceptions of fathers about child sexual abuse in Turkey using metaphors to facilitate understanding of child sexual abuse. METHODS: The study was conducted as a qualitative study based on metaphor analysis. The data were collected from 164 Turkish fathers in Turkey between August 2022 and September 2022 using a descriptive information form for fathers and a semi-structured interview form exploring fathers' perceptions of child sexual abuse. The semi-structured interview form included metaphor statements like "Child sexual abuse is like....... because .......", and "Child sexual abuse reminds me of the color....... because .......". The data were analyzed using the content analysis technique. The study was reported based on Standards for Reporting Qualitative Research (SRQR). RESULTS: According to the results, 77.4% of the fathers had knowledge about protecting their children from sexual abuse, 40.9% got this information from the internet, and only 11.1% educated their children about sexual abuse. Seventy three percent of the fathers were afraid of confusing their children while educating them. The fathers involved in the study used 20 metaphors related to "child sexual abuse" and "the color evoked by child sexual abuse". The metaphors created by the fathers were analyzed under six categories: "emotions, feeling inadequate, punishment method, abuser, child concept, and uncertainty". CONCLUSION: Based on the results of the study, fathers had common feelings and emphasize the same concepts about child sexual abuse. PRACTICE IMPLICATIONS: Metaphors provide a unique approach to identifying fathers' conceptual images of child sexual abuse.


Assuntos
Abuso Sexual na Infância , Maus-Tratos Infantis , Masculino , Criança , Humanos , Pai/psicologia , Metáfora , Turquia
2.
J Pediatr Nurs ; 69: e105-e113, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36585347

RESUMO

BACKGROUND AND PURPOSE: The study aimed to evaluate the attitudes of parents in the role of a father in Turkey toward child sex education and their sexual communication with their children. METHODS: This descriptive and cross-sectional study was conducted with the fathers of children in the pediatric outpatient clinic at a state hospital between December 30, 2021, and April 15, 2022. The study was reported based on STROBE. The data were collected from 297 fathers using the Descriptive Information Form, the Attitudes Scale Toward Sex education (ASTSE), and the Sexual Communication Scale for Parents(SCSP). RESULTS: Sample statistics demonstrate that 67.7% of the participants did not receive sex education in their childhood, and 57.4% stated that their children received sex education only from their mothers. Higher attitudes toward sexual education were found in the fathers with a university or higher education degree (χ2 = 15.396; p < 0.01), and those giving sex education to their children (χ2 = 18.388;p < 0.001). Higher total scores were obtained on the sexual communication scale by fathers with university and higher education degrees (χ2 = 12.898;p < 0.01) and those who received sex education in their childhood (t = 2.330;p = 0.021). There is a highly significant positive correlation between the mean scores of the role of a parent subscale of the ASTSE and the mean total score of the SCSP (r = 0.81;p < 0.001). CONCLUSIONS: There is a positive correlation between fathers' parental role attitudes toward sex education and their sexual communication with their children. PRACTICE IMPLICATIONS: Supporting fathers' sexual communication with their children can positively affect fathers' attitudes and communication toward sex education.


Assuntos
Pais , Educação Sexual , Criança , Feminino , Humanos , Comunicação , Estudos Transversais , Turquia , Masculino
3.
Chem Biodivers ; 19(7): e202100931, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35674435

RESUMO

The ketene dithioacetal 3 generated from 2-nitroperchlorobutadiene 1 reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene-N,S,S-acetals and S,S,S-acetals 4a-f, 5a-h as heterocyclic dithiolanes. They were separated/purified by chromatographic methods and their exact structure characterization were made clear by spectroscopic methods. These compounds synthesized could act as effective drugs for versatile activity. Evaluation of the antimicrobial effect of the obtained substances determined derivatives 4e and 5h, which have MIC=15.6 µg/mL for the test culture of Mycobacterium luteum bacteria closing to the control drug Vancomycin. The obtained compounds can be proposed as a promising synthetic objects for future molecular design to enhance the antimicrobial action. Ketene dithioacetals 3, 4a, 4b, 4e, 5g (50 mg/kg) exhibited antiseizure effect comparable with reference drug (valproic acid) on the model of pentylenetetrazole-induced convulsions after single oral administration both at 3 h and 24 h. Furthermore, tested dithioacetals possessed prolonged antidepressant activity in forced swim test (FST) considerable decreasing the duration of immobility time compared to reference drug amitriptyline. This is the first study of the investigation of anticonvulsant and antidepressant activities of ketene dithioacetals.


Assuntos
Acetais , Antifúngicos , Acetais/química , Acetais/farmacologia , Antibacterianos/farmacologia , Anticonvulsivantes/farmacologia , Antidepressivos/química , Antidepressivos/farmacologia , Antifúngicos/farmacologia , Etilenos , Cetonas
4.
J Pediatr Nurs ; 67: e224-e233, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35879194

RESUMO

PURPOSE: This study aims to examine in depth the potential child emotional neglect behaviors of nurses working in the COVID-19 service, and their feelings, thoughts, and experiences regarding the causes and effects on their children. DESIGN AND METHODS: The study was designed as a qualitative study based on a descriptive phenomenological approach. A purposeful sample of service providers (N = 22) in the COVID-19 clinics of the region's largest hospital in northeast Turkey in terms of education and patient care were recruited for the study. The data were collected through semi-structured interviews using the individual in-depth face-to-face interview method. The interviews were audio-recorded, transcribed verbatim, and analyzed with Braun and Clarke's thematic analysis method. The research was reported by following Consolidated criteria for reporting qualitative research-COREQ. RESULTS: The findings enabled the identification of four unique themes expressed by the participants: parent-child interaction, social impact, physiological impact, and psychological impact. The first theme consists of adversely affected time nurses spent with their children, decreased physical contact, and communication problems; the second theme includes nurses' and their children's social isolation and social stigma; the third theme includes a change in eating habits and daily activities; the fourth theme includes fear of losing parents and emotional change. CONCLUSIONS AND PRACTICE IMPLICATIONS: To prevent the increased emotional neglect potential due to the COVID-19 pandemic, it is necessary to regulate the working conditions of parents who are nursing professionals and support the parent/child emotionally and psychologically.


Assuntos
COVID-19 , Enfermeiras e Enfermeiros , Humanos , Pandemias , Pesquisa Qualitativa , Pais/psicologia , Relações Pais-Filho
5.
J Pediatr Nurs ; 66: 111-119, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35709634

RESUMO

BACKGROUND AND PURPOSE: Pain experiences in childhood are very likely to be reflected in adulthood. The early evaluation of the concept of pain in children may eventually lead to. better patient outcomes in the future. Therefore, we aimed to culturally and developmentally adapt the Concept of Pain Inventory for Children (COPI) for Turkish children. METHODS: This descriptive, correlational study was conducted with 239 post-operative children aged 8-12 years between June and December 2021. The research adhered to COSMIN guidelines. The data were collected using a descriptive information form and the COPI. Factor analysis, Cronbach's alpha, and item-total score analysis were used for the data analysis. RESULTS: The resulting unidimensional scale consists of 12 items in Turkish. The scale explained 65% of the total variance. The exploratory factor analysis showed that the factor loadings of items ranged from 0.64 to 0.91. The confirmatory factor analysis showed that the factor loadings of items ranged from 0.66 to 0.92. Goodness of fit indexes were found to be as follows: Normed Fit Index >0.90; Incremental Fit Index >0.90; Comparative Fit Index >0.90; and the Root Mean Square Error of Approximation <0.08. The total Cronbach's alpha coefficient of the scale was 0.78 (reliable). CONCLUSIONS: The 12-item Turkish translation of the COPI was deemed valid and reliable in 8-12-year-old children in a post-operative setting. PRACTICE IMPLICATIONS: Evaluation of children's pain concepts during childhood may contribute to the identification of conceptual gaps for pain science education.


Assuntos
Dor , Criança , Humanos , Psicometria , Reprodutibilidade dos Testes , Inquéritos e Questionários , Turquia
6.
J Craniofac Surg ; 31(7): e693-e694, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32569052

RESUMO

Adenoid cystic carcinoma is the most common type of malignancy seen in the lacrimal glands and is generally characterized by invasive malignant appearance with irregular margins and associated bone erosion or destruction. The authors report an unusual patient with a large expansile, well-circumscribed lacrimal adenoid cystic carcinoma with adjacent bone remodeling, radiologically mimicking a benign lesion.


Assuntos
Carcinoma Adenoide Cístico/cirurgia , Neoplasias Oculares/cirurgia , Doenças do Aparelho Lacrimal/cirurgia , Adulto , Remodelação Óssea , Carcinoma Adenoide Cístico/diagnóstico por imagem , Neoplasias Oculares/diagnóstico por imagem , Neoplasias Oculares/patologia , Feminino , Humanos , Doenças do Aparelho Lacrimal/diagnóstico por imagem , Doenças do Aparelho Lacrimal/patologia
7.
J Craniofac Surg ; 30(7): 2280-2284, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31369515

RESUMO

Dural sinuses have critical importance during intracranial approaches. Detailed anatomical knowledge of the dural sinuses is crucial for surgeons to reduce unexpected venous bleeding. The aim of this study was to investigate anatomical relation of sigmoid sinus and tentorium cerebelli according to clinically palpable landmarks and cranial morphometry. The authors evaluated 222 individuals' (94 women, 128 men) 3-dimensional computed tomography angiograms, retrospectively. The authors also studied on 12 mid-sagittal cut dried hemiskulls and 8 formalin fixed cadaver heads hemisected midsagitally. All measurements were completed using Osirix-Lite version 9 software. Craniometrical values were measured to define cranium morphology. Furthermore, level of the sigmoid sinus according to asterion and tentorial angle were evaluated in detail. Our results demonstrated that there were significant differences between parameters and genders, except vertical angle of the tentorium cerebelli. Distance between asterion and sigmoid sinus was statistically different between right and left sides in favor of the left side. This also varied depending on the position of the sigmoid sinus, as well. Only transverse angle between the upper point of external acoustic meatus and asterion demonstrated a significant correlation with age. This study evaluated the detailed 3D anatomy of sigmoid sinus and tentorium cerebelli related with the cranium morphology. Determining to sigmoid sinus anatomy according to clinically palpable landmarks has advantages for setting surgical protocols and reducing to unexpected injuries while surgery to these structures.


Assuntos
Medula Espinal/anatomia & histologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Angiografia , Cadáver , Cefalometria , Cavidades Cranianas/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
8.
J Neuroradiol ; 46(3): 193-198, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-29913178

RESUMO

PURPOSE: To increase the knowledge of central nervous system (CNS) imaging features in deficiency of adenosine deaminase 2 (DADA2) by examining magnetic resonance imaging (MRI) studies of a relatively large number of patients. METHODS: We retrospectively examined neuroimages of 12 patients (7 male, 5 female) diagnosed with DADA2. The mean age of the patients at the time of initial brain MRI was 16.7±10.2 years. Seven patients (58.3%) fulfilled the classification criteria of polyarteritis nodosa. Brain MRI studies were assessed with respect to findings of ischemia, intracranial hemorrhages, focal parenchymal signal abnormalities, cerebral/cerebellar volume loss, and abnormal contrast enhancement. Angiographic studies of 7 patients were evaluated for the signs of vasculitis. RESULTS: The most frequent finding was acute and/or chronic lacunar ischemic lesions in the brainstem and/or deep gray matter (n=9, 75%). Six patients (50%) revealed MRI findings compatible with recurrent ischemic attacks. Small nodular contrast enhancement (n=2, 16.6%), acute putaminal hemorrhage (n=1, 8.3%) and findings compatible with posterior reversible encephalopathy syndrome (n=1, 8.3%) were also detected. Slight-to-moderate diffuse cerebral and/or cerebellar volume loss (n=7, 58.3%), decreased T1 signal of the bone marrow (n=6, 50%) and optic atrophy (n=1, 8.3%) were the other findings on brain MRI. The only abnormal angiographic finding was reduced caliber of the right distal posterior cerebral artery in MRA of a patient (14.6%). CONCLUSION: DADA2 should be included in the differential diagnosis of young patients presenting with ischemic and/or hemorrhagic lesions located in the brainstem and deep gray matter, especially if they have a family history or additional systemic abnormalities.


Assuntos
Adenosina Desaminase/deficiência , Encefalopatias/diagnóstico por imagem , Encefalopatias/enzimologia , Angiografia por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
9.
Pol J Radiol ; 83: e289-e296, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30627249

RESUMO

A variety of conditions may affect the trigeminal nerve. Magnetic resonance imaging is the modality of choice when trigeminal nerve pathology is suspected, and this modality plays an essential role in detecting causes. This review illustrates some of the pathological conditions relevant to the trigeminal nerve in magnetic resonance imaging.

10.
NMR Biomed ; 29(5): 532-44, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26854004

RESUMO

Image quality in non-contrast-enhanced (NCE) angiograms is often limited by scan time constraints. An effective solution is to undersample angiographic acquisitions and to recover vessel images with penalized reconstructions. However, conventional methods leverage penalty terms with uniform spatial weighting, which typically yield insufficient suppression of aliasing interference and suboptimal blood/background contrast. Here we propose a two-stage strategy where a tractographic segmentation is employed to auto-extract vasculature maps from undersampled data. These maps are then used to incur spatially adaptive sparsity penalties on vascular and background regions. In vivo steady-state free precession angiograms were acquired in the hand, lower leg and foot. Compared with regular non-adaptive compressed sensing (CS) reconstructions (CSlow ), the proposed strategy improves blood/background contrast by 71.3 ± 28.9% in the hand (mean ± s.d. across acceleration factors 1-8), 30.6 ± 11.3% in the lower leg and 28.1 ± 7.0% in the foot (signed-rank test, P < 0.05 at each acceleration). The proposed targeted reconstruction can relax trade-offs between image contrast, resolution and scan efficiency without compromising vessel depiction.


Assuntos
Vasos Sanguíneos/anatomia & histologia , Meios de Contraste/química , Interpretação de Imagem Assistida por Computador , Angiografia por Ressonância Magnética/métodos , Simulação por Computador , Humanos , Perna (Membro)/irrigação sanguínea , Imagens de Fantasmas
11.
Surg Radiol Anat ; 36(5): 503-5, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24026392

RESUMO

PURPOSE: Os intermetatarseum is a rare accessory bone of the forefoot and usually situated between the base of the first and second metatarsals. Most of the cases are asymptomatic and diagnosed incidentally. Here, we report a rare form of os intermetatarseum presented with bilateral dorsal foot pain and to the authors' knowledge, it is the first case which includes computerized tomography (CT) and magnetic resonance imaging (MRI) findings. METHODS: A 23-year-old male complained of localized bump at the dorsum of the both feet underwent bilateral anteroposterior foot radiograms which was unremarkable and then CT and MRI were performed. RESULTS: MRI of both feet demonstrated osseous structures in relation with medial os cuneiforme. Computerized tomography demonstrated bilateral os intermetatarsea fused with medial os cuneiforme. CONCLUSIONS: It is important for radiologist to know that os intermetatarseum can be presented as dorsal foot pain. Due to its position, it is difficult to demonstrate os intermetatarseum in plain radiographs, CT and MRI should be performed in clinically suggestive cases.


Assuntos
Ossos do Metatarso/anormalidades , Humanos , Masculino , Ossos do Metatarso/diagnóstico por imagem , Dor/etiologia , Radiografia , Adulto Jovem
12.
Indian J Otolaryngol Head Neck Surg ; 76(2): 2078-2081, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38566681

RESUMO

Otitic Hydrocephalus (OH) is one of the most significant life-threatening complications of otological infections. Given their low prevalence and non-specific ear symptoms, this complication requires a high index of suspicion for diagnosis. In this case report, we aim to provide an analysis of OH and describe common clinical signs and symptoms, treatment options, morbidity and mortality.

13.
Hepatol Forum ; 4(2): 78-81, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37250927

RESUMO

This study is written to report a case of 67-year-old female with known autoimmune hepatitis (AIH) who developed balance and walking difficulties. Clinical and imaging investigations were more suggestive of AIH suffering from lymphoproliferative disease. To identify the underlying suspected lymphoproliferative disease, series of brain scans were performed, which showed multiple brain lesions. This is a report on a striking case of multiple contrast enhanced brain lesions discovered in an AIH patient that was resolved upon withdrawal of azathioprine. Many side effects of azathioprine are acknowledged around the world; however, to the very best of our knowledge, an article on azathioprine inducing suspected malignancy was never reported.

14.
J Biomater Sci Polym Ed ; 34(12): 1660-1682, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-36756763

RESUMO

In this study, nanoparticles of amoxicillin (AMX) were prepared using chitosan (CHI) and polyethylene glycol (PEG). The physicochemical properties of the particles were investigated by FT-IR, DSC, SEM, and zeta potential analyses. The nanoparticles showed a spherical shape, and the average size of formulations was within the range of 696.20 ± 24.86 - 359.53 ± 7.41 nm. Zeta potential data demonstrated that the formulations had positive surface charges with a zeta potential range of 21.38 ± 2.28 - 7.73 ± 1.66 mV. FTIR analysis showed that the drug was successfully entrapped in the nanoparticles. DSC results suggested that the drug was present in amorphous form in the polymer matrix. In vitro release studies demonstrated that the release pattern consisted of two phases, with an initial burst release followed by a controlled and sustained release. The MTT assay results on mouse fibroblast cell line indicated that the prepared formulations did not affect the viability of the cells. In the in vitro antibacterial activity test, it was found that the drug-loaded nanoparticles have AMX-equivalent antibacterial activity against E. coli, and S. aureus. These findings revealed that the obtained nanoparticles might be a promising and safe nanocarrier system for efficient delivery of AMX.


Amoxicillin has been encapsulated in PEG-CHI nanoparticles.The structure of nanoparticles was investigated by SEM, FTIR, and DSC studies.The nanoparticles showed an initial fast release followed by a slow release.PEG-CHI nanoparticles displayed equivalent antibacterial activity to amoxicillin, and a non-cytotoxic profile in healthy cells.


Assuntos
Antineoplásicos , Quitosana , Nanopartículas , Animais , Camundongos , Amoxicilina/farmacologia , Polietilenoglicóis/química , Quitosana/química , Staphylococcus aureus , Escherichia coli , Espectroscopia de Infravermelho com Transformada de Fourier , Sistemas de Liberação de Medicamentos/métodos , Antibacterianos/farmacologia , Antibacterianos/química , Nanopartículas/química , Portadores de Fármacos/química , Tamanho da Partícula
15.
Eur J Radiol ; 167: 111088, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37713968

RESUMO

PURPOSE: To investigate the quality of reporting in radiomics research, with a focus on the most basic technical parameters. METHODS: A PubMed literature search was conducted to identify original studies on radiomics (last search: January 2, 2023). Following a sample size calculation with an a priori power analysis, a random sample of the radiomic literature was collected. In addition to baseline characteristics, the key aspects of radiomic software, resampling, and discretization were evaluated. Agreement between raters was analyzed. Disagreements were resolved through consensus. RESULTS: A sample of 87 publications was evaluated. Most publications (89%; 77/87) were retrospective. They were conducted predominantly with private data (87%; 76/87) at a single institution (77%; 67/87) without external validation (90%; 78/87). 69% (60/87) of the papers reported the radiomic software used (p < 0.001), with nearly half (43%; 26/60) omitting the version. 37% (32/87) reported the resampling size (p = 0.018), while 22% (7/32) did not report using iso-voxel resampling. 34% (30/87) reported the discretization parameters (p < 0.01), but more than three-quarters (77%; 23/30) did not experiment with different discretization parameters. A wide range of discretization parameter values were reported. Most papers (79%; 69/87) failed to report all three essential items simultaneously (p < 0.001). CONCLUSION: Even the essential radiomic parameters that are usually displayed on the user interface of radiomic software tools were poorly reported in radiomics-related publications. This issue of transparency may require additional action from researchers, editors, and reviewers in the form of adopting more stringent reporting standards (e.g., checklists, guidelines).


Assuntos
Lista de Checagem , Projetos de Pesquisa , Humanos , Estudos Retrospectivos , Consenso , Software
16.
Acad Radiol ; 30(10): 2254-2266, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-36526532

RESUMO

RATIONALE AND OBJECTIVES: Reproducibility of artificial intelligence (AI) research has become a growing concern. One of the fundamental reasons is the lack of transparency in data, code, and model. In this work, we aimed to systematically review the radiology and nuclear medicine papers on AI in terms of transparency and open science. MATERIALS AND METHODS: A systematic literature search was performed in PubMed to identify original research studies on AI. The search was restricted to studies published in Q1 and Q2 journals that are also indexed on the Web of Science. A random sampling of the literature was performed. Besides six baseline study characteristics, a total of five availability items were evaluated. Two groups of independent readers including eight readers participated in the study. Inter-rater agreement was analyzed. Disagreements were resolved with consensus. RESULTS: Following eligibility criteria, we included a final set of 194 papers. The raw data was available in about one-fifth of the papers (34/194; 18%). However, the authors made their private data available only in one paper (1/161; 1%). About one-tenth of the papers made their pre-modeling (25/194; 13%), modeling (28/194; 14%), or post-modeling files (15/194; 8%) available. Most of the papers (189/194; 97%) did not attempt to create a ready-to-use system for real-world usage. Data origin, use of deep learning, and external validation had statistically significantly different distributions. The use of private data alone was negatively associated with the availability of at least one item (p<0.001). CONCLUSION: Overall rates of availability for items were poor, leaving room for substantial improvement.


Assuntos
Inteligência Artificial , Medicina Nuclear , Humanos , Reprodutibilidade dos Testes , Radiografia , Cintilografia
17.
Eur J Radiol ; 163: 110830, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37119709

RESUMO

PURPOSE: The purpose of this study was to conduct a meta-research of radiomics-related articles for the publication of negative results, with a focus on the leading clinical radiology journals due to their purportedly high editorial standards. METHODS: A literature search was performed in PubMed to identify original research studies on radiomics (last search date: August 16th, 2022). The search was restricted to studies published in Q1 clinical radiology journals indexed by Scopus and Web of Science. Following an a priori power analysis based on our null hypothesis, a random sampling of the published literature was conducted. Besides the six baseline study characteristics, a total of three items about publication bias were evaluated. Agreement between raters was analyzed. Disagreements were resolved through consensus. Statistical synthesis of the qualitative evaluations was presented. RESULTS: Following a priori power analysis, we included a random sample of 149 publications in this study. Most of the publications were retrospective (95%; 142/149), based on private data (91%; 136/149), centered on a single institution (75%; 111/149), and lacked external validation (81%; 121/149). Slightly fewer than half (44%; 66/149) made no comparison to non-radiomic approaches. Overall, only one study (1%; 1/149) reported negative results for radiomics, yielding a statistically significant binomial test (p < 0.0001). CONCLUSION: The top clinical radiology journals almost never publish negative results, having a strong bias toward publishing positive results. Almost half of the publications did not even compare their approach with a non-radiomic method.


Assuntos
Publicações Periódicas como Assunto , Radiologia , Humanos , Viés de Publicação , Resultados Negativos , Estudos Retrospectivos
18.
Eur J Radiol ; 165: 110893, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37285646

RESUMO

OBJECTIVE: To evaluate the reliability of consensus-based segmentation in terms of reproducibility of radiomic features. METHODS: In this retrospective study, three tumor data sets were investigated: breast cancer (n = 30), renal cell carcinoma (n = 30), and pituitary macroadenoma (n = 30). MRI was utilized for breast and pituitary data sets, while CT was used for renal data set. 12 readers participated in the segmentation process. Consensus segmentation was created by making corrections on a previous region or volume of interest. Four experiments were designed to evaluate the reproducibility of radiomic features. Reliability was assessed with intraclass correlation coefficient (ICC) with two cut-off values: 0.75 and 0.9. RESULTS: Considering the lower bound of the 95% confidence interval and the ICC threshold of 0.90, at least 61% of the radiomic features were not reproducible in the inter-consensus analysis. In the susceptibility experiment, at least half (54%) became non-reproducible when the first reader is replaced with a different reader. In the intra-consensus analysis, at least about one-third (32%) were non-reproducible when the same second reader segmented the image over the same first reader two weeks later. Compared to inter-reader analysis based on independent single readers, the inter-consensus analysis did not statistically significantly improve the rates of reproducible features in all data sets and analyses. CONCLUSIONS: Despite the positive connotation of the word "consensus", it is essential to REMIND that consensus-based segmentation has significant reproducibility issues. Therefore, the usage of consensus-based segmentation alone should be avoided unless a reliability analysis is performed, even if it is not practical in clinical settings.


Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Humanos , Reprodutibilidade dos Testes , Estudos Retrospectivos , Consenso , Carcinoma de Células Renais/patologia , Neoplasias Renais/patologia , Processamento de Imagem Assistida por Computador/métodos
19.
Oral Radiol ; 38(4): 625-629, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35678962

RESUMO

Stafne bone cavity (SBC) is a bone defect which appears unilaterally round or oval shaped radiolucent area with well-defined border. The most common location of the defect is the mandibular molar area at the lingual side of the mandible, below the mandibular canal. Additionally other rarer variants of SBC, anterior lingual, buccal aspect of ascending ramus, and lingual aspect of ascending ramus are also reported. In this paper, a rare case of posterior and anterior variant of double SBCs with buccal cortical bone perforation was presented. An 83-year-old male patient was referred to our clinic for a routine dental examination. Panoramic examination presented two well-defined radiolucent areas. One was located at the right posterior region of the mandible, below the inferior alveolar canal and the second in the region of right canine-premolar area, anterior of the mental foramen. Cone beam computed tomography also confirmed the defects. Magnetic resonance imaging of patient showed that posterior variant was filled with part of submandibular gland and anterior variant was filled with part of sublingual gland. The diagnosis was made as double SBCs and the patient was informed about the lesions.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Mandíbula , Animais , Dente Pré-Molar , Tomografia Computadorizada de Feixe Cônico/métodos , Masculino , Mandíbula/diagnóstico por imagem , Dente Molar , Radiografia Panorâmica
20.
Turk J Pediatr ; 64(3): 519-530, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35899565

RESUMO

BACKGROUND: The tumor localization/extent and imaging characteristics of rhabdomyosarcomas (RMSs) especially parameningeal type, could overlap with the common tumors of the head and neck (H&N) such as lymphoma and nasopharyngeal carcinoma (NPC). Our goal was to investigate magnetic resonance imaging (MRI) features that could favor the diagnosis of RMS over lymphoma and NPC in H&N region. METHODS: Pretreatment MRI of 42 pediatric patients (mean: 9.7±5.1 years, min-max: 2-18 years) with a recent diagnosis of RMS (n=12), lymphoma (n=14) and NPC (n=16) were retrospectively studied. Tumor localization, extension and spread were evaluated. Signal and enhancement characteristics of the tumors and the presence of necrosis were noted. ADC values were measured by using both the small sample and single slice methods. For comparison of three groups, the Kruskal Wallis test and Pairwise comparisons were used. The intra-class correlation coefficient (ICC) was calculated for the assessment of inter-observer agreement. RESULTS: Nasopharynx ±parapharyngeal space involvement was detected in 58.3% of RMSs. Rhabdomyosarcoma was more heterogeneous in T2 images compared to lymphoma (p=0.014). Rhabdomyosarcoma showed significantly higher frequency of heterogeneous enhancement (p < 0.001) and necrosis (p < 0.001) among these tumors. The mean ADC values of lymphoma were significantly lower than the values of RMS (p < 0.001) and NPC (p < 0.01) for both observers. The mean ADC values were higher in RMSs than NPCs (p > 0.05). Intra-class correlation in ADC measurements was higher for the single slice method (ICC=0.997) than the small sample method (ICC=0.989). CONCLUSIONS: Rhabdomyosarcoma tends to have higher ADC values than lymphoma and has a higher frequency of heterogeneous enhancement and necrotic parts than both lymphoma and nasopharyngeal carcinoma. These features could help radiologists to differentiate RMS from the above-mentioned mimickers.


Assuntos
Neoplasias de Cabeça e Pescoço , Linfoma , Neoplasias Nasofaríngeas , Rabdomiossarcoma , Criança , Imagem de Difusão por Ressonância Magnética/métodos , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Humanos , Linfoma/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Carcinoma Nasofaríngeo , Neoplasias Nasofaríngeas/diagnóstico por imagem , Neoplasias Nasofaríngeas/patologia , Necrose , Estudos Retrospectivos , Rabdomiossarcoma/diagnóstico por imagem
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