Detalhe da pesquisa
1.
Stimulation of an anti-tumor immune response with "chromatin-damaging" therapy.
Cancer Immunol Immunother
; 70(7): 2073-2086, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33439292
2.
Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.
Proc Natl Acad Sci U S A
; 113(7): E874-83, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26831100
3.
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist.
Proc Natl Acad Sci U S A
; 110(20): E1857-66, 2013 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23630282
4.
Hypoxia suppresses conversion from proliferative arrest to cellular senescence.
Proc Natl Acad Sci U S A
; 109(33): 13314-8, 2012 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22847439
5.
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.
J Immunol
; 189(10): 4719-27, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23045613
6.
Combined stimulation of Toll-like receptor 5 and NOD1 strongly potentiates activity of NF-κB, resulting in enhanced innate immune reactions and resistance to Salmonella enterica serovar Typhimurium infection.
Infect Immun
; 81(10): 3855-64, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897616
7.
Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9.
Cell Death Discov
; 7(1): 266, 2021 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34584068
8.
A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications.
Commun Biol
; 4(1): 466, 2021 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33846531
9.
TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects.
PLoS One
; 15(2): e0227940, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32027657
10.
Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation.
Radiat Res
; 187(5): 570-580, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28323577
11.
The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism.
Oncotarget
; 7(3): 2936-50, 2016 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26655090
12.
A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.
PLoS One
; 9(1): e85587, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24454895
13.
Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice.
Oncotarget
; 5(3): 802-14, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24583651
14.
Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy.
Int J Radiat Oncol Biol Phys
; 83(1): 228-34, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22000579
15.
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.
Science
; 320(5873): 226-30, 2008 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18403709
16.
Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice.
Cancer Res
; 66(19): 9356-61, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17018587
17.
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
Nat Chem Biol
; 2(9): 474-9, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16862141
18.
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.
Proc Natl Acad Sci U S A
; 102(48): 17448-53, 2005 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16287968
19.
Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells.
Proc Natl Acad Sci U S A
; 101(18): 7112-7, 2004 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15118089