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1.
J Oral Maxillofac Surg ; 82(2): 199-206, 2024 02.
Artigo em Inglês | MEDLINE | ID: mdl-38040026

RESUMO

BACKGROUND: An increase in severity and a decrease in incidence of craniomaxillofacial fractures (CMFs) were identified during the first several months of the SARS-CoV-2 pandemic. It is unclear if these changes have persisted in the current timeframe. PURPOSE: The investigators hypothesize that the incidence and severity of CMF will not return to baseline prepandemic (control) levels as the pandemic stabilizes and becomes endemic. STUDY DESIGN, SETTING, SAMPLE: This retrospective cohort study enrolled subjects who presented to Harborview Medical Center a Level 1 trauma center for the evaluation and management of CMF. Inclusion criteria were 1) Presentation timeline 2018 through 2022, 2) CMF identified by the 10th International Classification of Disease. Exclusion criteria were: 1) Undocumented etiology of facial fracture and 2) inadequate/unclear documentation otherwise. PREDICTOR/EXPOSURE/INDEPENDENT VARIABLE: The predictor variable was year of injury relating to the start of the pandemic. The groups were the prepandemic (2018, 2019) and postpandemic (2020, 2021. 2022). MAIN OUTCOME VARIABLES: The primary outcome variable was the CMF diagnosis identified using the corresponding International Classification of Disease, 10th Edition codes. The secondary outcome variables were mechanism of injury and injury severity. COVARIATES: The covariates were age, sex, race/ethnicity, admission status, alcohol intoxication, toxicology screen, reimbursement source, abuse reported, and abuse investigated. ANALYSES: Univariate and bivariate analyses were performed with statistical significance at P < .05. RESULTS: The sample was composed of 5203 subjects. The annual volumes of subjects presenting with CMF were consistent over the study period (2018, 2019, 2020, 2021, 2022 n = 1018, 963, 1020, 1062, 1140, respectively). The incidence of Hispanics increased (2018, 2019, 2020, 2021, 2022: 11.1, 9.6, 12.2, 13.9, 13.2% (P < .05)) as did firearm CMF injuries (2018, 2019, 2020, 2021, 2022: 4.13, 4.98, 4.71, 7.16, 6.75% (P < .05)). The Injury Severity Score and Abbreviated Injury Scale were both lower postpandemic compared to prepandemic; mean Injury Severity Score post [18.27 ± 12.46] versus pre [19.25 ± 12.89] (P < .05), mean Abbreviated Injury Scale post [2.94 ± 1.15] versus pre [3.04 ± 1.14] (P < .05). CONCLUSIONS AND RELEVANCE: While the severity of CMF decreased postpandemic, Hispanic and firearm CMF increased. The overall CMF incidence remained the same. The significant rise in firearm injuries warrants further study.


Assuntos
COVID-19 , Armas de Fogo , Ferimentos por Arma de Fogo , Humanos , SARS-CoV-2 , Incidência , Estudos Retrospectivos , COVID-19/epidemiologia
2.
Artigo em Inglês | MEDLINE | ID: mdl-38583488

RESUMO

BACKGROUND: The prevalence of maxillofacial and head injuries associated with electric scooters (e-scooter, ES) has risen in concordance with its popularity. PURPOSE: The purpose of this study was to compare maxillofacial and head injury location, type, and severity related to ES and bicycle accidents and to identify factors contributing to injury severity. STUDY DESIGN, SETTING, SAMPLE: The authors implemented a multicenter retrospective cohort study in Seattle, Washington, and enrolled a sample of ES riders and bicyclists who sustained maxillofacial injuries between September 2020 and September 2022. The exclusion criteria included nonmotorized scooters, motorized bicycles, injuries with other operators, or vehicles, and pre-evaluation deaths. PREDICTOR VARIABLE: The predictor variable was vehicle type, bicycle or ES. OUTCOME VARIABLES: The outcome variables included maxillofacial injury location, distinguished by horizontal facial thirds and injury type, defined as hard or soft tissue. Associated head injury types were also reported as hard (calvaria) or soft (scalp) tissue injuries. The severity of these injuries was quantified using both the injury severity score and the face and head abbreviated injury scale. COVARIATES: Demographic, injury, and treatment-related variables were collected. ANALYSES: Bivariate, multivariate, and regression statistics were computed. Statistical significance was P < .05. RESULTS: The final sample was composed of 205 total subjects, of which 52 (25.4%) were in the ES group and 153 (74.6%) in the bicycle group. Isolated midface injuries were the most common hard tissue location in the ES (15.4%) and bicycle (29.4%) groups. The most common soft tissue injury location included the upper face and midface in the ES group (19.2%) and the midface in the bicycle group (22.9%). Both hard and soft tissue head injuries were more prevalent in the ES group (P < .0002 and P < .0001). Moreover, intracranial injuries were seen in 36.5% of ES subjects compared to 9.8% bicycle subjects (P < .0001). Between the two groups there was no difference in maxillofacial injury severity, but head injuries were more severe in the ES group (P < .0002). Using regression analysis, drug use was found to have a significant impact on the mean injury severity score (P < .002) and helmet use did not have significant impact on face or head injury severity. CONCLUSION: Maxillofacial injury location, type, and severity are comparable among ES and bicycles. However, ES riders are at greater risk of severe head injuries compared to bicycles, and riding while intoxicated has the greatest effect on injury severity.

3.
J Oral Maxillofac Surg ; 81(4): 499-503, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36577505

RESUMO

PURPOSE: There is no consensus on the ideal treatment of odontogenic keratocysts (OKCs). Certain risk factors may modify the disease recurrence rate. The purpose of this study was: 1) to estimate the incidence of OKC recurrence in a statistically rigorous manner; and 2) to identify risk factors associated with OKC recurrence. METHODS: The investigators designed and implemented a retrospective cohort study and enrolled a sample derived from the population of patients presenting to the Department of Oral and Maxillofacial Surgery outpatient clinics at the University of Washington School of Dentistry and Harborview Medical Center for evaluation and management of OKCs between January 1, 2010, and December 31, 2020. Predictor variables included demographics (age, gender), radiographic characteristics (location of lesion, locularity, size, and cortical perforation), and type of operation performed (decompression + cystectomy, enucleation ± adjuvant therapy, or resection). The primary outcome variable was time to recurrent disease, defined as the time from treatment to radiographic or clinical evidence of a new lesion (recorded in months). Kaplan-Meier analysis was used to estimate median time to recurrence, and Cox proportional hazards models were used to identify covariates statistically associated with recurrent disease (P ≤ .05). RESULTS: The sample was composed of 60 subjects with 63 previously untreated lesions. Eight subjects (13%) developed a recurrent lesion during the study interval with a median time to recurrence of 31 (interquartile range, 24 to 48) months. One of the 8 recurrences occurred within 12 months of treatment and 7 of the 8 recurrences occurred more than 21 months after treatment. Based on using Kaplan-Meier analysis, the 5-year incidence of disease recurrence was estimated to be 34%. Lesions with cortical perforation were 8.3 times more likely to recur (95% confidence interval [1.7, 41.3]; P-value = .01), and multilocular lesions were 10.6 times more likely to recur (95% confidence interval [1.3, 86.9]; P-value = .03). The sample size was the limiting factor to performing regression analyses. CONCLUSIONS: Virtually every publication on OKCs to date reports frequencies of disease recurrence rather than applying appropriate survival analyses commonly used to estimate outcomes in cancer research. Failure to use the appropriate statistical analyses underestimates the risk of disease recurrence. Our study is no exception. The estimated frequency of disease recurrence during the study interval was 13% (8/60). When survival analyses are applied that account for varying months of follow-up, the incidence of disease recurrence is 34 per 100 per 5 years. We recommend the application of time-to-event analyses in the study of disease entities with the potential for recurrence.


Assuntos
Cistos Odontogênicos , Tumores Odontogênicos , Humanos , Estudos Retrospectivos , Recidiva Local de Neoplasia , Incidência , Tumores Odontogênicos/cirurgia , Cistos Odontogênicos/diagnóstico por imagem , Cistos Odontogênicos/epidemiologia , Cistos Odontogênicos/cirurgia , Recidiva
4.
Proc Natl Acad Sci U S A ; 117(27): 15443-15449, 2020 07 07.
Artigo em Inglês | MEDLINE | ID: mdl-32571905

RESUMO

The assassination of Julius Caesar in 44 BCE triggered a power struggle that ultimately ended the Roman Republic and, eventually, the Ptolemaic Kingdom, leading to the rise of the Roman Empire. Climate proxies and written documents indicate that this struggle occurred during a period of unusually inclement weather, famine, and disease in the Mediterranean region; historians have previously speculated that a large volcanic eruption of unknown origin was the most likely cause. Here we show using well-dated volcanic fallout records in six Arctic ice cores that one of the largest volcanic eruptions of the past 2,500 y occurred in early 43 BCE, with distinct geochemistry of tephra deposited during the event identifying the Okmok volcano in Alaska as the source. Climate proxy records show that 43 and 42 BCE were among the coldest years of recent millennia in the Northern Hemisphere at the start of one of the coldest decades. Earth system modeling suggests that radiative forcing from this massive, high-latitude eruption led to pronounced changes in hydroclimate, including seasonal temperatures in specific Mediterranean regions as much as 7 °C below normal during the 2 y period following the eruption and unusually wet conditions. While it is difficult to establish direct causal linkages to thinly documented historical events, the wet and very cold conditions from this massive eruption on the opposite side of Earth probably resulted in crop failures, famine, and disease, exacerbating social unrest and contributing to political realignments throughout the Mediterranean region at this critical juncture of Western civilization.


Assuntos
Mudança Climática/história , Clima Frio/efeitos adversos , Desastres/história , Mundo Romano/história , Erupções Vulcânicas/efeitos adversos , Alaska , Clima , Produtos Agrícolas/história , Fome Epidêmica/história , História Antiga , Camada de Gelo , Região do Mediterrâneo , Política , Erupções Vulcânicas/história
5.
J Oral Maxillofac Surg ; 79(10): 2010-2015, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34245704

RESUMO

PURPOSE: Oral and maxillofacial surgeons (OMSs) must manage postoperative pain control for patients who take illicit substances. The purpose of this study was to measure and compare the amount of opioid prescribing between patients with and without self-reported substance use history (SUH) by OMSs after third molar (M3) removal. MATERIALS AND METHODS: The investigators implemented a retrospective cohort study and enrolled a sample of subjects who had M3 removal between January 1, 2019 through December 31, 2019. The primary predictor variable was SUH coded as yes (SUH+) or no (SUH-). The primary and secondary outcome variables were prescribed morphine milligram equivalents (MMEs) and number of postoperative visits due to inadequate pain control (IPC), respectively. Other variables were age, gender, payor, provider, anesthesia, and procedure specific. Descriptive, bivariate, and multiple linear regression models were computed. RESULTS: The sample included 1,112 subjects with a mean age of 25 ± 9 years; 61.2% were female. Of the 1,112 subjects, 198 (17.8%) reported a SUH. Mean MMEs were 70.9 ± 27.9 and 63.4 ± 28.8 in the SUH+ and SUH- groups, respectively (P ≤ .001). An adjusted linear regression model showed a non-significant association between SUH and MMEs prescribed (P = .50). The study showed a non-significant increase (P = .15) in the proportion of patients with IPC in the SUH- group (4.1%) versus the SUH+ group (2.0%). CONCLUSIONS: The results suggest that 10% more opioids were prescribed for postoperative pain after M3 removal for patients with SUH, though after adjustment, the amount may not be clinically significant. Postoperative pain management after M3 removal in patients with SUH, on average, can be managed in a similar manner as for patients without SUH.


Assuntos
Analgésicos Opioides , Transtornos Relacionados ao Uso de Substâncias , Adolescente , Adulto , Analgésicos Opioides/uso terapêutico , Feminino , Humanos , Dente Serotino/cirurgia , Cirurgiões Bucomaxilofaciais , Dor Pós-Operatória/tratamento farmacológico , Padrões de Prática Odontológica , Padrões de Prática Médica , Estudos Retrospectivos , Transtornos Relacionados ao Uso de Substâncias/complicações , Adulto Jovem
6.
J Oral Maxillofac Surg ; 79(5): 1091-1097, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33421417

RESUMO

PURPOSE: The purpose of this study was to understand the impact of social distancing policies enacted during the COVID-19 pandemic on the epidemiology of oral and maxillofacial fractures at an urban, Level I trauma center in the United States. MATERIALS AND METHODS: The investigators designed a retrospective cohort study and enrolled a sample of 883 subjects who presented for evaluation of oral and maxillofacial fractures (OMF) between March 1 and June 30 in the years 2018 through 2020. The primary predictor variable was the evaluation of OMF during a period with social distancing policies (2020 - experimental group) or without social distancing policies in place (2018 or 2019 - control group). The primary outcome variables were the facial fracture diagnosis, the abbreviated injury scale (AIS), injury severity score (ISS), and the mechanism of injury. Appropriate univariate and bivariate statistics were computed, and the level of significance was set at P < .05 for all tests. RESULTS: The number of subjects presenting with OMF was lower during the period of social distancing (n = 235 in 2020) than during the periods without (2018: n = 330; 2019: n = 318). During the period of social distancing, there were more individuals who presented secondary to assault, whereas fewer individuals presented secondary to falls (P = .05). On average, those who presented in 2020 had more severe oral and maxillofacial injuries (mean AIS = 3.2 ± 1.2 in 2020 vs 3.0 ± 1.1 in 2019 and 3.0 ± 1.1 in 2018. P = .03) and more overall injuries (mean ISS = 20.7 ± 13.1 in 2020 vs 19.2 ± 12.5 in 2019; 17.8 ± 12.8 in 2018. P = .03). CONCLUSIONS: The investigators found that during the period of social distancing through the COVID-19 pandemic, the number of OMF cases decreased but that the severity of oral and maxillofacial and overall injuries was higher.


Assuntos
COVID-19 , Traumatismos Maxilofaciais , Humanos , Traumatismos Maxilofaciais/epidemiologia , Pandemias , Distanciamento Físico , Estudos Retrospectivos , SARS-CoV-2 , Estados Unidos/epidemiologia
7.
J Oral Maxillofac Surg ; 79(9): 1882-1890, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34111432

RESUMO

PURPOSE: To review treatment of osteomyelitis of the jaw (OMJ) and determine whether antibiotic route and/or length of administration impacts resolution of infection postsurgically. METHODS: The investigators designed a retrospective cohort study enrolling a sample of patients treated at Harborview Medical Center from January 1, 2009 to December 31, 2019. The primary predictor variable was antibiotic administration route: oral (PO) only, intravenous (IV) only, IV transitioned to PO (IV + PO), or none. The secondary predictor was duration of antibiotic therapy (≤6 weeks or >6 weeks). The primary outcome variable was resolution of infection at 2 months follow-up posttreatment completion. The secondary outcome variable was number of surgeries to resolution of infection. Descriptive, bivariate, and multiple linear regression statistics were computed, with statistical significance set at P < .05. RESULTS: Sixty-seven individuals met inclusion criteria (38 male), mean age 51 years (18 to 88). Forty-nine (73%) received PO antibiotics, 12 (18%) IV + PO, 3 (4%) IV, and 3 (4%) none. Both PO and IV antibiotics were associated with clinical resolution (P = .022, .005, respectively) compared with debridement alone. Antibiotic duration of ≤6 weeks compared with >6 weeks was not significant. Seventy-six percent (51 of 67) required only 1 surgery. In the multivariate logistic regression, PO was associated with clinical resolution (P = .025, OR = 5.05). Penicillin allergy (P = 0.049, OR = 0.223) and diabetes (P = .008, OR = 0.104) were adversely associated with outcome. CONCLUSIONS: OMJ was successfully treated with oral antibiotics and surgery. Prescribing 6 weeks of IV antibiotics may be antiquated. Clinicians should consider oral penicillins as first line whenever possible. Further studies are recommended.


Assuntos
Antibacterianos , Osteomielite , Administração Intravenosa , Administração Oral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteomielite/tratamento farmacológico , Estudos Retrospectivos , Adulto Jovem
8.
Proc Natl Acad Sci U S A ; 114(38): 10035-10040, 2017 09 19.
Artigo em Inglês | MEDLINE | ID: mdl-28874529

RESUMO

Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ∼17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ∼192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source. Extensive fallout from these massive eruptions has been found >2,800 km from Mount Takahe. Sulfur isotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion. Rather than a highly improbable coincidence, circulation and climate changes extending from the Antarctic Peninsula to the subtropics-similar to those associated with modern stratospheric ozone depletion over Antarctica-plausibly link the Mount Takahe eruptions to the onset of accelerated Southern Hemisphere deglaciation ∼17.7 ka.

10.
J Oral Maxillofac Surg ; 77(12): 2377-2385, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31563444

RESUMO

PURPOSE: Despite increased awareness of sexually harassing behavior (SHB) and national movements such as #MeToo, SHB remains a persistent problem for women training in medical and surgical fields. The aims of the present study were to 1) estimate the prevalence and nature of SHBs in a set of female oral and maxillofacial surgery (OMS) residents and practicing surgeons in the United States; 2) measure and describe the subjective effects of SHBs on the professional development of female OMSs; and 3) measure the effect of SHB education in training programs and its association with its prevalence. MATERIALS AND METHODS: A cross-sectional study was conducted using an adapted validated Sexual Experiences questionnaire. The 22-question survey was e-mailed to female members of the American Association of Oral and Maxillofacial Surgeons' women's clinical interest group. Descriptive statistics and bivariate analyses were computed using age and SHB training as predictor variables for the prevalence of SHBs. RESULTS: A total of 89 participants were e-mailed, and 67 responded (75%). Of the 67 respondents, 53 were practicing OMSs (79%) and 14 were OMS residents (21%). Of the 67 respondents, 96% had experienced at least 1 form of SHB. Specifically, 96% reported gender harassment, 52% unwanted sexual attention, and 9% sexual coercion. An "intimidating, hostile, or offensive environment" was associated with "having a negative effect on yourself as a professional" (P < .01). Of the respondents, 61% had not received education on SHBs during training, with those older than 35 years least likely to have received SHB training (P = .001). CONCLUSIONS: Our results have shown that SHBs received by female OMSs is common. Our findings suggest that SHBs erodes the personal confidence and career development of female OMS practitioners and residents. We recommend SHB educational training for all residents, faculty, and staff to ensure personal and academic growth in a safe environment.


Assuntos
Internato e Residência , Assédio Sexual , Cirurgia Bucal , Estudos Transversais , Feminino , Humanos , Cirurgiões Bucomaxilofaciais , Cirurgia Bucal/educação , Inquéritos e Questionários , Estados Unidos
11.
J Oral Maxillofac Surg ; 77(2): 240-246, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30102879

RESUMO

PURPOSE: Several studies of surgical specialties have shown disparities in measures of research productivity and academic rank between female and male surgeons. The purpose of this work was to measure the role of surgeon gender in academic success in oral and maxillofacial surgery. MATERIALS AND METHODS: We performed a cross-sectional study of full-time academic oral and maxillofacial surgeons (OMSs) in the United States as of June 2017. The primary study variable was surgeon gender (male or female). The primary outcome variable was research productivity assessed using 2 different parameters: 1) h index (number of publications h with at least h citations each) and 2) academic rank. The other study variables were demographic characteristics potentially related to the outcome measures. Descriptive, bivariate, and regression statistics were computed. RESULTS: The study sample comprised 306 full-time academic OMSs, 53 (17.3%) of whom were women. On average, female OMSs had shorter academic careers (mean time since completion of training, 11.0 ± 8.2 years for female OMSs vs 22.0 ± 14.1 years for male OMSs; P < .001). There were no other significant differences between male and female OMSs regarding the secondary measures (P ≥ .23). Male OMSs had a higher mean h index than female OMSs (7.1 ± 8.6 vs 5.1 ± 7.9, P = .01). Academic rank was statistically significantly different between female and male OMSs, with a greater proportion of higher ranks seen in male OMSs (P = .001). After adjustment for career length and other confounders or effect modifiers, gender was not an independent predictor of the h index or academic rank (P ≥ .22). CONCLUSIONS: Although female surgeons represent a minority of full-time academic OMSs, academic success measured using research productivity and academic rank was not associated with gender.


Assuntos
Cirurgia Bucal , Estudos Transversais , Eficiência , Feminino , Humanos , Masculino , Cirurgiões Bucomaxilofaciais , Estados Unidos
12.
Proc Natl Acad Sci U S A ; 111(24): 8753-8, 2014 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-24889624

RESUMO

In the modern climate, the ocean below 2 km is mainly filled by waters sinking into the abyss around Antarctica and in the North Atlantic. Paleoproxies indicate that waters of North Atlantic origin were instead absent below 2 km at the Last Glacial Maximum, resulting in an expansion of the volume occupied by Antarctic origin waters. In this study we show that this rearrangement of deep water masses is dynamically linked to the expansion of summer sea ice around Antarctica. A simple theory further suggests that these deep waters only came to the surface under sea ice, which insulated them from atmospheric forcing, and were weakly mixed with overlying waters, thus being able to store carbon for long times. This unappreciated link between the expansion of sea ice and the appearance of a voluminous and insulated water mass may help quantify the ocean's role in regulating atmospheric carbon dioxide on glacial-interglacial timescales. Previous studies pointed to many independent changes in ocean physics to account for the observed swings in atmospheric carbon dioxide. Here it is shown that many of these changes are dynamically linked and therefore must co-occur.


Assuntos
Camada de Gelo , Oceanos e Mares , Algoritmos , Regiões Antárticas , Ciclo do Carbono , Clima , Simulação por Computador , Modelos Teóricos , Oceanografia , Água do Mar , Fatores de Tempo , Movimentos da Água
13.
J Oral Maxillofac Surg ; 74(10): 1983-99, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27137436

RESUMO

PURPOSE: Osteonecrosis of the jaw (ONJ) is an established side effect of intravenous bisphosphonates and other antiresorptive medications. Although bisphosphonates are frequently prescribed for patients with the skeletal disorder fibrous dysplasia (FD), there are no reports of ONJ in this population. This has led some to conclude that patients with FD are at low risk for the development of bisphosphonate-related ONJ. PATIENTS AND METHODS: Patients were evaluated as part of a longstanding FD natural history study at the National Institutes of Health. RESULTS: Of 76 patients with FD who were treated with bisphosphonates, 4 developed ONJ (5.4%). Three patients developed ONJ in areas of FD-affected bone and 1 in an area of normal bone. All 4 patients had features known to be associated with ONJ in the general population, including long-term high-dose intravenous bisphosphonate treatment, periodontal and endodontic infections, and dentoalveolar surgical procedures. CONCLUSIONS: These cases establish ONJ as a potential complication of bisphosphonate treatment in patients with FD. The presence of established risk factors for ONJ in this group of patients with FD suggests that high-risk patients could be identified before the development of ONJ. Clinicians should use caution in prescribing bisphosphonates to patients with FD and should do so only for established indications.


Assuntos
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/etiologia , Displasia Fibrosa Óssea/tratamento farmacológico , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/diagnóstico por imagem , Feminino , Displasia Fibrosa Óssea/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Fatores de Risco , Adulto Jovem
16.
Oral Maxillofac Surg Clin North Am ; 36(3): 379-390, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38705816

RESUMO

Craniofacial fibro-osseous lesions represent a diverse spectrum of pathologic conditions where fibrous tissue replaces healthy bone, resulting in the formation of irregular, woven bone. They are more commonly diagnosed in young people, with treatment strategies dependent on clinical behavior and skeletal maturity. This article discusses the examples of craniofacial fibro-osseous lesions, based on the latest classifications, along with their diagnostic criteria and management.


Assuntos
Displasia Fibrosa Óssea , Humanos , Criança , Diagnóstico Diferencial , Displasia Fibrosa Óssea/diagnóstico por imagem , Displasia Fibrosa Óssea/diagnóstico , Ossos Faciais , Fibroma Ossificante/diagnóstico , Fibroma Ossificante/cirurgia , Displasia Fibrosa Craniofacial/diagnóstico , Displasia Fibrosa Craniofacial/patologia , Neoplasias Cranianas/diagnóstico por imagem , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/patologia
17.
Geobiology ; 22(2): e12595, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38596869

RESUMO

On the anoxic Archean Earth, prior to the onset of oxidative weathering, electron acceptors were relatively scarce, perhaps limiting microbial productivity. An important metabolite may have been sulfate produced during the photolysis of volcanogenic SO2 gas. Multiple sulfur isotope data can be used to track this sulfur source, and indeed this record indicates SO2 photolysis dating back to at least 3.7 Ga, that is, as far back as proposed evidence of life on Earth. However, measurements of multiple sulfur isotopes in some key strata from that time can be challenging due to low sulfur concentrations. Some studies have overcome this challenge with NanoSIMS or optimized gas-source mass spectrometry techniques, but those instruments are not readily accessible. Here, we applied an aqua regia leaching protocol to extract small amounts of sulfur from whole rocks for analyses of multiple sulfur isotopes by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). Measurements of standards and replicates demonstrate good precision and accuracy. We applied this technique to meta-sedimentary rocks with putative biosignatures from the Eoarchean Isua Supracrustal Belt (ISB, >3.7 Ga) and found positive ∆33S (1.40-1.80‰) in four meta-turbidites and negative ∆33S (-0.80‰ and -0.66‰) in two meta-carbonates. Two meta-basalts do not display significant mass-independent fractionation (MIF, -0.01‰ and 0.16‰). In situ Re-Os dating on a molybdenite vein hosted in the meta-turbidites identifies an early ca. 3.7 Ga hydrothermal phase, and in situ Rb-Sr dating of micas in the meta-carbonates suggests metamorphism affected the rocks at ca. 2.2 and 1.7 Ga. We discuss alteration mechanisms and conclude that there is most likely a primary MIF-bearing phase in these meta-sediments. Our new method is therefore a useful addition to the geochemical toolbox, and it confirms that organisms at that time, if present, may indeed have been fed by volcanic nutrients.


Assuntos
Carbonatos , Isótopos de Enxofre/análise
19.
Explor Res Clin Soc Pharm ; 9: 100245, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37065779

RESUMO

Background: There is a scarcity of research in applying the Screening Tool of Older Person's Prescriptions/Screening Tool to Alert to Right Treatment (STOPP/START) criteria to older adults admitted to a psychiatric hospital. Objectives: The primary aim of this study was to determine the extent of polypharmacy in older adults admitted to a psychiatric hospital and to assess the number of STOPP/START triggers detected and recommended by pharmacists. Secondary objectives include evaluating if the STOPP/START criteria is a useful tool to improve prescribing in this setting by assessing the implementation rates of STOPP/START triggers. Methods: This was a prospective, longitudinal study in a psychiatry inpatient setting. Data were collected over a 7-week period. Explicit informed consent was obtained from participants. Medication reconciliation was completed and participants' medications were reviewed using STOPP/START criteria. The number of STOPP/START triggers detected, recommended and implemented was recorded. Results: Sixty-two patients were included in the study. Ninety-four percent were prescribed ≥5 medications and 55% were prescribed ≥10 medications on admission. The mean number of medications prescribed per patient increased from 10 on admission to 12 at follow-up. Of 174 Potential Inappropriate Medications (PIMs) detected, 41% were recommended for review and, of these only 31% were implemented. 27% of the 77 Potential Prescribing Omissions (PPOs) detected were recommended for review and only 23% of those were implemented. Conclusion: STOPP/START did not reduce the prevalence of polypharmacy in this setting. The implementation rates observed in this study were much lower than those observed in non-psychiatric settings.

20.
J Burn Care Res ; 44(4): 992-995, 2023 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-37232409

RESUMO

Establishing a secure airway is critical in the acute phase of facial burns. This case report involving a 9-month-old infant with facial burns describes two techniques of securing an oral airway-trans-alveolar wiring and the application of an intermaxillary fixation (IMF) screw. The use of an IMF screw was more reliable than trans-alveolar wiring, as it allowed a secure airway through the patient's hospitalization, which involved seven additional surgical interventions including five separate facial skin grafts over a 3-month period.


Assuntos
Queimaduras , Traumatismos Faciais , Lesões do Pescoço , Humanos , Lactente , Queimaduras/cirurgia , Parafusos Ósseos , Traumatismos Faciais/cirurgia , Intubação Intratraqueal/métodos
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