Detalhe da pesquisa
1.
Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome.
Alzheimers Dement
; 19(11): 4817-4827, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37021589
2.
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.
Brain
; 143(12): 3653-3671, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33206953
3.
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ß-Cell Mitochondrial Dysfunction in Type 2 Diabetes.
PLoS Genet
; 12(5): e1006033, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27195491
4.
Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter.
Proc Natl Acad Sci U S A
; 110(11): 4315-20, 2013 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23440186
5.
Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome.
FASEB J
; 28(1): 195-205, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24036883
6.
Nerve growth factor metabolic dysfunction in Down's syndrome brains.
Brain
; 137(Pt 3): 860-72, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24519975
7.
Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society.
Mol Syndromol
; 14(2): 89-100, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37064334
8.
Genetic removal of synaptic Zn2+ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity.
Front Neurol
; 13: 882635, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36742045
9.
Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.
Nat Commun
; 12(1): 6208, 2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34707084
10.
Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Mol Syndromol
; 12(4): 202-218, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34421499
11.
A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.
J Neurosci
; 29(13): 4004-15, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339596
12.
Tau isoform expression and regulation in human cortical neurons.
FASEB J
; 22(7): 2357-67, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18263702
13.
Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells.
Cell Rep
; 29(8): 2473-2488.e5, 2019 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31747614
14.
Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society.
Mol Syndromol
; 9(6): 279-286, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30800043
15.
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.
Neuron
; 33(5): 677-88, 2002 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-11879646
16.
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.
Free Radic Biol Med
; 44(12): 2051-7, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18423383
17.
Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome.
Free Radic Biol Med
; 114: 10-14, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28965914
18.
Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.
Aging Cell
; 17(5): e12812, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30028071
19.
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.
J Neurosci
; 26(22): 6011-8, 2006 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-16738244
20.
Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.
J Neurosci
; 26(24): 6533-42, 2006 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-16775141