Detalhe da pesquisa
1.
Parkin and PINK1 mitigate STING-induced inflammation.
Nature
; 561(7722): 258-262, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135585
2.
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Nat Immunol
; 12(11): 1063-70, 2011 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983832
3.
The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration.
Int J Mol Sci
; 24(10)2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37239960
4.
Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.
FASEB J
; 34(9): 12239-12254, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33000527
5.
Coding mutations in NUS1 contribute to Parkinson's disease.
Proc Natl Acad Sci U S A
; 115(45): 11567-11572, 2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30348779
6.
Nurr1Cd11bcre conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons.
Glia
; 68(10): 2057-2069, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32181533
7.
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
Proc Natl Acad Sci U S A
; 114(11): E2253-E2262, 2017 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28246328
8.
Regulation of Synaptic Amyloid-ß Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
J Neurosci
; 37(10): 2639-2655, 2017 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28159908
9.
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Hum Mol Genet
; 25(16): 3515-3523, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27378696
10.
NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.
Hum Mol Genet
; 25(2): 211-22, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503960
11.
Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
EMBO J
; 33(20): 2314-31, 2014 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25201882
12.
Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression.
FASEB J
; 31(8): 3349-3358, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28424350
13.
α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.
J Neurosci
; 36(16): 4408-14, 2016 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27098685
14.
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
Hum Mol Genet
; 24(18): 5299-312, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26123485
15.
Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.
Proc Natl Acad Sci U S A
; 111(12): E1121-9, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616503
16.
Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.
J Neurosci
; 35(30): 10799-814, 2015 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26224862
17.
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.
Hum Mol Genet
; 23(24): 6567-74, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25051958
18.
Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity.
Am J Hum Genet
; 92(2): 245-51, 2013 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23332917
19.
A direct interaction between leucine-rich repeat kinase 2 and specific ß-tubulin isoforms regulates tubulin acetylation.
J Biol Chem
; 289(2): 895-908, 2014 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24275654
20.
Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.
Hum Mol Genet
; 22(21): 4293-305, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23771029