Detalhe da pesquisa
1.
The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model.
Int J Mol Sci
; 25(3)2024 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38339158
2.
Design, synthesis, and biological evaluation of deuterated indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ agonists.
Bioorg Med Chem
; 96: 117533, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37976807
3.
Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.
Bioorg Med Chem
; 56: 116615, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051813
4.
Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.
Bioorg Chem
; 99: 103803, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32251945
5.
Metformin improved a heterologous prime-boost of dual-targeting cancer vaccines to inhibit tumor growth in a melanoma mouse model.
Int Immunopharmacol
; 128: 111431, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38244520
6.
Discovery of a structurally novel, potent, and once-weekly free fatty acid receptor 1 agonist for the treatment of diabetes.
Eur J Med Chem
; 245(Pt 1): 114883, 2023 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343410
7.
Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease.
J Med Chem
; 66(9): 6082-6104, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37079895
8.
Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen-induced hepatotoxicity.
Chem Biol Drug Des
; 99(3): 483-495, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34936214
9.
Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.
Eur J Med Chem
; 229: 114061, 2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34954593
10.
Preclinical Safety and Biodistribution in Mice Following Single-Dose Intramuscular Inoculation of Tumor DNA Vaccine by Electroporation.
Hum Gene Ther
; 33(13-14): 757-764, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35369733
11.
Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist.
Eur J Med Chem
; 211: 113106, 2021 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33360559
12.
Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome.
Eur J Med Chem
; 225: 113807, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34455359
13.
HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis.
J Pharm Pharmacol
; 72(11): 1564-1573, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32734608
14.
Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis.
Eur J Pharmacol
; 882: 173300, 2020 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32592770