Detalhe da pesquisa
1.
MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".
Mol Cell
; 82(1): 140-158.e12, 2022 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34890565
2.
Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1.
Mol Cell
; 81(24): 5007-5024.e9, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34767771
3.
Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion.
PLoS Genet
; 17(9): e1009763, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34499654
4.
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.
PLoS Pathog
; 17(9): e1009954, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34543352
5.
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood
; 129(21): 2882-2895, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283481
6.
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
Int J Cancer
; 142(10): 2139-2152, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243224
7.
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Genome Res
; 25(2): 201-12, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452314
8.
Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription.
Sci Adv
; 9(41): eadg5109, 2023 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37831776
9.
TOP1 CAD-seq: A protocol to map catalytically engaged topoisomerase 1 in human cells.
STAR Protoc
; 3(3): 101581, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35942340
10.
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner.
Cancer Res Commun
; 2(3): 182-201, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36874405
11.
Analysis of Myc Chromatin Binding by Calibrated ChIP-Seq Approach.
Methods Mol Biol
; 2318: 161-185, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34019290
12.
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Front Cell Dev Biol
; 8: 568, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719798
13.
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
Commun Biol
; 2: 39, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30701204
14.
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Cancer Discov
; 9(8): 1036-1049, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092402
15.
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
PLoS Negl Trop Dis
; 11(3): e0005432, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28263991
16.
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.
Clin Cancer Res
; 22(22): 5539-5552, 2016 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27486174
17.
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Oncotarget
; 7(31): 49800-49818, 2016 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27391441
18.
Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.
Pigment Cell Melanoma Res
; 27(4): 590-600, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24495407