Association of anxiety, age and oral health-related quality of life with periodontitis: A case-control study.

OBJECTIVE: This case-control study evaluated the association of sociodemographic profile, mental health disorders and oral health-related quality of life (OHRQoL) with periodontitis. METHODS: Patients with periodontitis (PP, n = 50) and control patients (CP, n = 50) were allocated into 2 groups after a complete periodontal examination. Data collection included age, sex, marital status, education and application of 2 questionnaires: Hospital Anxiety and Depression Scale for the diagnosis of anxiety/depression and Impact Profile on Oral Health (OHIP-14) for classification of well-being. An adjusted multiple binary logistic regression analysis was performed to assess the effect of all studied covariates on periodontitis. RESULTS: The results show that mean clinical attachment loss and periodontal probing depth were 5.92 (SD = 0.42) and 5.46 (SD = 0.78) in PP and 0.00 (SD = 0.00) and 2.85 (SD = 0.23) in CP, respectively (p < 0.001). The regression analysis demonstrated a significant effect on periodontitis for age (OR = 1.13; p < 0.0001; 95% CI: 1.07-1.20), with the PP having more people aged 50 years or older than CP, anxiety (OR = 1.25; p = 0.020; 95% CI: 1.04-1.50) and OHIP-14 (OR = 1.17; p < 0.0001; 95% CI: 1.08-1.226). CONCLUSIONS: The findings showed a positive association between anxiety, OHRQoL and age with periodontitis.

Comparative Evaluation of Homeopathic Therapy in the Treatment of Chronic Periodontitis.

CONTEXT AND OBJECTIVE: Periodontitis and type 2 diabetes (T2D) are chronic diseases generally treated with conventional therapies alone. The aim of this study was to compare the effects of homeopathy as an adjunct to conventional periodontal therapy in individuals with periodontitis and T2D. DESIGN: 85 individuals, age between 35 and 70 years, of both genders, participated in this randomized study; 70 patients were from the Institute of Endocrinology and Diabetes of Rio de Janeiro, Brazil. They were divided into 2 groups: G1, individuals with periodontitis without systemic conditions; and G-2, individuals with periodontitis and T2D. Both groups received homeopathic treatment and were evaluated in clinical and laboratory examinations. The medication used was chosen based on the similarity principle: Berberis 6CH, Mercurius Solubilis/Belladona /Hepar Sulfur and a Pyrogenium 200CH biotherapic. Medications were prescribed in diluted low ultra-diluted concentration doses for all signs and symptoms, while biotherapics were used for chronic stimulation. SETTING: The study was performed in Brazil by university research professors of homeopathy and periodontics. RESULTS: Both groups showed significant clinical and laboratory improvements during the study from baseline to 1 year with reductions in total cholesterol (total-C), triglycerides, glucose, glycated hemoglobin (A1cHb), uric acid and C-reactive protein (CRP). Statistical and descriptive analyses were performed. For most parameters, G1 performed better than G2 (P < .05). CONCLUSION: Homeopathy as an adjunct to periodontal treatment improves local and systemic clinics and can provide better health conditions for patients with or without T2D.

A comparative study between replica and cementation techniques in the evaluation of internal and marginal misfits of single crowns.

STATEMENT OF PROBLEM: Systematic reviews about the internal and marginal misfits of fixed prostheses have identified a limited number of clinical studies, suggesting the need for further research on the subject. Although the replica technique has been described as suitable for this purpose, few studies have validated it. PURPOSE: The purpose of this in vitro study was to compare the ability of a nondestructive replica technique and a destructive cementation technique to assess internal and marginal misfits of zirconia copings, considering current materials and designs. MATERIAL AND METHODS: Twelve anatomic prefabricated abutments (Neodent) were used to manufacture zirconia copings following the Ceramill (Amann Girrbach AG) (n=6) and Lava (3M ESPE) (n=6) systems. Replications of the cementation line were obtained with polyvinyl siloxane for the replica technique, and the copings were then cemented and sectioned to obtain 5 surfaces (buccal, palatal, mesial, distal, and incisal) and the linear and angle regions (internal axiogingival and axioincisal angles). The thickness of the cement line and silicone film was measured at 45 reference points on each abutment. A total of 540 measurements were made with an optical microscope with a digital camera at magnifications of ×100 and ×200. Data were analyzed by repeated-measures ANOVA and the Bonferroni multiple comparison tests (α=.05). RESULTS: In the internal misfit evaluation, the mean values observed for the cementation technique and replica technique were as follows: angle regions, 70.6 µm and 72.2 µm; linear regions, 59.1 µm and 59.6 µm; incisal surface, 139.0 µm and 139.8 µm; buccal surface, 72.4 µm and 73.8 µm; palatal surface, 73.1 µm and 75.2 µm; mesial surface, 74.1 µm and 73.8 µm; distal surface, 75.0 µm and 76.3 µm; and overall mean, 73.6 µm and 74.8 µm, respectively. In the evaluation of the marginal misfit, the mean values found were: buccal surface, 36.7 µm and 37.8 µm; palatal surface, 37.5 µm and 36.8 µm; mesial surface, 44.0 µm and 43.7 µm; and distal surface, 44.6 µm and 45.2 µm, respectively. No significant differences were found between the 2 techniques for all locations and systems (P>.05). CONCLUSIONS: Within the limitations of this in vitro study, both techniques presented the same ability to assess the internal and marginal misfits when the location and overall mean averages were evaluated (P>.05).

Role of professional expertise in the decision-making process for periodontally compromised teeth.

The objective of this study was to evaluate factors that may influence decision-making with regard to extraction or maintenance of periodontally compromised teeth. A questionnaire with 2 distinct clinical scenarios, each including a radiographic image, was provided to students in their final year of dental school and practicing dentists. The participants were asked to record the action that they would take in each case (tooth maintenance vs extraction) and provide a justification for their decision. The questionnaires were answered by 158 dental students and 57 dentists (N = 215). Among the sample as a whole, 31.16% of participants recommended extraction in scenario 1, while only 5.58% recommended that action in scenario 2. In scenario 1, there was a statistically significant difference in the recommendations of the dental students and the dentists, with the former group significantly more disposed to conservative action, that is, maintenance of the tooth (P < 0.001; chi-square test). When the actions recommended by participants specializing in implants or periodontics (or both) were compared with those recommended by other specialists, there was a statistically significant difference between the groups regarding maintenance and extraction (P = 0.012; Fisher exact test), with the former group recommending fewer extractions. When the responses were evaluated in terms of the participants' years of specialty practice, it was observed that professionals with fewer than 20 years of practice were more conservative in their decisions, choosing tooth maintenance significantly more often than specialists with longer experience (P = 0.031; Fisher exact test). Among the majority of both dental students and practicing dentists, the decision in both scenarios was to maintain the compromised teeth; however, the results suggested that that both the years of experience of the individual and the specialty of the practitioner can influence decision-making.

The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review.

The aim of this study was to assess the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) on the non-surgical periodontal treatment of residual pockets. This work was performed and reported according to the Cochrane and PRISMA recommendations, respectively, and registered at the PROSPERO registry (number CRD42017058403). An extensive search of the biomedical literature was conducted on four databases from January 1960 to August 2018, followed by hand searching. Analysis of the quality of the selected studies was based on the risk of bias. Only two randomised controlled clinical trials (RCTs) met the inclusion criteria although they had unclear risk of bias. One study showed that repeated applications of aPDT in association with conventional non-surgical treatment during periodontal maintenance improved all clinical outcomes after 6 months. The other study, which assessed the effects of repeated applications of aPDT in association with ultrasound debridement on periodontal pathogens, showed no significant reduction of the main pathogens after 3-6 months but reported reductions of probing pocket depth and C-reactive protein after 3 and 6 months, respectively, compared to mechanical therapy alone. Concluding, it was not possible to state that repeated applications of aPDT, in association with non-surgical treatment of residual pockets, have effective clinical effects in the periodontal maintenance therapy. Although one can consider that aPDT is a promising adjuvant therapy, it is still necessary to carry out more RCTs with low risk of bias in order to confirm or refute the benefits of multiple applications for residual periodontal pockets.

Dislodgment Resistance of Bioceramic and Epoxy Sealers: A Systematic Review and Meta-analysis.

OBJECTIVES: The aim of the present systematic review was to evaluate if epoxy resin-based root canal sealers present superior push-out bond strength compared to calcium silicate-based root canal sealers. METHODS: The inclusion criteria consisted of in vitro studies that compared the push-out bond strength of epoxy resin-based and calcium silicate-based sealers. A systematic search was performed in the following databases for articles published until February 2018: PubMed, ScienceDirect, Scopus, Web of Science, and OpenGrey. The quality assessment and data extraction of the selected articles were performed. A meta-analysis of the pooled data and the subgroups according to the root thirds was carried out using the RevMan software (P < .05). RESULTS: The search resulted in 2292 studies. After the duplicate studies were removed and the title and abstract were read, 20 studies were selected and 17 were considered as having a low risk of bias. The pooled meta-analysis comparing epoxy resin-based (n = 467) and paste-to-paste calcium silicate-based root canal sealers (n = 467) demonstrated higher mean push-out bond strength values (P < .001) for the epoxy resin-based root canal sealers; the heterogeneity among studies was 85% (I2). The comparisons between epoxy resin-based (n = 358) and premixed ready-to-use calcium silicate-based root canal sealers (n = 358) also demonstrated a significant difference between the sealers (P < .05), with an I2 of 95%. The subgroup analysis showed that only in the middle third, were increased bond strength values for epoxy resin-based sealer observed (P < .001), with an I2 of 94%. CONCLUSIONS: The epoxy resin-based sealer demonstratedhigher push-out bond strength than paste-to-paste calcium silicate-based root canal sealer regardless of the root third assessed. In addition, the epoxy resin-based sealer exhibited increased push-out bond strength in comparison with premixed ready-to-use calcium silicate-based root canal sealer when evaluating the middle third.

In vitro evaluation of the internal and marginal misfit of CAD/CAM zirconia copings.

STATEMENT OF PROBLEM: The constant updating of computer-aided design/computer-aided manufacture (CAD/CAM) systems and the introduction of new systems confirm the need for scientific evidence on internal and marginal adaptation. PURPOSE: The purpose of this in vitro study was to measure and compare the degree of internal and marginal misfits of zirconia single-unit copings made by using 3 different CAD/CAM systems (Ceramill, Lava 3M, and Neoshape). MATERIAL AND METHODS: Twenty-four anatomic prefabricated abutments (Neodent) were used to fabricate zirconia copings in Ceramill (n=8), Lava (n=8), and Neoshape (n=8). All copings were cemented and cut with a precision cutting machine to obtain 5 surfaces (mesial, distal, buccal, palatal, and incisal) and angle regions (internal axiogingival and axioincisal angles). Measurements were obtained from images at a magnification of ×100 and ×200 made with a digital camera attached to an optical microscope and adapted with a measuring device. The data were statistically analyzed with the 2-way ANOVA and Tukey honestly significant difference tests (α=.05). RESULTS: In the internal misfit evaluation, the mean values observed for Ceramill, Lava, and Neoshape were palatal surface 76.5, 65.5, and 77.7 µm (P=.003); angle regions 69.4, 68.6, and 74.5 µm (P=.010); incisal surface 127.7, 97.2, and 182.2 µm (P<.001); and overall mean 72.1, 69.4, and 76.4 µm (P=.003). Significant differences were not found for mesial, distal, or buccal surfaces (P>.05). In the evaluation of marginal misfit (marginal discrepancy and absolute marginal discrepancy), the mean values found were 40.9 and 65.8 µm for Ceramill, 34.2 and 70.0 µm for Lava, and 39.3 and 74.5 µm for Neoshape. No significant differences were found among the 3 systems (P>.05). CONCLUSIONS: Although the Lava system showed a significantly lower value of internal misfit than the Neoshape system, all systems showed clinically acceptable marginal misfit values.

CAD-CAM and heat-press: Comparison of internal and marginal fit of lithium disilicate copings.

The aim of this in vitro study is to compare the performance of digital and conventional methods in the manufacture of single copings in terms of the internal and marginal fit. Twenty-four prefabricated titanium Cone Morse Exact abutments of the lateral anatomical type were used to manufacture 24 lithium disilicate copings in the CAD-CAM Ceramill (n = 12) and heat-press (n = 12) systems. The copings were cemented using a self-adhesive resin cement (RelyX U-200; 3M ESPE) and then cut vertically. The cement line was photographed using an optical microscope at ×100 and ×200 magnification and then the internal and marginal regions were measured. The mean values of fits, for the CAD-CAM and heat-press techniques, respectively, were (µm): angular regions, 81.8 and 75.3; linear regions, 63.1 and 60.1; incisal regions, 171.1 and 114.7; marginal discrepancy, 74.1 and 75.2; and absolute marginal discrepancy, 99.5 and 96.2. MANOVA test showed that there is an effect of the techniques on the regions (p < .05). The effects of laboratories and the interaction between laboratories and techniques on the regions were not statistically significant (p > .05). The techniques evaluated presented clinically acceptable results for the marginal fit. However, the conventional method performed better for the internal fit. RESEARCH HIGHLIGHTS: Scientific evidence regarding the methods of making prosthesis can help the dental professional in decision-making. Digital and conventional methods is both good in the manufacture of single copings in terms of the internal and marginal fit.

Comparing the Long-Term Success Rates of Tooth Preservation and Dental Implants: A Critical Review.

Implant therapy is considered a predictable, safe, and reliable rehabilitation method for edentulous patients in most clinical scenarios. Thus, there is a growing trend in the indications for implants, which seems attributable not only to their clinical success but also to arguments such as a more "simplified approach" based on convenience or the belief that dental implants are as good as natural teeth. Therefore, the objective of this critical literature review of observational studies was to discuss the evidence concerning the long-term survival rates and treatment outcomes, comparing endodontically or periodontally treated teeth with dental implants. Altogether, the evidence suggests that the decision between keeping a tooth or replacing it with an implant should carefully consider the condition of the tooth (e.g., amount of remaining tooth and degree of attachment loss and mobility), systemic disorders, and patient preference. Although observational studies revealed high success rates and long-term survival of dental implants, failures and complications are common. For this reason, attempts should be made to first save maintainable teeth over the long-term, instead of immediately replacing teeth with dental implants.

Short Implant and Heavy Smokers as Predictors for Failure of Immediate Implants: a Retrospective Study.

Background: The possibility of installing implants in fresh sockets was first proposed as a viable treatment option in the 1970s. Objective: to assess the relationships of subject-level and implant-level characteristics on the failure of immediate implants installed in sites that contained teeth associated or not with chronic apical periodontitis. Material and Methods: A retrospective study was undertaken with data from patients who received immediate implants with a minimum follow-up of 12 months after loading. The Generalized Estimating Equation, applying a multiple logistic regression model, was employed to investigate the association between predictor variables/co-variables and failure of the immediate implants. Results: Four hundred and twenty-three implants were installed (208 uninfected/215 infected sites) in 186 patients (92 men/96 women) with a mean age of 57.1 years old. The survival rate of implants was 91%. Approximately half (215/50.8%) of the alveoli that received immediate implants had chronic apical periodontitis associated with the extracted teeth, and 191 (88.8%) of these survived until the last follow-up visit. When the infection-free sites were analyzed, this frequency was higher (93,3%), but the presence of chronic apical periodontitis did not show statistical significance in the implant failure (p=0.167). Smokers with a consumption of more than 20 cigarettes/day and short implants had more failures (OR:7.66, p=0.012; OR:14.06, p=0.002; respectively). Conclusions: Short implants and consumption of more than 20 cigarettes/day were important predictors for failure of immediate implants, regardless of presence of chronic apical periodontitis. Key words:Osseointegration, dental implant, smokers, study, immediate dental implant loading.

An in vitro study to assess glucose microleakage along fiber posts cemented with 2- and 3-step etch-and-rinse resin adhesive systems.

The aim of the study is to compare the sealing ability of two adhesive systems. Thirty teeth were endodontically treated and were randomly assigned to 2 groups: G 1 - 3-step adhesive (Solobond-Plus) and G 2 - 2-step adhesive (Solobond-M). Posts containing glass fiber were cemented using the adhesive technique recommended by the manufacturer. All samples were mounted on a glucose leakage model. A 10 microL aliquot of solution was drawn from the glass bottle using a micropipette. The samples were then analyzed in a UV-Vis spectrophotometer. The two tested adhesive systems presented a similar capacity to prevent the glucose infiltration.

Microbial profile of symptomatic pericoronitis lesions: a cross-sectional study.

OBJECTIVE: The microbial composition of pericoronitis (Pc) is still controversial; it is not yet clear if the microbial profile of these lesions is similar to the profile observed in periodontitis (Pd). Therefore, the aim of the present study was to describe the microbial profile of Pc lesions and compare it directly with that of subjects with Pd. METHODOLOGY: Subjects with Pc and Pd were selected, and subgingival biofilm samples were collected from (i) third molars with symptomatic Pc (Pc-T), (ii) contralateral third molars without Pc (Pc-C) and (iii) teeth with a probing depth >3 mm from subjects with Pd. Counts and proportions of 40 bacterial species were evaluated using a checkerboard DNA-DNA hybridization technique. RESULTS: Twenty-six patients with Pc and 18 with Pd were included in the study. In general, higher levels of microorganisms were observed in Pd. Only Actinomyces oris and Eubacterium nodatum were present in higher mean counts in the Pc-T group in comparison with the Pc-C and Pd-C groups (p<0.05). The microbiota associated with Pc-T was similar to that found in Pc-C. Sites with Pc lesions had lower proportions of red complex in comparison with the Pd sites. CONCLUSION: The microbiota of Pc is very diverse, but these lesions harbour lower levels of periodontal pathogens than Pd.

Homeopathy and Periodontal Treatment in Type II Diabetic Patients: a 1-Year Randomized Clinical Trial.

Chronic periodontitis (CP) and Diabetes mellitus type 2 (DMII) are chronic diseases usually treated by conventional practices. On the other hand, homeopathy can help to treat many different diseases. The aim of this study was to evaluate the effects of homeopathy (H) as an adjunct for non-surgical periodontal therapy (NSPT) in individuals with DMII and CP. Eighty individuals with CP and DM II, of both sexes and aged between 32 and 70 years, participated in this randomized, double-blind, placebo-controlled study. They were divided into two groups: control group (CG) and the test group (TG), and both groups received the NSPT. TG also received homeopathic therapy, including Berberis, Mercurius solubilis/Belladonna/Hepar sulphur and Pyrogenium, while CG received placebo. Clinical and laboratorial examinations were evaluated at baseline and after 1, 6 and 12 months of treatment. Both groups showed significant improvement throughout the study, for most of the parameters studied, but TG presented significative gain of CAL at 1 and 12 months compared to CG. Mean glucose and glycated hemoglobin significantly decreased in both groups after 6 and 12 months. However, there was a significantly further reduction of these parameters in TG, as compared to CG. In conclusion, homeopathy as supplement of NSPT may further improve health condition, including glycemic control, in DMII patients with CP.

Effect of clinical and laboratory techniques of cementation on the assessment of marginal and internal fit of prosthetic elements

Aim: The aim of this in vitro study was to compare machine and manual cementation of prosthetic elements by measuring internal and marginal fits. Methods: Eighteen anatomic prefabricated abutments were used to manufacture zirconia copings in the Ceramill (n=9) and Lava systems (n=9). The copings were cemented with a fluid consistency addition silicone using a machine (n=18) and manually (n=18) according to the replica technique. They were then cut in the buccal-palatal and mesial-distal directions. The film thickness was photographed using an optical microscope and measured in the internal and marginal regions. The data collected were analyzed by repeated measures ANOVA and Bonferroni's multiple comparison test (∂=.05). The Bland-Altman test was performed to evaluate the agreement between the methods. Results: In the evaluation of the internal and marginal misfits, the mean values observed for the cementation performed with the aid of a machine and manually, were as follows: angular regions, 76.7 µm and 76.2 µm; linear regions, 60.6 µm and 60.7 µm; incisal region, 144.8 µm and 145.2 µm; marginal region, 40.1 µm and 40.2 µm; and overall mean, 80.4 µm and 80.6 µm, respectively. No significant differences were found between the 2 methods, for any of regions and systems (P>.05). The Bland-Altman test showed agreement between the methods (P>.05) and that the limits of agreement found were clinically acceptable. Conclusions: Within the limitations of this in vitro study, we can conclude that cementation using manual techniques or mechanical aid produces the same cement films

¿La Entrevista Motivacional puede ser utilizada en la prevención de las caries en preescolares? Una revisión integradora / A Entrevista Motivacional pode ser utilizada na prevenção da cárie em pré-escolares? Uma revisão integrativa / Can Motivational Interviewing be used in caries prevention in preschoolers? An integrative review

El objetivo fue realizar una revisión a partir de una duda clínica: "¿La práctica de la entrevista motivacional (EM) puede ser utilizada en la prevención de las caries en preescolares?" Materiales y métodos: se realizó una revisión integradora de la literatura en abril de 2021 utilizándose una adaptación del "Sistema 6S". Se evaluó la calidad de las revisiones sistemáticas (RS). Fueron realizadas búsquedas en las revistas periódicas Evidence-Based Dentistry, Journal of Evidence-Based Dental Practice y en el sitio del Centro de Odontología Basada en Evidencias de American Dental Associaton, Biblioteca Cochrane y PubMed/Medline. Las palabras para la búsqueda fueron "motivational interviewing" y "dental caries". Resultados: Se hallaron 2 RS sobre el tema. Una RS de 2020 mostró reducción de caries a través del meta-análisis, pero sin diferencia estadísticamente significativa; los autores destacan que las evidencias limitadas se deben a la presencia de estudios heterogéneos basados en diferentes metodologías. Otra RS de 2021 concluyó que la EM posee el potencial de modificar el comportamiento y reducir significativamente lesiones cariosas principalmente en niños con elevada experiencia de caries. Fue también evaluada la calidad metodológica de las RS incluidas en esta revisión a través de los protocolos PRISMA y AMSTAR-2. Ambas presentaron bajo riesgo de sesgo y alta calidad. Conclusión: la práctica de la EM contribuyó en la prevención de la caries en preescolares, principalmente en los niños de alto riesgo. Sin embargo, las evidencias son moderadas, obtenidas a partir de meta-análisis poco robustos y de un número limitado de estudios aleatorios de buena calidad metodológica

Objetivou-se realizar uma revisão integrativa a partir de uma dúvida clínica: "A prática da entrevista motivacional (EM) pode ser utilizada na prevenção da cárie dentária em pré-escolares?". Materiais e métodos: foi realizada uma revisão integrativa da literatura em abril de 2021 utilizando-se uma adaptação do "Sistema 6S". Avaliou-se a qualidade das revisões sistemáticas (RS) encontradas através de duas ferramentas para avaliação metodológica. Foram realizadas buscas nos periódicos Evidence-Based Dentistry, Journal of Evidence-Based Dental Practice e no site do Centro de Odontologia Baseada em Evidências da American Dental Associaton. Buscou-se RS nas bases da Biblioteca Cochrane e PubMed/Medline. As palavras selecionas para as buscas foram "motivational interviewing" e "dental caries". Resultados: a busca final resultou em 2 RS sobre o tema. Uma RS de 2020 mostrou redução de cárie através da meta-análise, porém sem diferença estatisticamente significativa; os autores destacam que as evidências limitadas se devem a presença de estudos heterogêneos baseados em diferentes metodologias. Outra RS de 2021 concluiu que a EM possui o potencial de modificar o comportamento e reduzir significativamente lesões cariosas principalmente em crianças com elevada experiência de cárie. Foi ainda avaliada a qualidade metodológica das RS incluídas nesta revisão através dos protocolos PRISMA e AMSTAR-2. Ambas apresentaram baixo risco de viés e alta qualidade. Conclusão: a prática da EM contribui na prevenção da cárie em pré-escolares, principalmente nas crianças de alto risco. Entretanto, as evidências são moderadas, obtidas a partir de meta-análises pouco robustas e de um número limitado de estudos randomizados de boa qualidade metodológica

Aim: to perform an integrative review based on a clinical question: "Can motivational interviewing (MI) be used to prevent dental caries in preschool children?". Materials and methods: an integrative literature review was conducted in April 2021 using an adaptation of the "6S System". We also evaluated the quality of the systematic reviews (SR) found through two tools for methodological assessment. Evidence-Based Dentistry, Journal of Evidence-Based Dental Practice and on the website of the Center for Evidence-Based Dentistry of the American Dental Association. SRs were searched in the Cochrane Library and PubMed/Medline databases were searched. The selected search words were "motivational interviewing" and "dental caries". Results: the final search resulted in 2 SR on the topic. One SR from 2020 showed a reduction in dental caries through meta-analysis, but with no statistically significant difference; the authors point out that the limited evidence is due to the presence of heterogeneous studies based on different methodologies. Another SR from 2021 concluded that MI has the potential to modify behavior and significantly reduce carious lesions, mainly in children with high caries experience. The methodological quality of the SR included in this review was also assessed using the PRISMA and AMSTAR-2 protocols. Both showed high quality and low risk of bias. Conclusion: the practice of MI contributes to the prevention of dental caries in preschoolers, especially in high-risk children. However, the evidence is moderate, obtained from poor meta-analyses and a limited number of randomized studies of good methodological quality.

Evaluation of homeopathy effects associated with conventional periodontal therapy in randomized treatment of diabetic and non-diabetic patients with periodontitis

Periodontitis and Diabetes Mellitus type 2 (DMII) are chronic diseases treated by conventional practices and traditional medicine. In many cases, when conventional medicine cannot offer a satisfactory treatment, increases the demand for alternative therapies in chronic conditions. The aim of this study randomized was to compare and evaluate for one year clinical and serologic parameters the effects of homeopathy as an adjunct of conventional periodontal therapy in individual with periodontitis and DMII. Materials and Methods:85 individuals, of both genders, between 35 and 70 years old, participated in this randomized study, which 70 were eligible in Institute of Endocrinology and Diabetes of Rio de Janeiro-Brazil. They were divided into two groups G-1: individuals with periodontitis without systemic conditions and G-2: individuals with periodontitis and DMII. Both groups received homeopathic treatment and were evaluated in clinical and laboratorial examinations. The medication used was chosen based on the similarity principle, following the Berberis 6CH protocol (2 tablets, 2 times a day for 45 days), Mercurius Solubilis / Belladona / Hepar Sulfur-6CH (2 tablets, 3 times a day for 15 days) and a Pyrogenium 200CH biotherapeutic (single weekly dose, 2 weeks). Medications are prescribed in diluted low concentration doses for all signs and symptoms, while biotherapy is used for chronic stimulation Results:Both groups showed significant improvements throughout the study,clinical and laboratorial, at 1 year baseline: reductions in total cholesterol, triglycerides, glucose, glycated hemoglobin, uric acid and CPR. Statistical and descriptive analyzes were performed. The data obtained after laboratory analysis were tabulated and then submitted to the SPSS 17.0 software for Windows (SPSS Inc., Chicago, IL) and significance level with p <0.05. For most of parameters, G-1 performed better than G-2 (p<0.05).Conclusion:After 1 year follow-up this clinical trial suggest that homeopathy therapy, as an adjunct of periondontal treatment, improves local and systemic parameters and can provide better health condition.

Cytocompatibility of a self-adhesive gutta-percha root-filling material.

CONTEXT: A novel root-filling material based on the incorporation of ultrafine alkaline bioactive glass particles (bioactive gutta-percha, [BGP]) was developed to work without sealer. AIM: In the present study, the objective was to verify the in vitro biological response to this material by assessing its cytocompatibility. MATERIALS AND METHODS: Prototypes of BGP were compared to conventional gutta-percha (GP), dense polystyrene beads as a negative control and fragments of latex as a positive control. Extracts of each material were prepared according to ISO 10993-5:2009, and human osteoblast-like cells in primary culture were exposed to all extracts for 24 h. Cell viability was assayed sequentially for three different parameters: mitochondrial activity, membrane integrity, and cell density. STATISTICAL ANALYSIS USED: Nonparametric analysis (using Kruskal-Wallis test combined with post hoc Dunn's test) was performed for comparison among groups, with significance established at 5%. RESULTS: BGP reduced mitochondrial activity to 62% of control, but presented no toxicity on membrane integrity and proliferation assays. BGP effect on metabolism was dose-dependent and reduced to acceptable levels with dilution. CONCLUSION: The novel GP material presented slight dose-dependent effects on cell metabolism but did not affect cell survival.

Impact of well-controlled type 2 diabetes mellitus on quality of life of chronic periodontitis patients.

BACKGROUND: The purpose of the study is to examine the quality of life (QoL) in chronic periodontitis (CP) patients associated with or not with well-controlled type 2 diabetes mellitus (DM2). MATERIALS AND METHODS: Five hundred CP patients, 250 with DM2 (GDM2 group) and 250 age- and gender-matched controls without DM2 (GND), were enrolled in this cross-sectional case-controlled study from January to September 2015. They were interviewed by a QoL questionnaire (Functional Assessment of Chronic Illness Therapy-Fatigue) validated to Portuguese. Periodontal examinations were also performed to confirm CP: probing pocket depth and clinical attachment level must be >3 mm. RESULTS: An association between the presence of DM2 and a high negative impact on QoL was observed. All domains in GDM2 patients presented mean values above 19. On the other hand, three functional domains in GND (physical, social/family, and emotional) showed values below 19 (medium negative impact). Comparisons between GND and GDM2 revealed the statistical difference between them for all domains (P < 0.05). CONCLUSIONS: This study shows that DM2 associated with CP negatively affect QoL, even considering well-controlled diabetic patients.

The Impact of Tooth Whitening Procedures on the Quality of Life: a Topic Review / O Impacto na Qualidade de Vida do Procedimento de Clareamento Dental: uma Revisão Sobre o Tema

A estética em odontologia é uma das metas a ser alcançada visando à melhoria da qualidade de vida do paciente. O clareamento dental é um procedimento de baixo custo que pode ser realizado no consultório ou pelo próprio paciente em casa. Vários trabalhos científicos comprovaram sua eficácia e outros estudos foram realizados para avaliar essa eficácia com o impacto psicossocial. Entre as ferramentas que têm sido utilizadas para esse fim estão os questionários Oral Health Impact Profile (OHIP), Oral Impact on Daily Performance (OIDP) e Psicossocial Impact of Dental Esthetics (PIDAQ). O presente estudo tem como objetivo fazer uma revisão da literatura sobre o impacto do clareamento dental na qualidade de vida dos pacientes. As bases de dados PubMed, Cochrane Central, Scopus e Embase foram pesquisadas. Foram identificados 224 artigos e selecionados 40, dos quais 13 eram estudos clínicos. Parece haver um consenso na literatura pesquisada em relação ao clareamento dentário e à melhora da qualidade de vida. Por outro lado, sensibilidade dentária e irritação gengival também foram relatadas, o que pode levar a um impacto negativo na vida das pessoas. Porém, esse efeito negativo pode ser evitado ou minimizado pela associação do diagnóstico correto da mudança de cor, a utilização da técnica ideal e a concentração do agente clareador recomendada pelo dentista.

One of the goals to be achieved in cosmetic dentistry is the improvement of a patient's quality of life. Tooth whitening is a low-cost procedure that can be performed either in- office or by the patients themselves, at home. Several scientific papers have proven its effectiveness and other studies have been conducted to evaluate its psychosocial impact. Among the tools that have been used for this purpose are the questionnaires Oral Health Impact Profile (OHIP), Oral Impact on Daily Performance (OIDP) and Psycho-social Impact of Dental Aesthetics (PIDAQ). The present study aims to review the literature regarding the impact tooth whitening has on a patients' quality of life. PubMed, Cochrane Central, Scopus and Embase databases were searched. 224 articles were identified, and 40 articles were selected, of which 13 were clinical studies. There seems to be a consensus in the literature researched associating tooth whitening to improvement in quality of life. On the other hand, some negative impacts have been reported, such as dental sensitivity and gingival irritation. However, these negative effects can be minimized or even avoided with the combination of correct diagnosis of the color change, ideal technique application, and the appropriate concentration of whitening agent as recommended by the dentist.

Use of the Strength of Recommendation Taxonomy (SORT) to assess full-mouth treatments of chronic periodontitis.

Previous studies have not resolved whether scaling and root planing with a full-mouth (with or without antiseptics) or quadrant approach is better for treatment of chronic periodontitis. We identified relevant studies and used Strength of Recommendation Taxonomy (SORT) criteria to critically interpret the results of all relevant studies. A literature search was performed using the PubMed, EMBASE, and Cochrane databases up to July 2015. Selected studies were stratified according to their quality, quantity, and consistency. In total, 377 studies were identified, and 36 articles selected for retrieval were stratified according SORT criteria, as follows: no level 1 studies, 15 level 2 studies, and 21 level 3 studies (which were excluded from subsequent analysis). Among the selected level 2 studies, including seven randomized clinical trials and three systematic reviews, 67% showed no significant difference between scaling and root planing with a full-mouth or quadrant approach. In conclusion, on the basis of the best available data, the strength of evidence is grade B (consistent, low-quality evidence) for full-mouth (with or without antiseptics) and quadrant scaling and root planing for treatment of chronic periodontitis.