Detalhe da pesquisa
1.
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.
Circ Res
; 120(11): 1776-1788, 2017 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28325781
2.
The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance.
J Lipid Res
; 59(11): 2047-2062, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30154230
3.
High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.
Am J Physiol Regul Integr Comp Physiol
; 315(5): R934-R944, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30088983
4.
Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.
Diabetologia
; 60(6): 1066-1075, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28352940
5.
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
J Biol Chem
; 291(32): 16904-19, 2016 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27298316
6.
Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.
Am J Physiol Heart Circ Physiol
; 313(2): H293-H303, 2017 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28550179
7.
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
J Am Soc Nephrol
; 26(3): 597-610, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25071086
8.
The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt.
J Biol Chem
; 289(7): 4377-86, 2014 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24368771
9.
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
Am J Physiol Regul Integr Comp Physiol
; 309(1): R71-8, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25924878
10.
Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance.
Prostaglandins Other Lipid Mediat
; 120: 40-9, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25986599
11.
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
J Biol Chem
; 288(7): 5223-31, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23283969
12.
Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.
Am J Physiol Renal Physiol
; 307(4): F453-60, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24966089
13.
Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.
Clin Sci (Lond)
; 127(7): 463-74, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24707975
14.
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.
J Am Soc Nephrol
; 24(8): 1288-96, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23641057
15.
Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney.
Am J Physiol Renal Physiol
; 305(12): F1680-6, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24154693
16.
20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.
Am J Physiol Renal Physiol
; 305(5): F753-63, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23825080
17.
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
J Biol Chem
; 285(17): 12840-50, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20178979
18.
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.
Mol Cell Biol
; 27(8): 3023-34, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17283047
19.
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
J Clin Invest
; 116(6): 1696-702, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16691295
20.
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.
Arch Biochem Biophys
; 489(1-2): 82-91, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19464254