Food and non-food reinforcement among pregnant women.

Excessive gestational weight gain (GWG) in pregnancy may be driven in part by greater motivation to eat, and studying the relative reinforcing value of food versus non-food commodities may provide insight into factors important for excessive GWG. This study was a cross-sectional examination of the relationship between women meeting the Institute of Medicine (IOM) guidelines for GWG and the relative reinforcing value of food vs. non-food commodities during pregnancy. Two-hundred and thirty-three pregnant women (1st trimester, n = 44; 2nd trimester, n = 105; 3rd trimester, n = 84), aged 18-40, were recruited via a crowdsourcing platform and completed an online survey. Relative food reinforcement (RRVfood), relative non-food activity reinforcement (RRVactive) and relative non-food cognitively enriching activity reinforcement (RRVcognitive) were measured by a questionnaire at the point of contact. Self-reports of gestational age and weight gain during pregnancy were collected. The relationship between food and non-food reinforcement was assessed based on IOM classifications for weight gain during pregnancy. After adjustment for women's education level and parity, higher RRVfood (p = 0.036) and lower RRVcognitive (p = 0.040) responses were associated with greater GWG. Food reinforcing ratio (FRR) analysis was then conducted to systematically examine the effect of non-food behaviors on GWG when food reinforcement was accounted for. Women who gained below the IOM weight gain guidelines had significantly higher FRRcognitive than those gaining above (p = 0.013), indicating cognitively enriching activities may better compete with food among pregnant women. Interventions that help to increase the reinforcing value of cognitively enriching activities may be a new avenue to regulate eating to minimize GWG.

Working memory and attentional bias on reinforcing efficacy of food.

Reinforcing efficacy of food, or the relationship between food prices and purchasing, is related to obesity status and energy intake in adults. Determining how to allocate resources for food is a decision making process influenced by executive functions. Attention to appetitive cues, as well as working memory capacity, or the ability to flexibly control attention while mentally retaining information, may be important executive functions involved in food purchasing decisions. In two studies, we examined how attention bias to food and working memory capacity are related to reinforcing efficacy of both high energy-dense and low energy-dense foods. The first study examined 48 women of varying body mass index (BMI) and found that the relationship between attentional processes and reinforcing efficacy was moderated by working memory capacity. Those who avoid food cues and had high working memory capacity had the lowest reinforcing efficacy, as compared to those with low working memory capacity. Study 2 systematically replicated the methods of study 1 with assessment of maintained attention in a sample of 48 overweight/obese adults. Results showed the relationship between maintained attention to food cues and reinforcing efficacy was moderated by working memory capacity. Those with a maintained attention to food and high working memory capacity had higher reinforcing efficacy than low working memory capacity individuals. These studies suggest working memory capacity moderated the relationship between different aspects of attention and food reinforcement. Understanding how decision making process are involved in reinforcing efficacy may help to identify future intervention targets.

Taste and food reinforcement in non-overweight youth.

Food reinforcement is related to increased energy intake, cross-sectionally related to obesity and prospectively related to weight gain in children, adolescents and adults. There is very limited research on how different characteristics of food are related to food reinforcement, and none on how foods from different taste categories (sweet, savory, salty) are related to food reinforcement. We tested differences in food reinforcement for favorite foods in these categories and used a reinforcing value questionnaire to assess how food reinforcement was related to energy intake in 198 non-overweight 8- to 12-year-old children. Results showed stronger food reinforcement for sweet foods in comparison to savory or salty foods. In multiple regression models, controlling for child sex, minority status and age, average reinforcing value was related to total energy and fat intake, and reinforcing value of savory foods was related to total energy and fat intake. Factor analysis showed one factor, the motivation to eat, rather than separate factors based on different taste categories. Liking ratings were unrelated to total energy intake. These results suggest that while there are differences in the reinforcing value of food by taste groups, there are no strong differences in the relationship between reinforcing value of food by taste groups and energy or macronutrient intake.

An acute social stressor decreases reinforcing value of both high and low energy-dense food in college students in a randomized controlled trial.

It is well known that a large portion of the population elevates their intake of high energy-dense foods during times of stress; however, it is understudied whether stress affects the reinforcing value of a food reward. Further knowledge of this relationship may help us better understand the positive correlation between reinforcing value of food and obesity. Therefore, it was tested if an acute stressor would increase the reinforcing value of low or high energy-dense food. Participants (N = 70) were randomized to a stress or no-stress condition after which they were allowed to work to gain access to a food reward and reading time. To determine if high energy-dense food was specifically affected, half the participants from each stress manipulation were randomly assigned to work for either grapes or chocolate candies. Participants in the stress condition worked less for food access than those in the no-stress condition, for both low and high energy-dense foods, but stress did not affect the reinforcing value of reading time. These results indicate that, contrary to our hypothesis, in a sample of college students, an acute stressor decreased reinforcing value of food, with no difference between a low and high energy-dense food item.

Effects of Episodic Memory Recall on Reinforcing Value of Physical Activity.

OBJECTIVE: Many people prefer a sedentary versus an active lifestyle and have difficulty completing sufficient physical activity to improve health. While exercise can be a powerful reinforcer for some people, many prefer to be sedentary. The relative reinforcing value of physical activity (RRVPA) is influenced by a person's learning history with positive experiences strengthening the motivation to be active. Episodic memories may be critical to determining RRVPA, or RRV of different types of positive behaviors. METHOD: As a potential way to increase RRVPA we examined if recalling a positive episodic memory would affect RRVPA. One hundred and thirty seven adult participants completed measures of reinforcement history and memory functions and then recalled a single positive episode of either a physical activity or of a cognitively enriching activity, rated subjective memory qualities, and completed tasks to measure the RRV of both types of activity. RESULTS: Recalling a positive episodic memory increased RRV for the respective activity, and changes in RRVPA were moderated by how much the memory satisfies a basic psychological need. CONCLUSIONS: This research demonstrates the impact of episodic memory on RRVPA, which could be leveraged to aid behavior change efforts.

Reinforcing value of food, enriched home environment, and changes in percent overweight in children.

OBJECTIVE: The decision to eat is often a choice made in the context of food and non-food alternatives. However, no research, to the authors' knowledge, has assessed the combination of the motivation to eat, as indexed by the relative reinforcing value of food (RRVFOOD ), and the enriched home environment, i.e., access to activities that can serve as alternatives to eating on weight gain. METHODS: This study used a cross-sectional design to study how RRVFOOD and the enriched home environment predict percent overweight change over 2 years in 291 children aged 6 to 9 years and of varying socioeconomic status. RESULTS: Results showed that RRVFOOD and access to food were positively associated with baseline percent overweight, and an enriched home environment was negatively related to baseline percent overweight. RRVFOOD and an enriched home environment interacted to predict change in percent overweight. Children with a high relative RRVFOOD and a relatively non-enriched environment showed the greatest relative weight gain. CONCLUSIONS: These results suggest that providing an enriched home environment may reduce the effects of food reinforcement and being motivated to eat on weight gain in childhood, and this represents a novel approach to intervention that can be used to strengthen current behavioral approaches to prevent obesity in children.

Food reinforcement and obesity. Psychological moderators.

The relative reinforcing value of food (RRV(food)) provides an index of the motivation to eat. Research has shown that RRV(food) is higher in obese individuals than their non-obese peers, is associated with greater energy intake, predicts weight gain and interacts with impulsivity to predict energy intake. This study was designed to determine whether dietary restraint, dietary disinhibition or hunger moderate the effect of RRV(food) on the weight status and energy intake in 273 adults of various body mass index (BMI) levels. Hierarchical regression was used to assess the independent effects of RRV(food) on BMI and energy intake, controlling for age, sex, income, education, minority status, and RRV(reading). Results showed that greater RRV(food), but not RRV(reading), was associated with greater BMI and energy intake. Dietary disinhibition and dietary restraint moderated the relationship between RRV(food) and BMI, with dietary disinhibition being a stronger moderator of this relationship (r(2)=0.20) than dietary restraint (r(2)=0.095). In addition, dietary disinhibition moderated the effect of RRV(food) on energy intake. These results replicate the importance of RRV(food) as a predictor of obesity, and show that psychological factors moderate the effect of food reinforcement on body weight and energy intake. This trial was registered at clinicaltrials.gov as NCT00962117.

Reducing relative food reinforcement of infants using a music enrichment program: a randomized, controlled trial.

BACKGROUND: Food reinforcement or one's motivation to eat may be established early in life; it might not be the food reinforcement per se that drives weight gain, but rather the imbalance between food and nonfood reinforcement. OBJECTIVES: We implemented a 2-y randomized, controlled trial to assess the effects of a music enrichment program (music, n = 45) compared with an active play date control (control, n = 45) in 9- to 15-mo-old healthy infants who were strongly motivated to eat. METHODS: The 12-mo intensive intervention phase included 4 semesters of Music Together® or a play date program (Winter, Spring, Summer, and Fall), comprised of once per week group meetings, followed by a 12-mo maintenance phase with monthly meetings. Parents were encouraged to listen to the Music Together® program CD or play with the play date group's toy with their infants at home, respectively. We performed a modified intention-to-treat analysis using all randomly assigned, non-excluded subjects for the outcome measures [relative reinforcing value of food (RRVfood), food reinforcement, music reinforcement, and weight-for-length z-score (WLZ)]. RESULTS: There were significant differential group changes across time for RRVfood (group × month; P = 0.016; Cohen's f2 = 0.034). The music group had significantly greater RRVfood decreases than the control group from baseline to the end of the intensive intervention phase (music change = -0.211; control change = -0.015; P = 0.002; Cohen's D = 0.379). However, these differences were not maintained during months 12-24 (music change = -0.187; control change = -0.143; P = 0.448; D = 0.087). We observed an overall moderation effect by sex for food reinforcement and WLZ. Boys in the music group had a significant attenuation in food reinforcement and WLZ compared with boys in the control group. CONCLUSIONS: This study extends our knowledge in infant eating behavior by providing insight into the role of nonfood alternatives in altering one's motivation to eat. There may be sex differences in altering one's motivation to eat.This trial was registered at clinicaltrials.gov as NCT02936284.

Food reinforcement and habituation to food are processes related to initiation and cessation of eating.

An individual bout of eating involves cues to start eating, as well as cues to terminate eating. One process that determines initiation of eating is food reinforcement. Foods with high reinforcing value are also likely to be consumed in greater quantities. Research suggests both cross-sectional and prospective relationships between food reinforcement and obesity, food reinforcement is positively related to energy intake, and energy intake mediates the relationship between food reinforcement and obesity. A process related to cessation of eating is habituation. Habituation is a general behavioral process that describes a reduction in physiological or affective response to a stimulus, or a reduction in the behavioral responding to obtain a stimulus. Repeated exposure to the same food during a meal can result in habituation to that food and a reduction in consumption. Habituation is also cross-sectionally and prospectively related to body weight, as people who habituate slower consume more in a meal and are more overweight. Research from our laboratory has shown that these two processes independently influence eating, as they can account for almost 60% of the variance in ad libitum intake. In addition, habituation phenotypes show reliable relationships with reinforcing value, such that people who habituate faster also find food less reinforcing. Developing a better understanding of cues to start and stop eating is fundamental to understanding how to modify eating behavior. An overview of research on food reinforcement, habituation and food intake for people with a range of weight status and without eating disorders is provided, and ideas about integrating these two processes that are related to initiation and termination of a bout of eating are discussed.

Written or drawn episodic future thinking cues improves delay discounting in adults.

Delay discounting (DD) describes choices between small, immediate rewards and larger, delayed rewards. Individuals who are high in DD favor small, immediate rewards, and this preference is related to health behaviors including higher energy intake, smoking and less physical activity. Episodic future thinking (EFT) is an intervention in which one thinks about personal positive future events and this decreases DD in adults and children. In previous studies episodic events have been presented as written or auditory cues. Episodic future images are also imagined visually, but the impact of personal visual cues has not been tested. Research examining sensory modality and semantic memory has shown drawn items are associated with better recall than writing or viewing provided images. This study compared drawn versus written episodic future or recent cues on DD. Sixty-nine adults were randomized to one of three groups; EFT-written, EFT-drawn or Episodic recent thinking (ERT)-written cues, and completed a computerized adjusting amount DD task cued with episodic events. Results showed both written and drawn EFT cues had a larger effect on DD than ERT-written cues and individual differences in immediate time perspective moderated this effect. This suggests that drawn and written cues can have similar effects on DD, providing future clinical work flexibility in how to present cues in the field. In addition, presenting drawn cues may improve DD for individuals who have an immediate time perspective.

Reinforcer pathology's alternative reinforcer hypothesis: A preliminary examination.

BACKGROUND AND OBJECTIVE: The novel theory of Reinforcer Pathology states that the temporal window of integration, measured by delay discounting (DD), determines the value of reinforcers. Based on the Reinforcer Pathology theory, the valuation of alternative reinforcers is positively associated with the length of the temporal window (negatively with rates of discounting). The objective of this article is to test the Reinforcer Pathology theory by reanalyzing data from a prior report (Carr & Epstein, 2018) in order to examine the association between the reinforcing value of alternative reinforcement and the length of the measured temporal window. METHOD: Participants (N = 250) who completed an adjusting delay discounting task and the Pleasant Events Schedule (PES) were included in the study. PES provides a measurement of a reinforcement score (a cross-product of PES measures of frequency and pleasantness) for 45 noneating alternative activities. Analysis of Variance and Spearman product-moment correlations were completed. RESULTS: Delay discounting was significantly positively correlated with sedentary reinforcement and significantly negatively correlated with cognitively enriching activities. A significant interaction was observed in the preference for between food and cognitive-enriching context as a function ln(k) in predicting the cognitive-enriching activity class. Nonsignificant relationships were also observed with the correlation of delay discounting to the reinforcement of social and physical activities. CONCLUSIONS: These findings provide initial support for Reinforcer Pathology theory and indicate that the temporal window over which reinforcers are integrated may be a factor contributing to a preference for some healthy or unhealthy alternative reinforcers. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The enriched home environment and dietary intake are related to percent overBMI in children.

Longitudinal research suggests that living in a cognitively enriched home environment, in which access to activities including hobbies and books are plentiful, can prevent excess weight gain and obesity in children. In order for the enriched home environment to influence weight it should influence energy and macronutrient intake and/or energy expenditure. To test this hypothesis, we used a cross sectional design to study aspects of the child's enriched home environment along with energy and macronutrient intake. A sample of 158 6-9-year-old children measured between February 2017 - April 2019 in Buffalo, NY were selected from a larger study based on criteria for accurate reporting of energy intake using the Block Kid's Food Frequency Questionnaire. Results showed that the Home Observation for Measurement of the Environment (HOME) subscales enriched environment, parental warmth and an integrated family structure were negatively related to child percent overBMI. Hierarchical regression showed that each of these factors improved variance in child percent overBMI accounted for beyond dietary intake or macronutrients, specifically accounting for a total of 18.2% variance in models controlling for total energy intake. These results provide the first demonstration that characteristics of a child's home environment are associated with lower energy intake and independently associated with percent overBMI beyond knowledge of diet. Enriching a child's home environment by providing alternative activities to eating, improving parental warmth and providing opportunities for parents to interact positively with their children may be novel ways to reduce childhood obesity that should be experimentally tested in future research.

Choice is relative: Reinforcing value of food and activity in obesity treatment.

Persons with obesity find high-energy-dense food and sedentary behaviors highly reinforcing. Diets and exercise programs deprive individuals of many favorite foods and activities, which can counterproductively heighten their value and lead to relapse. Since the value of reinforcers depend on the alternatives available, one approach to reducing food and sedentary activity reinforcement is to build healthy alternative reinforcers. Current behavioral treatment programs for children and adults do not attempt to build alternative reinforcers as substitutes for unhealthy behaviors to reduce the impact of food or activity deprivation on the motivation to eat or be inactive. A goal of the next generation of obesity treatment programs should focus on development of healthy behaviors as reinforcers so that people will be motivated to engage in them. This article provides an overview of relationships among reinforcers, how understanding substitutes and complements can influence eating and activity, and how enriching a person's environment and providing choice architecture can enhance weight control. Ideas for translation of these basic behavioral economic principles to obesity treatment programs are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

High reinforcing value of food is related to slow habituation to food.

BACKGROUND: The rate of habituation to food and reinforcing value of food are processes that are related to food intake and body weight. Reinforcing value of food provides an index of the motivation to eat, while habituation provides an index on how repeated presentations of food relate to reduced behavioral and physiological responses to that food. OBJECTIVE: To investigate the relationship between habituation phenotypes to salty, sweet and savory foods and reinforcing value of those foods. DESIGN: A sample of 229 8-12-year-old children at risk for obesity completed reinforcing value and habituation tasks for foods that varied in savory, sweet or salty tastes. Multivariate Group Based Trajectory Modeling was used to create four unique patterns of habitation to foods based on detailed 10 s epochs of responding for food over a 24 min task. Differences in reinforcing value of food were assessed for these habituation phenotypes. RESULTS: Results showed a graded relationship between the overall habituation phenotypes and reinforcing value of food, as those with the relatively flat habituation phenotype found food more reinforcing than those with phenotypes that showed rapidly decelerating responding across all taste categories. CONCLUSIONS: Those who habituated slower found food more reinforcing than those with a rapid habituation phenotype. Implications of these phenotypes for understanding how habituation relates to food intake are discussed.

Influence of sedentary, social, and physical alternatives on food reinforcement.

OBJECTIVE: This study examined the potential for nonfood alternative activities to compete with the reinforcing value of food. Participants rated the frequency and pleasantness of engaging in a variety of activities and made hypothetical choices between food and 4 types of alternatives; cognitive-enriching (reading, listening to music), social (attending a party or event), sedentary (watching TV), and physically active (running, biking). METHOD: Two-hundred seventy-six adults completed an online survey using a crowdsourcing platform. RESULTS: Adults with higher BMI reported engaging in fewer activities within the cognitive-enriching, social, and physically active categories. When examining how well each alternative activity type was able to compete with food, sedentary alternatives were associated with the highest food reinforcement, or were least able to compete with food reinforcers, as compared with cognitive-enriching, social, and physical. Social activities were associated with the lowest food reinforcement, or the best able to compete with food reinforcers. CONCLUSION: These results suggest that increasing the frequency and range of nonfood alternative activities may be important to obesity. This study also suggests that the class of social activities may have the biggest impact on reducing food reinforcement, and the class of sedentary may have the smallest effect on food reinforcement. These tools have relevance to clinical interventions that capitalize on increasing access to behaviors that can reduce the motivation to eat in clinical interventions for obesity. (PsycINFO Database Record

Reinforcing value and hypothetical behavioral economic demand for food and their relation to BMI.

Food is a primary reinforcer, and food reinforcement is related to obesity. The reinforcing value of food can be measured by establishing how hard someone will work to get food on progressive-ratio schedules. An alternative way to measure food reinforcement is a hypothetical purchase task which creates behavioral economic demand curves. This paper studies whether reinforcing value and hypothetical behavioral demand approaches are assessing the same or unique aspects of food reinforcement for low (LED) and high (HED) energy density foods using a combination of analytic approaches in females of varying BMI. Results showed absolute reinforcing value for LED and HED foods and relative reinforcing value were related to demand intensity (r's = 0.20-0.30, p's < 0.01), and demand elasticity (r's = 0.17-0.22, p's < 0.05). Correlations between demographic, BMI and restraint, disinhibition and hunger variables with the two measures of food reinforcement were different. Finally, the two measures provided unique contributions to predicting BMI. Potential reasons for differences between the reinforcing value and hypothetical purchase tasks were actual responding versus hypothetical purchasing, choice of reinforcers versus purchasing of individual foods in the demand task, and the differential role of effort in the two tasks. Examples of how a better understanding of food reinforcement may be useful to prevent or treat obesity are discussed, including engaging in alternative non-food reinforcers as substitutes for food, such as crafts or socializing in a non-food environment, and reducing the value of immediate food reinforcers by episodic future thinking.

Social reinforcement as alternative to sucrose reinforcement is increased by nicotine and methylphenidate in male Fischer-344 rats.

BACKGROUND: Stimulant drugs such as nicotine (NIC) and methylphenidate (MPH) are hypothesized to increase the reinforcing value of sensory stimuli, thus increasing the effectiveness of such reinforcers as alternatives to sucrose reinforcers. METHODS: Inbred Fischer-344 rats (n = 30) were assigned to three groups: saline (SAL; n = 10), nicotine (NIC; n = 10), or methylphenidate (MPH; n = 10). Testing was done in three phases: sucrose only, (SUC), sucrose and drug (SUC/DRUG), and sucrose, drug, and social reinforcement (SUC/DRUG/SOC). During the SUC phase, rats were trained on a progressive ratio 5 (PR5) reinforcement schedule for sucrose (20% solution). In the SUC/DRUG phase, animals were treated with SAL, NIC (0.4 mg/kg, n = 10 SC), or MPH (2.0 mg/kg, n = 10 IP) 30 min prior to testing. In the SUC/DRUG/SOC phase, animals continued receiving drug treatment, and social reinforcement was introduced concurrently with the sucrose reinforcer. The progressive ratio for each reinforcer ran independently of the others. Reinforcing value was measured as break point (BP), the highest number of responses resulting in a reinforcer. RESULTS: SAL-treated animals showed no significant change in sucrose BP. MPH-treated animals showed decreased sucrose BP in the SUC/DRUG phase, with a further reduction in the SUC/DRUG/SOC phase. NIC-treated animals decreased sucrose BP only when a social alternative was offered. CONCLUSION: Both NIC and MPH reduce the sucrose BP in the presence of a social alternative. The decrease in sucrose responding, coupled with increased social responding, suggests that the social alternative acted as an effective alternative reinforcer to sucrose. From a translational perspective, these results suggest that stimulant drugs such as NIC and MPH may increase the effectiveness of treatments that use alternative social reinforcers to decrease eating.

Food reinforcement, dietary disinhibition and weight gain in nonobese adults.

OBJECTIVE: Food reinforcement is cross-sectionally related to BMI and energy intake in adults, and prospectively predicts weight gain in children, but there has not been any research studying food reinforcement as a predictor of adult weight gain. DESIGN AND METHODS: This study examined whether the relative reinforcing value of food versus sedentary activities, as measured on a progressive ratio schedule, predicts 12-month weight gain in a sample of 115 nonobese (BMI < 30) adults. Dietary disinhibition and dietary restraint were also examined as potential moderators of this relationship. RESULTS: In a hierarchical regression controlling for baseline age and weight, dietary hunger, income, sex, and minority status, food reinforcement and predicted weight gain (P = 0.01) significantly increased the variance from 6.3% to 11.7% (P = 0.01). Dietary disinhibition moderated this relationship (P = 0.02) and increased the variance an additional 4.7% (P = 0.02), such that individuals with high food reinforcement had greater weight gain if they were also high in disinhibition. CONCLUSIONS: These results suggest that food reinforcement is a significant contributor to weight change over time, and food reinforcement may have the biggest effect on those who are most responsive to food cues.

Women who are motivated to eat and discount the future are more obese.

OBJECTIVE: Food reinforcement and delay discounting (DD) independently predict body mass index (BMI), but there is no research studying whether these variables interact to improve prediction of BMI. METHODS: BMI, the relative reinforcing value of high (PMAXHED ) and low (PMAXLED ) energy dense food, and DD for $10 and $100 future rewards (DD10 , DD100 ) were measured in 199 adult females. RESULTS: PMAXHED (P = 0.017), DD10 (P = 0.003), and DD100 (P = 0.003) were independent predictors of BMI. The interaction of PMAXLED × DD10 (P = 0.033) and DD100 (P = 0.039), and PMAXHED × DD10 (P = 0.038) and DD100 (P = 0.045) increased the variance accounted for predicting BMI beyond the base model controlling for age, education, minority status, disinhibition, and dietary restraint. Based on the regression model, BMI differed by about 2 BMI units for low versus high food reinforcement, by about 3 BMI units for low versus high DD, and by about 4 BMI units for those high in PMAXHED , but low in DD versus high in PMAXHED and high in DD. CONCLUSION: Reducing DD may help prevent obesity and improve treatment of obesity in those who are high in food reinforcement.

FTO polymorphisms moderate the association of food reinforcement with energy intake.

Food reinforcement (RRVfood) is related to increased energy intake, cross-sectionally related to obesity, and prospectively related to weight gain. The fat mass and obesity-associated (FTO) gene is related to elevated body mass index and increased energy intake. The primary purpose of the current study was to determine whether any of 68 FTO single nucleotide polymorphisms (SNPs) or a FTO risk score moderate the association between food reinforcement and energy or macronutrient intake. Energy and macronutrient intake was measured using a laboratory ad libitum snack food consumption task in 237 adults of varying BMI. Controlling for BMI, the relative reinforcing value of reading (RRVreading) and proportion of African ancestry, RRVfood predicted 14.2% of the variance in energy intake, as well as predicted carbohydrate, fat, protein and sugar intake. In individual analyses, six FTO SNPs (rs12921970, rs9936768, rs12446047, rs7199716, rs8049933 and rs11076022, spanning approximately 251kbp) moderated the relationship between RRVfood and energy intake to predict an additional 4.9-7.4% of variance in energy intake. We created an FTO risk score based on 5 FTO SNPs (rs9939609, rs8050136, rs3751812, rs1421085, and rs1121980) that are related to BMI in multiple studies. The FTO risk score did not increase variance accounted for beyond individual FTO SNPs. rs12921970 and rs12446047 served as moderators of the relationship between RRVfood and carbohydrate, fat, protein, and sugar intake. This study shows for the first time that the relationship between RRVfood and energy intake is moderated by FTO SNPs. Research is needed to understand how these processes interact to predict energy and macronutrient intake.