Neighborhood food environment and consumption of fruit and leafy vegetables: Pro-Saude Study, Brazil.

OBJECTIVE: To explore the relationship between availability of different types of retail food stores and consumption of fruit and leafy vegetables. STUDY DESIGN: This study is a cross-sectional study. METHODS: Data were derived from 2032 adults living in the city of Rio de Janeiro, Brazil, participating in the longitudinal Pro-Saude Study. Exposure to street markets, fruit and vegetable stores, groceries and markets, unhealthy food outlets, restaurants, and supermarkets within 1600 m buffers was obtained by georeferencing residential addresses. Consumption of fruit and leafy vegetables was assessed via two single questions, categorized as 'yes' (≥4 days/week) and 'no' (<3 days/week). Multiple logistic regression models were used to assess relationships of interest adjusted for surrounding average monthly income, sex, age, education, and family income per capita. RESULTS: Except for supermarkets, the presence of a greater number of retail food stores - irrespective of the type - was associated with higher odds of consumption of fruit and leafy vegetables than with areas with a lower number (e.g. odds ratio = 1.47; 95% confidence interval = 1.13-1.91). CONCLUSIONS: The greater availability of several types of retail food stores close to participants' residences was associated with higher consumption of fruit and leafy vegetables in Rio de Janeiro.

The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition.

Nystatin (Nys) is a pore forming broad-spectrum and efficient antifungal drug with significant toxicity in mammalian organisms. In order to develop a non-toxic and more effective Nys formulation, its molecular mechanism of action at the cell membrane needs to be better understood. It is widely accepted that Nys activity and toxicity depend on the presence and type of membrane sterols. Taking advantage of multiple biophysical methodologies, we now show that the formation and stabilization of Nys aqueous pores, which are associated with Nys cytotoxicity, occur in the absence of membrane sterols. Our results suggest that the Nys mechanism of action is driven by the presence of highly ordered membrane domains capable of stabilizing the Nys oligomers. Moreover, Nys pore formation is accompanied by strong Nys-induced membrane reorganization that depends on membrane lipid composition and seems to underlie the Nys cytotoxic effect. Accordingly, in membranes enriched in a gel-phase forming phospholipid, Nys incorporates within the phospholipid-enriched gel domains, where it forms pores able to expand the gel domains. In contrast, in membranes enriched in gel domain forming sphingolipids, Nys-induced pore formation occurs through the destabilization of the gel phase. These results show that the Nys mechanism of action is complex and not only dependent on membrane sterols, and provide further insight into the molecular details governing Nys activity and toxicity.

[Nutritional surveillance and morbidity of children under 5 years of age seen in a primary health care unit: historical series 1987-91]. / Vigilância nutricional e morbidade de crianças menores de 5 anos numa unidade básica de saúde: análise da série histórica 1987-91.

This paper presents preliminary analysis of the nutritional status assessment (NS) and morbidity of low-income children under 5 years of age seen by the Food and Nutritional Surveillance System of a primary health care unit in Rio de Janeiro between 1987 and 1991. The distribution of lengh/stature for age (LSA) was skewed to the left as early as the first semester of life. Approximately 20% of the children had values of body mass for age (BMA) below the 10th percentile of the reference growth curve (NCHS). The prevalence of stunting (Z LSA < - 2) decreased yearly during the period. The eight most frequent causes of visit to the unit were the same but the frequencies varied from year to year. In the last three years upper respiratory (URD) and digestive diseases (DD) and undernutrition prevailed. NS did not correlate with UPD but the prevalence of DD was inversely associated with BMA percentile. These data indicate relevant growth deficits in the children which justifies the implementation of nutritional surveillance in health units. It is also clear that morbidity and NS must be correlated in future studies, so that, the role of nutritional surveillance is enhanced in the Health Sector.

[On the plan to combat hunger and misery]. / Considerações sobre o plano de combate à fome e à miséria.

This paper discusses the "Plan Against Hunger and Misery" as it relates to the Ministry of Health. The Plan centers around the program "Milk is Health", subsidized by the Brazilian Nutritional Surveillance System and aimed at undernourished children, his/her close relatives and pregnant women under nutritional risks identified in the public health sector. The authors raise questions regarding the role(s) to be played by the health system and by the Nutritional Surveillance System in the implementation of the Plan, the guidelines for food distribution, the indicators for selecting target groups and the parameters for evaluating the program "Milk is Health" itself. It is also argued that the Plan should value structural modifications, without which it will not be possible to ameliorate misery and hunger in Brazil.

[Distribution of body mass indices of a Brazilian population under 25 years of age]. / Distribuição dos valores do índice de massa corporal da população brasileira até 25 anos.

This paper presents the percentage distribution of the body mass index of the Brazilian population from birth to age 25, based on a national survey conducted in 1989. Survey data show that body mass index decreases from birth until around 6 years of age, reaching a plateau at 8 years and progressively increasing until the age of 19 or 20 years for females and 20 or 21 for males. The survey also revealed that after the age of 12 females present a greater body mass index than males, as well as a larger range of percentile values (from 3 to 97). A comparison with data from other countries showed that the body mass index profile in Brazil is similar to that observed in France, Great Britain, and the United States. Before the age of 6, Brazilian youngsters have a mean body mass index that resembles that of North American children, and a lower one thereafter. A comparison between the median body mass index of Brazilian and British youngsters revealed consistently lower values among Brazilian females. When compared to that of France, Brazil's male population has a systematically lower body mass index after the age of 8. It is suggested that the data presented in our study be used only for comparing groups of individuals and studies, and not for screening or clinical monitoring, due to the great variability in growth patterns during adolescence.