Detalhe da pesquisa
1.
An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration.
Biomacromolecules
; 18(9): 2866-2875, 2017 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28731677
2.
Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab' Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity.
Mol Pharm
; 13(4): 1229-41, 2016 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26871003
3.
A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep.
Pharm Res
; 33(2): 510-25, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26486513
4.
PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.
Mol Pharm
; 12(3): 794-809, 2015 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25644368
5.
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.
Mol Pharm
; 12(2): 432-43, 2015 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25485615
6.
Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin.
J Biol Chem
; 287(49): 41152-64, 2012 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23024363
7.
The minimal active structure of human relaxin-2.
J Biol Chem
; 286(43): 37555-65, 2011 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21878627
8.
Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone.
Biochem Biophys Res Commun
; 420(2): 253-6, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22425984
9.
Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins.
Int J Pharm
; 608: 121075, 2021 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481889
10.
A 30â¯kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats.
Eur J Pharm Biopharm
; 137: 218-226, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30851352
11.
Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administration.
J Pharm Sci
; 104(4): 1421-30, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631360
12.
Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization.
Front Chem
; 1: 30, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24790958