1.
Bioorg Med Chem Lett
; 14(22): 5481-4, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15482908
RESUMO
Structure-activity relationship studies focused on bio-isosteric replacements of 2-pyridyl resulted in mGlu5 receptor antagonists with reduced inhibition of cytochrome P450 1A2. This led to highly potent, selective and orally bioavailable 2-imidazolyl tetrazoles such as (10) that are devoid of cytochrome P450 inhibitory activity.