Detalhe da pesquisa
1.
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Mol Cell
; 79(3): 390-405.e7, 2020 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32619402
2.
Low-latency gravitational wave alert products and their performance at the time of the fourth LIGO-Virgo-KAGRA observing run.
Proc Natl Acad Sci U S A
; 121(18): e2316474121, 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38652749
3.
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
PLoS Biol
; 20(2): e3001427, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35192607
4.
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35217606
5.
Comprehensive characterization and preclinical assessment of an imidazopyridine-based anticancer lead molecule.
Drug Dev Res
; 85(1): e22139, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084651
6.
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.
Biochem J
; 479(18): 1941-1965, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040231
7.
Conformational plasticity of the ULK3 kinase domain.
Biochem J
; 478(14): 2811-2823, 2021 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34190988
8.
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Biochem J
; 478(3): 553-578, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459343
9.
Lessons from LIMK1 enzymology and their impact on inhibitor design.
Biochem J
; 476(21): 3197-3209, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31652302
10.
Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.
J Biol Chem
; 290(26): 16415-30, 2015 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979334
11.
Influence of Arrestin on the Photodecay of Bovine Rhodopsin.
Angew Chem Int Ed Engl
; 54(46): 13555-60, 2015 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26383645
12.
Design of photocaged puromycin for nascent polypeptide release and spatiotemporal monitoring of translation.
Angew Chem Int Ed Engl
; 54(12): 3717-21, 2015 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25656536
13.
Characterization of the simultaneous decay kinetics of metarhodopsin states II and III in rhodopsin by solution-state NMR spectroscopy.
Angew Chem Int Ed Engl
; 53(8): 2078-84, 2014 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24505031
14.
Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer.
J Med Chem
; 67(5): 3339-3357, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38408027
15.
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Eur J Med Chem
; 271: 116391, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38669909
16.
Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle.
Curr Drug Targets
; 24(6): 464-483, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36998144
17.
PROTACting the kinome with covalent warheads.
Drug Discov Today
; 28(1): 103417, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306996
18.
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sci Adv
; 9(48): eadk6191, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38039358
19.
Structure of LRRK1 and mechanisms of autoinhibition and activation.
Nat Struct Mol Biol
; 30(11): 1735-1745, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37857821
20.
Structural Aspects of LIMK Regulation and Pharmacology.
Cells
; 11(1)2022 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35011704