[Advances in application of Jurkat cell model in research on infectious diseases].

Infectious diseases can be caused by multiple pathogens, which can produce specific immune response in human body. The immune response produced by T cells is cellular immunity, which plays an important role in the anti-infection process of human body, and can participate in immunological protection and cause immunopathology. The outcome of various infectious diseases is closely related to cellular immune function, especially the function of T cells. Jurkat cells belong to the human acute T lymphocyte leukemia cell line. Jurkat cell model can simulate the function T lymphocytes, so it is widely used in the in vitro studies of T cell signal transduction, cytokines, and receptor expression, and can provide reference and guidance for the treatment of various infectious diseases and the research on their pathogenesis. The Jurkat cell model has been widely used in the in vitro studies of viral diseases and atypical pathogens, but parasitic infection studies using the Jurkat cell model are still rare. This article reviews advances in the application of Jurkat cell model in the research on infectious diseases.

Long-Period Fiber Grating Sensor Based on a Conductive Polymer Functional Layer.

A temperature sensor was fabricated with a functional conductive poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coating on a long-period fiber grating (LPFG). The LPFG was fabricated by laser-assisted wet-chemical etching for controlling the grating depth of the LPFG after the treated surface of an optical fiber was inscribed by laser light. The functional conductive polymer acts as a temperature sustained sensing layer and enhances the grating depth of the LPFG sensor as a strain buffer at various temperatures. The sensor was subjected to three cycles of temperature measurement to investigate the sensor's wavelength shift and energy loss when exposed to temperatures between 30 and 100 °C. Results showed that the sensor's average wavelength sensitivity and its linearity were 0.052 nm/°C and 99%, respectively; average transmission sensitivity and linearity were 0.048 (dB/°C) and 95%, respectively.