Detalhe da pesquisa
1.
Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma.
Mol Ther
; 30(12): 3542-3551, 2022 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36242517
2.
Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.
Blood
; 135(21): 1899-1911, 2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32128578
3.
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
FASEB J
; 33(1): 652-667, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30028636
4.
A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.
J Neurosci
; 35(21): 8091-106, 2015 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26019327
5.
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
Proc Natl Acad Sci U S A
; 110(2): 642-7, 2013 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23267081
6.
Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice.
J Lipid Res
; 56(4): 848-58, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25722343
7.
Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.
J Biol Chem
; 289(16): 10989-10998, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24519932
8.
Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.
J Biol Chem
; 289(43): 30177-88, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25213859
9.
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals.
Gastroenterology
; 145(2): 366-74.e1-3, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23597726
10.
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.
Mol Metab
; 80: 101874, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38211723
11.
Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione.
J Biol Chem
; 287(28): 23537-48, 2012 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22621923
12.
Cellular stress and coagulation factor production: when more is not necessarily better.
J Thromb Haemost
; 21(12): 3329-3341, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37839613
13.
Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.
J Lipid Res
; 53(5): 990-999, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22394502
14.
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Cell Metab
; 4(3): 199-210, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16950137
15.
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB).
J Biol Chem
; 285(34): 25996-6004, 2010 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20551328
16.
Chop/Ddit3 depletion in ß cells alleviates ER stress and corrects hepatic steatosis in mice.
Sci Transl Med
; 13(604)2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34321322
17.
Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice.
J Lipid Res
; 51(3): 554-63, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19749180
18.
1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.
Circulation
; 120(8): 687-98, 2009 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19667238
19.
Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.
Arterioscler Thromb Vasc Biol
; 28(10): 1738-44, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18669885
20.
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
Elife
; 82019 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31184304