RESUMO
AFM of cocrystals: Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules. The conversion of a metastable polymorph of the caffeine-glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent-contact-mode atomic force microscopy.
Assuntos
Cristalização , Microscopia de Força Atômica/métodos , Cafeína/química , Glutaratos/química , Transição de Fase , Propriedades de Superfície , TermodinâmicaRESUMO
Here, we highlight recent research involving atomic force microscopy investigations of molecular crystals, and focus particularly on the latest relevant advances in our knowledge of crystal-growth mechanisms and structure-property relationships in organic crystals. This brief survey features the importance of incorporating AFM into solid-state research as an essential tool for the informed design and construction of crystalline materials.
Assuntos
Engenharia/métodos , Microscopia de Força Atômica/métodos , Cristalização , Fenômenos Mecânicos , Nanotecnologia , Propriedades de Superfície , TemperaturaRESUMO
Liquid-assisted grinding allows the rapid, waste-free and one-pot synthesis of a variety of magnesium drug derivatives directly from the excipient MgO; such reactivity is relevant for the behaviour of ibuprofen formulations involving MgO and can be used for oxide-based mechanosynthesis of metal-organic salts, discrete complexes and carboxylate clusters involving magnesium and pharmaceutically active ingredients.