Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046436
2.
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Antimicrob Agents Chemother
; 66(4): e0210921, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266827
3.
Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.
J Immunol
; 200(3): 1110-1123, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29263214
4.
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.
Nat Chem Biol
; 13(5): 486-493, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28244987
5.
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat Chem Biol
; 13(6): 624-632, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346406
6.
TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.
Hepatology
; 66(4): 1197-1218, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28543567
7.
Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.
Circulation
; 131(7): 656-68, 2015 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25520375
8.
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery.
Chembiochem
; 17(7): 570-5, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26895508
9.
Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.
J Immunol
; 201(5): 1599, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30006376
10.
pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays.
Methods
; 65(2): 165-74, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886911
11.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
12.
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.
Bioorg Med Chem Lett
; 24(3): 1000-1004, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412070
13.
High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects.
Biochem Pharmacol
; 219: 115937, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37995979
14.
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Biochemistry
; 52(52): 9456-69, 2013 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-24274581
15.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Bioorg Med Chem Lett
; 22(21): 6656-60, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010269
16.
Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.
Biochemistry
; 50(25): 5633-47, 2011 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21534610
17.
Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
J Med Chem
; 64(9): 5645-5653, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33914534
18.
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and ß-arrestin2 with antinociceptive activity.
Mol Pharmacol
; 78(4): 560-8, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20826425
19.
Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening.
Molecules
; 15(5): 3010-37, 2010 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20657462
20.
Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells.
Clin Cancer Res
; 26(21): 5759-5771, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32669373