1.
Org Biomol Chem
; 16(14): 2393-2396, 2018 04 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29560484
RESUMO
A practical methodology for the synthesis of key intermediates for isoprostane, neuroprostane and dihomo-isoprostane preparation has been described. The key strategy involved a three stage C-12 stereocenter inversion of the configuration of a Corey lactone, commercially available in an enantiopure form. The key intermediate was then used to prepare 17-E2c-dihomo-isoprostane and 17-F2c-dihomo-isoprostane.