Detalhe da pesquisa
1.
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Bioorg Med Chem Lett
; 20(15): 4359-63, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615696
2.
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept.
Nat Rev Drug Discov
; 6(5): 357-72, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17464295
3.
TRP channels and pain.
Biochim Biophys Acta
; 1772(8): 978-88, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17467247
4.
Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist.
J Pharmacol Exp Ther
; 327(3): 898-909, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18753409
5.
Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.
J Pharmacol Exp Ther
; 327(3): 620-33, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18772321
6.
1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Bioorg Med Chem Lett
; 18(18): 5027-31, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752949
7.
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662872
8.
Transient receptor potential ion channels as targets for the discovery of pain therapeutics.
Curr Opin Investig Drugs
; 6(1): 48-57, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15675603
9.
Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse.
Brain Res
; 961(1): 147-52, 2003 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12535787
10.
Locomotor activity in a novel environment as a test of inflammatory pain in rats.
Methods Mol Biol
; 617: 67-78, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20336414
11.
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
J Med Chem
; 53(8): 3330-48, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20307063
12.
TRP channels and pain.
Curr Pharm Des
; 15(15): 1736-49, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19442187
13.
C5a, but not C3a, increases VEGF secretion in ARPE-19 human retinal pigment epithelial cells.
Curr Eye Res
; 34(1): 57-61, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19172471
14.
New frontiers in assessing pain and analgesia in laboratory animals.
Expert Opin Drug Discov
; 3(9): 1099-108, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23506182
15.
Inflammation-induced reduction of spontaneous activity by adjuvant: A novel model to study the effect of analgesics in rats.
J Pharmacol Exp Ther
; 320(1): 194-201, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17050782
16.
Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation.
Ann Thorac Surg
; 83(1): 146-52, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17184649
17.
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Bioorg Med Chem Lett
; 16(19): 5217-21, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870426
18.
Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion.
Proc Natl Acad Sci U S A
; 102(39): 14092-7, 2005 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16174730
19.
Biochemical pharmacology of the vanilloid receptor TRPV1. An update.
Eur J Biochem
; 271(10): 1814-9, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15128291
20.
Hunting for ion channel modulators with herpes simplex virus.
Nat Methods
; 4(9): 692-3, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17762875